MAP2K3 — 54 ClinVar variants
All ClinVar germline MAP2K3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 20 flagged for review →
1 Conflicting · 20 Benign · 15 Likely benign · 18 Uncertain significance
Full MAP2K3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 20
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
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MAP2K3 p.Arg96Trp
Conflicting
Single submitter
MAP2K3-related disorder
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
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MAP2K3 p.Leu215Trp
Uncertain significance
Multiple submitters
MAP2K3-related disorder
- MAP2K3 p.Ala10Thr Uncertain significance Single submitter
- MAP2K3 p.Ala303Val Uncertain significance Single submitter
- MAP2K3 p.Arg72Leu Uncertain significance Single submitter
- MAP2K3 p.Asn158Ser Uncertain significance Single submitter
- MAP2K3 p.Gln14His Uncertain significance Single submitter
- MAP2K3 p.Gln85His Uncertain significance Single submitter
- MAP2K3 p.Gln8Arg Uncertain significance Single submitter
- MAP2K3 p.Gly87Ser Uncertain significance Single submitter
- MAP2K3 p.Ile27Val Uncertain significance Single submitter
- MAP2K3 p.Met109Val Uncertain significance Single submitter
- MAP2K3 p.Met12Ile Uncertain significance Single submitter
- MAP2K3 p.Met258Thr Uncertain significance Single submitter
- MAP2K3 p.Ser212Arg Uncertain significance Single submitter
- MAP2K3 p.Ser7Arg Uncertain significance Single submitter
- MAP2K3 p.Thr333Met Uncertain significance Single submitter
- MAP2K3 p.Thr88Ile Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All MAP2K3 variants
Conflicting classifications of pathogenicity 1
- p.Arg96Trp Single submitter MAP2K3-related disorder ⚠
Benign 20
- c.568+10C>T Multiple submitters
- p.Ala220= Multiple submitters
- p.Leu25= Multiple submitters
- p.Pro40Thr Multiple submitters
- c.50-6T>C Single submitter
- c.774+9G>T Single submitter
- c.775-8C>T Single submitter
- p.Ala84Thr Single submitter
- p.Arg293His Single submitter
- p.Arg55Thr Single submitter
- p.Gly244Val Single submitter
- p.Ile52Thr Single submitter
- p.Leu166= Single submitter
- p.Met90Ile Single submitter
- p.Phe209= Single submitter
- p.Ser68Pro Single submitter
- p.Thr222Met Single submitter
- p.Thr273= Single submitter
- p.Thr326= Single submitter
- p.Val339Met Single submitter ⚠
Likely benign 15
- p.Ala225= Multiple submitters
- p.Leu319= Multiple submitters
- p.Ser286= Multiple submitters
- p.Thr39Ile Multiple submitters
- p.Ala291= Single submitter
- p.Arg72= Single submitter
- p.Asp135= Single submitter
- p.Asp208Val Single submitter
- p.Ile169Thr Single submitter
- p.Met223Ile Single submitter
- p.Ser249= Single submitter
- p.Ser86= Single submitter
- p.Tyr268= Single submitter
- p.Val251Ile Single submitter
- p.Val81= Single submitter
Uncertain significance 18
- p.Leu215Trp Multiple submitters MAP2K3-related disorder ⚠
- p.Ala10Thr Single submitter ⚠
- p.Ala303Val Single submitter ⚠
- p.Arg72Leu Single submitter ⚠
- p.Asn158Ser Single submitter ⚠
- p.Gln14His Single submitter ⚠
- p.Gln85His Single submitter ⚠
- p.Gln8Arg Single submitter ⚠
- p.Gly87Ser Single submitter ⚠
- p.Ile27Val Single submitter ⚠
- p.Met109Val Single submitter ⚠
- p.Met12Ile Single submitter ⚠
- p.Met258Thr Single submitter ⚠
- p.Ser212Arg Single submitter ⚠
- p.Ser7Arg Single submitter ⚠
- p.Thr333Met Single submitter ⚠
- p.Thr88Ile Single submitter ⚠
- p.Val174Leu Single submitter ⚠