MAP1LC3C — 23 ClinVar variants
All ClinVar germline MAP1LC3C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 21 flagged for review →
1 Likely benign · 22 Uncertain significance
Full MAP1LC3C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 21
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MAP1LC3C p.Ala120Asp Uncertain significance Single submitter
- MAP1LC3C p.Glu24Lys Uncertain significance Single submitter
- MAP1LC3C p.Ile7Met Uncertain significance Single submitter
- MAP1LC3C p.Leu147Phe Uncertain significance Single submitter
- MAP1LC3C p.Leu70Pro Uncertain significance Single submitter
- MAP1LC3C p.Leu88Met Uncertain significance Single submitter
- MAP1LC3C p.Lys57Asn Uncertain significance Single submitter
- MAP1LC3C p.Lys57Glu Uncertain significance Single submitter
- MAP1LC3C p.Met101Thr Uncertain significance Single submitter
- MAP1LC3C p.Pro2Arg Uncertain significance Single submitter
- MAP1LC3C p.Pro34Arg Uncertain significance Single submitter
- MAP1LC3C p.Ser138Arg Uncertain significance Single submitter
- MAP1LC3C p.Thr65Asn Uncertain significance Single submitter
- MAP1LC3C p.Thr65Ser Uncertain significance Single submitter
- MAP1LC3C p.Tyr105Cys Uncertain significance Single submitter
- MAP1LC3C p.Val26Ala Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
- MAP1LC3C p.Ala120Thr Uncertain significance Single submitter
- MAP1LC3C p.Met97Ile Uncertain significance Single submitter
- MAP1LC3C p.Met97Lys Uncertain significance Single submitter
- MAP1LC3C p.Thr82Met Uncertain significance Single submitter
- MAP1LC3C p.Tyr105Asp Uncertain significance Single submitter
All MAP1LC3C variants
Likely benign 1
- p.Met97Thr Single submitter
Uncertain significance 22
- p.Ala120Asp Single submitter ⚠
- p.Ala120Thr Single submitter ⚠
- p.Glu24Lys Single submitter ⚠
- p.Ile73Met Single submitter
- p.Ile7Met Single submitter ⚠
- p.Leu147Phe Single submitter ⚠
- p.Leu70Pro Single submitter ⚠
- p.Leu88Met Single submitter ⚠
- p.Lys57Asn Single submitter ⚠
- p.Lys57Glu Single submitter ⚠
- p.Met101Thr Single submitter ⚠
- p.Met97Ile Single submitter ⚠
- p.Met97Lys Single submitter ⚠
- p.Pro2Arg Single submitter ⚠
- p.Pro34Arg Single submitter ⚠
- p.Ser138Arg Single submitter ⚠
- p.Thr65Asn Single submitter ⚠
- p.Thr65Ser Single submitter ⚠
- p.Thr82Met Single submitter ⚠
- p.Tyr105Asp Single submitter ⚠
- p.Tyr105Cys Single submitter ⚠
- p.Val26Ala Single submitter ⚠