MAP3K11 — 118 ClinVar variants
All ClinVar germline MAP3K11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 108 flagged for review →
1 Likely pathogenic · 4 Likely benign · 113 Uncertain significance
Full MAP3K11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 108
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 87
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MAP3K11 p.Ala169Thr Uncertain significance Single submitter
- MAP3K11 p.Ala282Pro Uncertain significance Single submitter
- MAP3K11 p.Ala287Thr Uncertain significance Single submitter
- MAP3K11 p.Ala352Ser Uncertain significance Single submitter
- MAP3K11 p.Ala370Val Uncertain significance Single submitter
- MAP3K11 p.Ala378Thr Uncertain significance Single submitter
- MAP3K11 p.Ala39Gly Uncertain significance Single submitter
- MAP3K11 p.Ala42Ser Uncertain significance Single submitter
- MAP3K11 p.Ala485Thr Uncertain significance Single submitter
- MAP3K11 p.Ala485Val Uncertain significance Single submitter
- MAP3K11 p.Ala653Thr Uncertain significance Single submitter
- MAP3K11 p.Ala76Thr Uncertain significance Single submitter
- MAP3K11 p.Arg209His Uncertain significance Single submitter
- MAP3K11 p.Arg365His Uncertain significance Single submitter
- MAP3K11 p.Arg484Gly Uncertain significance Single submitter
- MAP3K11 p.Arg513Lys Uncertain significance Single submitter
- MAP3K11 p.Arg546His Uncertain significance Single submitter
- MAP3K11 p.Arg551Gly Uncertain significance Single submitter
- MAP3K11 p.Arg561Gln Uncertain significance Single submitter
- MAP3K11 p.Arg615Gln Uncertain significance Single submitter
- MAP3K11 p.Arg615Trp Uncertain significance Single submitter
- MAP3K11 p.Arg669Pro Uncertain significance Single submitter
- MAP3K11 p.Arg671His Uncertain significance Single submitter
- MAP3K11 p.Arg729Gln Uncertain significance Single submitter
- MAP3K11 p.Arg735Cys Uncertain significance Single submitter
- MAP3K11 p.Arg73Gln Uncertain significance Single submitter
- MAP3K11 p.Arg747Cys Uncertain significance Single submitter
- MAP3K11 p.Asp153Asn Uncertain significance Single submitter
- MAP3K11 p.Asp357Ala Uncertain significance Single submitter
- MAP3K11 p.Asp465Asn Uncertain significance Single submitter
- MAP3K11 p.Asp593Glu Uncertain significance Single submitter
- MAP3K11 p.Asp660Asn Uncertain significance Single submitter
- MAP3K11 p.Asp704Gly Uncertain significance Single submitter
- MAP3K11 p.Asp808Ala Uncertain significance Single submitter
- MAP3K11 p.Cys697Ser Uncertain significance Single submitter
- MAP3K11 p.Gln91Glu Uncertain significance Single submitter
- MAP3K11 p.Glu319Asp Uncertain significance Single submitter
- MAP3K11 p.Glu377Asp Uncertain significance Single submitter
- MAP3K11 p.Glu380Lys Uncertain significance Single submitter
- MAP3K11 p.Glu414Gly Uncertain significance Single submitter
- MAP3K11 p.Glu53Lys Uncertain significance Single submitter
- MAP3K11 p.Gly14Arg Uncertain significance Single submitter
- MAP3K11 p.Gly23Ser Uncertain significance Single submitter
- MAP3K11 p.Gly488Ser Uncertain significance Single submitter
- MAP3K11 p.Gly632Asp Uncertain significance Single submitter
- MAP3K11 p.Gly668Val Uncertain significance Single submitter
- MAP3K11 p.Gly824Cys Uncertain significance Single submitter
- MAP3K11 p.His227Arg Uncertain significance Single submitter
- MAP3K11 p.Ile325Thr Uncertain significance Single submitter
- MAP3K11 p.Ile403Thr Uncertain significance Single submitter
- MAP3K11 p.Ile696Val Uncertain significance Single submitter
- MAP3K11 p.Leu189Pro Uncertain significance Single submitter
- MAP3K11 p.Leu496Val Uncertain significance Single submitter
- MAP3K11 p.Leu592Pro Uncertain significance Single submitter
- MAP3K11 p.Leu695Phe Uncertain significance Single submitter
- MAP3K11 p.Leu712Pro Uncertain significance Single submitter
- MAP3K11 p.Lys833Gln Uncertain significance Single submitter
- MAP3K11 p.Met355Ile Uncertain significance Single submitter
- MAP3K11 p.Pro106Ala Uncertain significance Single submitter
- MAP3K11 p.Pro150Leu Uncertain significance Single submitter
- MAP3K11 p.Pro32Ser Uncertain significance Single submitter
- MAP3K11 p.Pro549Ala Uncertain significance Single submitter
- MAP3K11 p.Pro549Ser Uncertain significance Single submitter
- MAP3K11 p.Pro599Leu Uncertain significance Single submitter
- MAP3K11 p.Pro607Ala Uncertain significance Single submitter
- MAP3K11 p.Pro607Leu Uncertain significance Single submitter
- MAP3K11 p.Pro614Ser Uncertain significance Single submitter
- MAP3K11 p.Pro663Leu Uncertain significance Single submitter
- MAP3K11 p.Pro664Leu Uncertain significance Single submitter
- MAP3K11 p.Pro675Leu Uncertain significance Single submitter
- MAP3K11 p.Pro681Ser Uncertain significance Single submitter
- MAP3K11 p.Pro685Ser Uncertain significance Single submitter
- MAP3K11 p.Pro687Leu Uncertain significance Single submitter
- MAP3K11 p.Pro743Thr Uncertain significance Single submitter
- MAP3K11 p.Pro760Ser Uncertain significance Single submitter
- MAP3K11 p.Pro794Ser Uncertain significance Single submitter
- MAP3K11 p.Ser160Asn Uncertain significance Single submitter
- MAP3K11 p.Ser371Cys Uncertain significance Single submitter
- MAP3K11 p.Ser570Phe Uncertain significance Single submitter
- MAP3K11 p.Ser598Phe Uncertain significance Single submitter
- MAP3K11 p.Ser617Arg Uncertain significance Single submitter
- MAP3K11 p.Ser746Leu Uncertain significance Single submitter
- MAP3K11 p.Ser770Leu Uncertain significance Single submitter
- MAP3K11 p.Thr262Ile Uncertain significance Single submitter
- MAP3K11 p.Val122Met Uncertain significance Single submitter
- MAP3K11 p.Val210Met Uncertain significance Single submitter
- MAP3K11 p.Val237Ile Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- MAP3K11 p.Ala76Val Uncertain significance Single submitter
- MAP3K11 p.Arg209Pro Uncertain significance Single submitter
- MAP3K11 p.Arg224Cys Uncertain significance Single submitter
- MAP3K11 p.Arg775Leu Uncertain significance Single submitter
- MAP3K11 p.Asn175His Uncertain significance Single submitter
- MAP3K11 p.Glu110Gly Uncertain significance Single submitter
- MAP3K11 p.Glu139Lys Uncertain significance Single submitter
- MAP3K11 p.Glu232Lys Uncertain significance Single submitter
- MAP3K11 p.Gly22Arg Uncertain significance Single submitter
- MAP3K11 p.Gly324Asp Uncertain significance Single submitter
- MAP3K11 p.Gly56Glu Uncertain significance Single submitter
- MAP3K11 p.Lys482Asn Uncertain significance Single submitter
- MAP3K11 p.Phe478Leu Uncertain significance Single submitter
- MAP3K11 p.Pro3Leu Uncertain significance Single submitter
- MAP3K11 p.Ser598Cys Uncertain significance Single submitter
- MAP3K11 p.Ser748Phe Uncertain significance Single submitter
- MAP3K11 p.Ser97Tyr Uncertain significance Single submitter
- MAP3K11 p.Thr298Ile Uncertain significance Single submitter
- MAP3K11 p.Thr682Met Likely benign Single submitter
- MAP3K11 p.Thr752Ile Uncertain significance Single submitter
- MAP3K11 p.Val471Met Uncertain significance Single submitter
All MAP3K11 variants
Likely pathogenic 1
- p.Ala283Thr No assertion criteria Moyamoya angiopathy
Likely benign 4
- p.Arg31Trp Single submitter
- p.Pro44= Single submitter
- p.Pro840= Single submitter
- p.Thr682Met Single submitter ⚠
Uncertain significance 113
- p.Ala169Thr Single submitter ⚠
- p.Ala282Pro Single submitter ⚠
- p.Ala287Thr Single submitter ⚠
- p.Ala352Ser Single submitter ⚠
- p.Ala370Val Single submitter ⚠
- p.Ala378Thr Single submitter ⚠
- p.Ala39Gly Single submitter ⚠
- p.Ala42Ser Single submitter ⚠
- p.Ala485Thr Single submitter ⚠
- p.Ala485Val Single submitter ⚠
- p.Ala653Thr Single submitter ⚠
- p.Ala76Thr Single submitter ⚠
- p.Ala76Val Single submitter ⚠
- p.Arg209His Single submitter ⚠
- p.Arg209Pro Single submitter ⚠
- p.Arg224Cys Single submitter ⚠
- p.Arg365His Single submitter ⚠
- p.Arg484Gly Single submitter ⚠
- p.Arg513Lys Single submitter ⚠
- p.Arg546His Single submitter ⚠
- p.Arg551Gly Single submitter ⚠
- p.Arg561Gln Single submitter ⚠
- p.Arg615Gln Single submitter ⚠
- p.Arg615Trp Single submitter ⚠
- p.Arg669Pro Single submitter ⚠
- p.Arg671His Single submitter ⚠
- p.Arg729Gln Single submitter ⚠
- p.Arg735Cys Single submitter ⚠
- p.Arg73Gln Single submitter ⚠
- p.Arg747Cys Single submitter ⚠
- p.Arg768Gln Single submitter
- p.Arg775Leu Single submitter ⚠
- p.Asn175His Single submitter ⚠
- p.Asp153Asn Single submitter ⚠
- p.Asp357Ala Single submitter ⚠
- p.Asp465Asn Single submitter ⚠
- p.Asp593Glu Single submitter ⚠
- p.Asp660Asn Single submitter ⚠
- p.Asp660Val Single submitter
- p.Asp704Gly Single submitter ⚠
- p.Asp808Ala Single submitter ⚠
- p.Cys697Ser Single submitter ⚠
- p.Gln251Lys Single submitter
- p.Gln374Pro Single submitter
- p.Gln91Glu Single submitter ⚠
- p.Glu110Gly Single submitter ⚠
- p.Glu139Lys Single submitter ⚠
- p.Glu232Lys Single submitter ⚠
- p.Glu319Asp Single submitter ⚠
- p.Glu377Asp Single submitter ⚠
- p.Glu380Lys Single submitter ⚠
- p.Glu414Gly Single submitter ⚠
- p.Glu53Lys Single submitter ⚠
- p.Gly14Arg Single submitter ⚠
- p.Gly22Arg Single submitter ⚠
- p.Gly23Ser Single submitter ⚠
- p.Gly324Asp Single submitter ⚠
- p.Gly488Ser Single submitter ⚠
- p.Gly489Arg Single submitter
- p.Gly56Glu Single submitter ⚠
- p.Gly632Asp Single submitter ⚠
- p.Gly668Val Single submitter ⚠
- p.Gly824Cys Single submitter ⚠
- p.His227Arg Single submitter ⚠
- p.Ile325Thr Single submitter ⚠
- p.Ile403Thr Single submitter ⚠
- p.Ile696Val Single submitter ⚠
- p.Leu184Val Single submitter
- p.Leu189Pro Single submitter ⚠
- p.Leu496Val Single submitter ⚠
- p.Leu592Pro Single submitter ⚠
- p.Leu695Phe Single submitter ⚠
- p.Leu712Pro Single submitter ⚠
- p.Lys482Asn Single submitter ⚠
- p.Lys833Gln Single submitter ⚠
- p.Met355Ile Single submitter ⚠
- p.Phe478Leu Single submitter ⚠
- p.Pro106Ala Single submitter ⚠
- p.Pro150Leu Single submitter ⚠
- p.Pro32Ser Single submitter ⚠
- p.Pro3Leu Single submitter ⚠
- p.Pro549Ala Single submitter ⚠
- p.Pro549Ser Single submitter ⚠
- p.Pro599Leu Single submitter ⚠
- p.Pro607Ala Single submitter ⚠
- p.Pro607Leu Single submitter ⚠
- p.Pro614Ser Single submitter ⚠
- p.Pro663Leu Single submitter ⚠
- p.Pro664Leu Single submitter ⚠
- p.Pro675Leu Single submitter ⚠
- p.Pro681Ser Single submitter ⚠
- p.Pro685Ser Single submitter ⚠
- p.Pro687Leu Single submitter ⚠
- p.Pro743Thr Single submitter ⚠
- p.Pro760Ser Single submitter ⚠
- p.Pro794Ser Single submitter ⚠
- p.Ser160Asn Single submitter ⚠
- p.Ser371Cys Single submitter ⚠
- p.Ser570Phe Single submitter ⚠
- p.Ser598Cys Single submitter ⚠
- p.Ser598Phe Single submitter ⚠
- p.Ser617Arg Single submitter ⚠
- p.Ser746Leu Single submitter ⚠
- p.Ser748Phe Single submitter ⚠
- p.Ser770Leu Single submitter ⚠
- p.Ser97Tyr Single submitter ⚠
- p.Thr262Ile Single submitter ⚠
- p.Thr298Ile Single submitter ⚠
- p.Thr752Ile Single submitter ⚠
- p.Val122Met Single submitter ⚠
- p.Val210Met Single submitter ⚠
- p.Val237Ile Single submitter ⚠
- p.Val471Met Single submitter ⚠