MAP1LC3B — 24 ClinVar variants
All ClinVar germline MAP1LC3B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 21 flagged for review →
1 Benign · 2 Likely benign · 21 Uncertain significance
Full MAP1LC3B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 21
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 11
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MAP1LC3B p.Arg24Pro Uncertain significance Single submitter
- MAP1LC3B p.Asn74Ser Uncertain significance Single submitter
- MAP1LC3B p.Asp56Gly Uncertain significance Single submitter
- MAP1LC3B p.Gln77Arg Uncertain significance Single submitter
- MAP1LC3B p.Leu44Pro Uncertain significance Single submitter
- MAP1LC3B p.Met88Thr Uncertain significance Single submitter
- MAP1LC3B p.Phe79Leu Uncertain significance Single submitter
- MAP1LC3B p.Pro2Arg Uncertain significance Single submitter
- MAP1LC3B p.Pro55Leu Uncertain significance Single submitter
- MAP1LC3B p.Thr29Asn Uncertain significance Single submitter
- MAP1LC3B p.Thr50Arg Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- MAP1LC3B p.Asn84Lys Uncertain significance Single submitter
- MAP1LC3B p.Gln15Arg Uncertain significance Single submitter
- MAP1LC3B p.Glu102Lys Uncertain significance Single submitter
- MAP1LC3B p.His86Asp Uncertain significance Single submitter
- MAP1LC3B p.Leu44Phe Uncertain significance Single submitter
- MAP1LC3B p.Ser92Cys Uncertain significance Single submitter
- MAP1LC3B p.Thr29Ile Uncertain significance Single submitter
- MAP1LC3B p.Val112Ile Uncertain significance Single submitter
- MAP1LC3B p.Val91Ile Uncertain significance Single submitter
- MAP1LC3B p.Val98Leu Uncertain significance Single submitter
All MAP1LC3B variants
Benign 1
- p.Glu25Gln Single submitter
Uncertain significance 21
- p.Arg24Pro Single submitter ⚠
- p.Asn74Ser Single submitter ⚠
- p.Asn84Lys Single submitter ⚠
- p.Asp56Gly Single submitter ⚠
- p.Gln15Arg Single submitter ⚠
- p.Gln77Arg Single submitter ⚠
- p.Glu102Lys Single submitter ⚠
- p.His86Asp Single submitter ⚠
- p.Leu44Phe Single submitter ⚠
- p.Leu44Pro Single submitter ⚠
- p.Met88Thr Single submitter ⚠
- p.Phe79Leu Single submitter ⚠
- p.Pro2Arg Single submitter ⚠
- p.Pro55Leu Single submitter ⚠
- p.Ser92Cys Single submitter ⚠
- p.Thr29Asn Single submitter ⚠
- p.Thr29Ile Single submitter ⚠
- p.Thr50Arg Single submitter ⚠
- p.Val112Ile Single submitter ⚠
- p.Val91Ile Single submitter ⚠
- p.Val98Leu Single submitter ⚠