MAP3K12 — 68 ClinVar variants
All ClinVar germline MAP3K12 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 56 flagged for review →
1 Benign · 67 Uncertain significance
Full MAP3K12 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 56
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 49
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MAP3K12 p.Gly661Arg Uncertain significance Multiple submitters
- MAP3K12 p.Ala671Asp Uncertain significance Single submitter
- MAP3K12 p.Arg106Gln Uncertain significance Single submitter
- MAP3K12 p.Arg176Cys Uncertain significance Single submitter
- MAP3K12 p.Arg236Trp Uncertain significance Single submitter
- MAP3K12 p.Arg488Lys Uncertain significance Single submitter
- MAP3K12 p.Arg572Gln Uncertain significance Single submitter
- MAP3K12 p.Arg574His Uncertain significance Single submitter
- MAP3K12 p.Arg654Trp Uncertain significance Single submitter
- MAP3K12 p.Arg656Gln Uncertain significance Single submitter
- MAP3K12 p.Arg721Gln Uncertain significance Single submitter
- MAP3K12 p.Arg721Trp Uncertain significance Single submitter
- MAP3K12 p.Arg725Gln Uncertain significance Single submitter
- MAP3K12 p.Arg748Cys Uncertain significance Single submitter
- MAP3K12 p.Arg778His Uncertain significance Single submitter
- MAP3K12 p.Arg8Gln Uncertain significance Single submitter
- MAP3K12 p.Cys563Tyr Uncertain significance Single submitter
- MAP3K12 p.Gln773His Uncertain significance Single submitter
- MAP3K12 p.Glu621Asp Uncertain significance Single submitter
- MAP3K12 p.Glu855Ala Uncertain significance Single submitter
- MAP3K12 p.Gly614Arg Uncertain significance Single submitter
- MAP3K12 p.Gly615Arg Uncertain significance Single submitter
- MAP3K12 p.Gly663Arg Uncertain significance Single submitter
- MAP3K12 p.Gly714Arg Uncertain significance Single submitter
- MAP3K12 p.Gly804Val Uncertain significance Single submitter
- MAP3K12 p.Gly828Ser Uncertain significance Single submitter
- MAP3K12 p.His632Asp Uncertain significance Single submitter
- MAP3K12 p.Leu29Val Uncertain significance Single submitter
- MAP3K12 p.Leu646Met Uncertain significance Single submitter
- MAP3K12 p.Leu781Arg Uncertain significance Single submitter
- MAP3K12 p.Lys525Arg Uncertain significance Single submitter
- MAP3K12 p.Lys550Asn Uncertain significance Single submitter
- MAP3K12 p.Lys577Arg Uncertain significance Single submitter
- MAP3K12 p.Pro388Leu Uncertain significance Single submitter
- MAP3K12 p.Pro529Thr Uncertain significance Single submitter
- MAP3K12 p.Pro567Thr Uncertain significance Single submitter
- MAP3K12 p.Pro91Leu Uncertain significance Single submitter
- MAP3K12 p.Pro98Ser Uncertain significance Single submitter
- MAP3K12 p.Ser359Gly Uncertain significance Single submitter
- MAP3K12 p.Ser573Asn Uncertain significance Single submitter
- MAP3K12 p.Ser724Ile Uncertain significance Single submitter
- MAP3K12 p.Ser728Cys Uncertain significance Single submitter
- MAP3K12 p.Ser728Phe Uncertain significance Single submitter
- MAP3K12 p.Ser768Ile Uncertain significance Single submitter
- MAP3K12 p.Ser798Asn Uncertain significance Single submitter
- MAP3K12 p.Ser878Pro Uncertain significance Single submitter
- MAP3K12 p.Thr141Ala Uncertain significance Single submitter
- MAP3K12 p.Thr675Asn Uncertain significance Single submitter
- MAP3K12 p.Val364Met Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- MAP3K12 p.Asp194Asn Uncertain significance Single submitter
- MAP3K12 p.Ile541Thr Uncertain significance Single submitter
- MAP3K12 p.Ile831Thr Uncertain significance Single submitter
- MAP3K12 p.Leu395Val Uncertain significance Single submitter
-
MAP3K12 p.Ser367Gly
Uncertain significance
Single submitter
Delayed speech and language development
- MAP3K12 p.Ser536Arg Uncertain significance Single submitter
- MAP3K12 p.Val759Ala Uncertain significance Single submitter
All MAP3K12 variants
Benign 1
- p.Gly673Ser Multiple submitters
Uncertain significance 67
- p.Gly661Arg Multiple submitters ⚠
- p.Ala671Asp Single submitter ⚠
- p.Arg106Gln Single submitter ⚠
- p.Arg176Cys Single submitter ⚠
- p.Arg236Trp Single submitter ⚠
- p.Arg488Lys Single submitter ⚠
- p.Arg572Gln Single submitter ⚠
- p.Arg574His Single submitter ⚠
- p.Arg637Cys Single submitter
- p.Arg654Trp Single submitter ⚠
- p.Arg656Gln Single submitter ⚠
- p.Arg721Gln Single submitter ⚠
- p.Arg721Trp Single submitter ⚠
- p.Arg725Gln Single submitter ⚠
- p.Arg748Cys Single submitter ⚠
- p.Arg778His Single submitter ⚠
- p.Arg8Gln Single submitter ⚠
- p.Asn471His Single submitter
- p.Asn527fs Single submitter
- p.Asp194Asn Single submitter ⚠
- p.Cys3Ser Single submitter
- p.Cys563Tyr Single submitter ⚠
- p.Gln773His Single submitter ⚠
- p.Glu621Asp Single submitter ⚠
- p.Glu855Ala Single submitter ⚠
- p.Gly614Arg Single submitter ⚠
- p.Gly615Arg Single submitter ⚠
- p.Gly663Arg Single submitter ⚠
- p.Gly714Arg Single submitter ⚠
- p.Gly804Val Single submitter ⚠
- p.Gly828Ser Single submitter ⚠
- p.His632Asp Single submitter ⚠
- p.Ile541Thr Single submitter ⚠
- p.Ile831Thr Single submitter ⚠
- p.Leu29Val Single submitter ⚠
- p.Leu395Val Single submitter ⚠
- p.Leu646Met Single submitter ⚠
- p.Leu781Arg Single submitter ⚠
- p.Lys525Arg Single submitter ⚠
- p.Lys550Asn Single submitter ⚠
- p.Lys577Arg Single submitter ⚠
- p.Pro130fs Single submitter
- p.Pro312fs Single submitter
- p.Pro388Leu Single submitter ⚠
- p.Pro529Thr Single submitter ⚠
- p.Pro54Leu Single submitter
- p.Pro567Thr Single submitter ⚠
- p.Pro73Thr Single submitter
- p.Pro850fs Single submitter
- p.Pro91Leu Single submitter ⚠
- p.Pro98Ser Single submitter ⚠
- p.Ser359Gly Single submitter ⚠
- p.Ser367Gly Single submitter Delayed speech and language development ⚠
- p.Ser536Arg Single submitter ⚠
- p.Ser573Asn Single submitter ⚠
- p.Ser642Pro Single submitter
- p.Ser724Ile Single submitter ⚠
- p.Ser728Cys Single submitter ⚠
- p.Ser728Phe Single submitter ⚠
- p.Ser768Ile Single submitter ⚠
- p.Ser798Asn Single submitter ⚠
- p.Ser878Pro Single submitter ⚠
- p.Thr141Ala Single submitter ⚠
- p.Thr675Asn Single submitter ⚠
- p.Val346Ile Single submitter
- p.Val364Met Single submitter ⚠
- p.Val759Ala Single submitter ⚠