MAP2K7 — 52 ClinVar variants
All ClinVar germline MAP2K7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
9 Benign · 4 Likely benign · 39 Uncertain significance
Full MAP2K7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MAP2K7 p.Arg217His Uncertain significance Single submitter
- MAP2K7 p.Arg254Gln Uncertain significance Single submitter
- MAP2K7 p.Arg405Gln Uncertain significance Single submitter
- MAP2K7 p.Asn189Ser Uncertain significance Single submitter
- MAP2K7 p.Gln19Glu Uncertain significance Single submitter
- MAP2K7 p.Gly279Ser Uncertain significance Single submitter
- MAP2K7 p.Gly345Arg Uncertain significance Single submitter
- MAP2K7 p.Gly351Arg Uncertain significance Single submitter
- MAP2K7 p.Gly52Val Uncertain significance Single submitter
- MAP2K7 p.Gly76Glu Uncertain significance Single submitter
- MAP2K7 p.Ile108Val Uncertain significance Single submitter
- MAP2K7 p.Ile34Met Uncertain significance Single submitter
- MAP2K7 p.Leu123Met Uncertain significance Single submitter
- MAP2K7 p.Lys367Asn Uncertain significance Single submitter
- MAP2K7 p.Pro413Leu Uncertain significance Single submitter
- MAP2K7 p.Pro67Leu Uncertain significance Single submitter
- MAP2K7 p.Pro84Leu Uncertain significance Single submitter
- MAP2K7 p.Ser411Ile Uncertain significance Single submitter
- MAP2K7 p.Ser55Leu Uncertain significance Single submitter
- MAP2K7 p.Ser57Pro Uncertain significance Single submitter
- MAP2K7 p.Ser86Asn Uncertain significance Single submitter
- MAP2K7 p.Thr401Ile Uncertain significance Single submitter
- MAP2K7 p.Val239Gly Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- MAP2K7 p.Ala399Val Uncertain significance Single submitter
- MAP2K7 p.Arg209Gln Uncertain significance Single submitter
- MAP2K7 p.Arg217Cys Uncertain significance Single submitter
- MAP2K7 p.Arg254Trp Uncertain significance Single submitter
- MAP2K7 p.Asn372Asp Uncertain significance Single submitter
- MAP2K7 p.Gly143Ser Uncertain significance Single submitter
- MAP2K7 p.Ile310Val Uncertain significance Single submitter
- MAP2K7 p.Lys141Glu Uncertain significance Single submitter
- MAP2K7 p.Lys395Glu Uncertain significance Single submitter
- MAP2K7 p.Pro404Gln Uncertain significance Single submitter
- MAP2K7 p.Thr185Met Uncertain significance Single submitter
- MAP2K7 p.Val148Ile Uncertain significance Single submitter
All MAP2K7 variants
Benign 9
- c.855+10G>C Multiple submitters
- c.856-19T>C Multiple submitters
- c.856-8C>G Multiple submitters
- p.Cys131= Multiple submitters
- p.Pro215= Multiple submitters
- p.Ser277= Multiple submitters
- c.1079+9C>T Single submitter
- p.Cys202= Single submitter
- p.Ser265= Single submitter
Likely benign 4
- c.1080-4C>G Single submitter
- c.856-9C>G Single submitter
- p.Asp243= Single submitter
- p.Pro404= Single submitter
Uncertain significance 39
- p.Ala391Val Single submitter
- p.Ala399Val Single submitter ⚠
- p.Arg12Leu Single submitter
- p.Arg140Trp Single submitter
- p.Arg209Gln Single submitter ⚠
- p.Arg217Cys Single submitter ⚠
- p.Arg217His Single submitter ⚠
- p.Arg254Gln Single submitter ⚠
- p.Arg254Trp Single submitter ⚠
- p.Arg405Gln Single submitter ⚠
- p.Arg85Cys Single submitter
- p.Asn189Ser Single submitter ⚠
- p.Asn372Asp Single submitter ⚠
- p.Gln19Glu Single submitter ⚠
- p.Gly143Ser Single submitter ⚠
- p.Gly279Ser Single submitter ⚠
- p.Gly345Arg Single submitter ⚠
- p.Gly351Arg Single submitter ⚠
- p.Gly52Val Single submitter ⚠
- p.Gly76Glu Single submitter ⚠
- p.Ile108Val Single submitter ⚠
- p.Ile310Val Single submitter ⚠
- p.Ile34Met Single submitter ⚠
- p.Leu123Met Single submitter ⚠
- p.Lys141Glu Single submitter ⚠
- p.Lys367Asn Single submitter ⚠
- p.Lys395Glu Single submitter ⚠
- p.Pro404Gln Single submitter ⚠
- p.Pro413Leu Single submitter ⚠
- p.Pro67Leu Single submitter ⚠
- p.Pro84Leu Single submitter ⚠
- p.Ser411Ile Single submitter ⚠
- p.Ser55Leu Single submitter ⚠
- p.Ser57Pro Single submitter ⚠
- p.Ser86Asn Single submitter ⚠
- p.Thr185Met Single submitter ⚠
- p.Thr401Ile Single submitter ⚠
- p.Val148Ile Single submitter ⚠
- p.Val239Gly Single submitter ⚠