MAP2K5 — 37 ClinVar variants
All ClinVar germline MAP2K5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 28 flagged for review →
3 Benign · 1 Likely benign · 33 Uncertain significance
Full MAP2K5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 28
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MAP2K5 p.Ala150Ser Uncertain significance Single submitter
- MAP2K5 p.Ala157Thr Uncertain significance Single submitter
- MAP2K5 p.Ala266Val Uncertain significance Single submitter
- MAP2K5 p.Ala437Ser Uncertain significance Single submitter
- MAP2K5 p.Arg125Gln Uncertain significance Single submitter
- MAP2K5 p.Arg169Gln Uncertain significance Single submitter
- MAP2K5 p.Arg236Lys Uncertain significance Single submitter
- MAP2K5 p.Arg253Ser Uncertain significance Single submitter
- MAP2K5 p.Arg436Gln Uncertain significance Single submitter
- MAP2K5 p.Arg442Gln Uncertain significance Single submitter
- MAP2K5 p.Asp66Glu Uncertain significance Single submitter
- MAP2K5 p.Asp75Val Uncertain significance Single submitter
- MAP2K5 p.Gln296Glu Uncertain significance Single submitter
- MAP2K5 p.Gln444Arg Uncertain significance Single submitter
- MAP2K5 p.Glu114Lys Uncertain significance Single submitter
- MAP2K5 p.Gly270Val Uncertain significance Single submitter
- MAP2K5 p.Gly7Val Uncertain significance Single submitter
- MAP2K5 p.Ile99Val Uncertain significance Single submitter
- MAP2K5 p.Met432Val Uncertain significance Single submitter
- MAP2K5 p.Pro448Leu Uncertain significance Single submitter
- MAP2K5 p.Ser87Phe Uncertain significance Single submitter
- MAP2K5 p.Tyr181Cys Uncertain significance Single submitter
- MAP2K5 p.Val233Ala Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All MAP2K5 variants
Benign 3
- c.586-8A>G Multiple submitters
- c.184+7C>T Single submitter
- p.Asp283= Single submitter
Likely benign 1
- p.Val420Met Single submitter
Uncertain significance 33
- c.1074+1G>A Single submitter
- p.Ala150Ser Single submitter ⚠
- p.Ala157Thr Single submitter ⚠
- p.Ala266Val Single submitter ⚠
- p.Ala437Ser Single submitter ⚠
- p.Arg125Gln Single submitter ⚠
- p.Arg125Trp Single submitter
- p.Arg169Gln Single submitter ⚠
- p.Arg236Lys Single submitter ⚠
- p.Arg253Ser Single submitter ⚠
- p.Arg436Gln Single submitter ⚠
- p.Arg436Leu Single submitter
- p.Arg436Trp Single submitter
- p.Arg442Gln Single submitter ⚠
- p.Asp66Glu Single submitter ⚠
- p.Asp75Val Single submitter ⚠
- p.Gln296Glu Single submitter ⚠
- p.Gln444Arg Single submitter ⚠
- p.Glu114Lys Single submitter ⚠
- p.Gly270Val Single submitter ⚠
- p.Gly364Arg Single submitter ⚠
- p.Gly7Val Single submitter ⚠
- p.Ile224Val Single submitter
- p.Ile99Val Single submitter ⚠
- p.Met347Thr Single submitter ⚠
- p.Met432Val Single submitter ⚠
- p.Phe346Ser Single submitter ⚠
- p.Pro417Leu Single submitter ⚠
- p.Pro448Leu Single submitter ⚠
- p.Ser87Phe Single submitter ⚠
- p.Tyr181Cys Single submitter ⚠
- p.Tyr252Cys Single submitter ⚠
- p.Val233Ala Single submitter ⚠