MAP2K6 — 17 ClinVar variants
All ClinVar germline MAP2K6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 17 flagged for review →
17 Uncertain significance
Full MAP2K6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 17
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MAP2K6 p.Ala189Asp Uncertain significance Single submitter
- MAP2K6 p.Arg254Gln Uncertain significance Single submitter
- MAP2K6 p.Glu167Ala Uncertain significance Single submitter
- MAP2K6 p.Ile144Val Uncertain significance Single submitter
- MAP2K6 p.Ile39Val Uncertain significance Single submitter
- MAP2K6 p.Ile56Val Uncertain significance Single submitter
- MAP2K6 p.Leu186Val Uncertain significance Single submitter
- MAP2K6 p.Leu190Ile Uncertain significance Single submitter
- MAP2K6 p.Lys300Arg Uncertain significance Single submitter
- MAP2K6 p.Lys329Thr Uncertain significance Single submitter
- MAP2K6 p.Lys49Glu Uncertain significance Single submitter
- MAP2K6 p.Thr28Ala Uncertain significance Single submitter
- MAP2K6 p.Val67Ala Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All MAP2K6 variants
Uncertain significance 17
- p.Ala189Asp Single submitter ⚠
- p.Arg254Gln Single submitter ⚠
- p.Glu167Ala Single submitter ⚠
- p.Gly147Val Single submitter ⚠
- p.Ile144Val Single submitter ⚠
- p.Ile39Val Single submitter ⚠
- p.Ile56Val Single submitter ⚠
- p.Leu186Val Single submitter ⚠
- p.Leu190Ile Single submitter ⚠
- p.Lys300Arg Single submitter ⚠
- p.Lys329Thr Single submitter ⚠
- p.Lys49Glu Single submitter ⚠
- p.Pro274Ser Single submitter ⚠
- p.Ser275Leu Single submitter ⚠
- p.Ser326Phe Single submitter ⚠
- p.Thr28Ala Single submitter ⚠
- p.Val67Ala Single submitter ⚠