MAP2K4 — 33 ClinVar variants
All ClinVar germline MAP2K4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
33 Uncertain significance
Full MAP2K4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MAP2K4 p.Ala33Val Uncertain significance Single submitter
- MAP2K4 p.Arg262Gly Uncertain significance Single submitter
- MAP2K4 p.Asn242Ser Uncertain significance Single submitter
-
MAP2K4 p.Gln316Leu
Uncertain significance
Single submitter
neurodevelopmental disorder
- MAP2K4 p.Gly15Ser Uncertain significance Single submitter
- MAP2K4 p.Gly9Ser Uncertain significance Single submitter
- MAP2K4 p.Ile200Val Uncertain significance Single submitter
- MAP2K4 p.Ile89Leu Uncertain significance Single submitter
- MAP2K4 p.Leu236Ile Uncertain significance Single submitter
- MAP2K4 p.Met119Ile Uncertain significance Single submitter
- MAP2K4 p.Pro23Thr Uncertain significance Single submitter
- MAP2K4 p.Pro27Gln Uncertain significance Single submitter
- MAP2K4 p.Pro63His Uncertain significance Single submitter
- MAP2K4 p.Pro6Ala Uncertain significance Single submitter
- MAP2K4 p.Ser18Arg Uncertain significance Single submitter
- MAP2K4 p.Ser35Ile Uncertain significance Single submitter
- MAP2K4 p.Ser5Ile Uncertain significance Single submitter
- MAP2K4 p.Thr20Ile Uncertain significance Single submitter
- MAP2K4 p.Val24Ala Uncertain significance Single submitter
- MAP2K4 p.Val24Ile Uncertain significance Single submitter
- MAP2K4 p.Val290Ile Uncertain significance Single submitter
- MAP2K4 p.Val381Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- MAP2K4 p.Asp157Glu Uncertain significance Single submitter
- MAP2K4 p.Gly11Arg Uncertain significance Single submitter
- MAP2K4 p.Gly9Arg Uncertain significance Single submitter
- MAP2K4 p.Gly9Asp Uncertain significance Single submitter
- MAP2K4 p.Gly9Cys Uncertain significance Single submitter
- MAP2K4 p.Pro338Leu Uncertain significance Single submitter
- MAP2K4 p.Tyr191Cys Uncertain significance Single submitter
All MAP2K4 variants
Uncertain significance 33
- c.116-2A>C Single submitter
- p.Ala33Val Single submitter ⚠
- p.Ala378Pro Single submitter
- p.Arg262Gly Single submitter ⚠
- p.Arg58Gly Single submitter
- p.Asn242Ser Single submitter ⚠
- p.Asp157Glu Single submitter ⚠
- p.Gln316Leu Single submitter neurodevelopmental disorder ⚠
- p.Gly11Arg Single submitter ⚠
- p.Gly15Ser Single submitter ⚠
- p.Gly9Arg Single submitter ⚠
- p.Gly9Asp Single submitter ⚠
- p.Gly9Cys Single submitter ⚠
- p.Gly9Ser Single submitter ⚠
- p.Ile200Val Single submitter ⚠
- p.Ile89Leu Single submitter ⚠
- p.Leu236Ile Single submitter ⚠
- p.Lys309fs Single submitter
- p.Met119Ile Single submitter ⚠
- p.Pro23Thr Single submitter ⚠
- p.Pro27Gln Single submitter ⚠
- p.Pro338Leu Single submitter ⚠
- p.Pro63His Single submitter ⚠
- p.Pro6Ala Single submitter ⚠
- p.Ser18Arg Single submitter ⚠
- p.Ser35Ile Single submitter ⚠
- p.Ser5Ile Single submitter ⚠
- p.Thr20Ile Single submitter ⚠
- p.Tyr191Cys Single submitter ⚠
- p.Val24Ala Single submitter ⚠
- p.Val24Ile Single submitter ⚠
- p.Val290Ile Single submitter ⚠
- p.Val381Ile Single submitter ⚠