MAP3K13 — 78 ClinVar variants
All ClinVar germline MAP3K13 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 65 flagged for review →
1 Benign · 4 Likely benign · 73 Uncertain significance
Full MAP3K13 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 65
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 58
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MAP3K13 p.Ala416Thr Uncertain significance Single submitter
- MAP3K13 p.Ala465Thr Uncertain significance Single submitter
- MAP3K13 p.Ala96Val Uncertain significance Single submitter
- MAP3K13 p.Arg278His Uncertain significance Single submitter
- MAP3K13 p.Arg326Trp Uncertain significance Single submitter
- MAP3K13 p.Arg401Gln Uncertain significance Single submitter
- MAP3K13 p.Arg478Gln Uncertain significance Single submitter
- MAP3K13 p.Arg503Cys Uncertain significance Single submitter
- MAP3K13 p.Arg517Gln Uncertain significance Single submitter
- MAP3K13 p.Arg517Gly Uncertain significance Single submitter
- MAP3K13 p.Arg521His Uncertain significance Single submitter
- MAP3K13 p.Arg53Gly Uncertain significance Single submitter
- MAP3K13 p.Arg548Trp Uncertain significance Single submitter
- MAP3K13 p.Asp78Glu Uncertain significance Single submitter
- MAP3K13 p.Asp947His Uncertain significance Single submitter
- MAP3K13 p.Asp947Val Uncertain significance Single submitter
- MAP3K13 p.Gln5Glu Uncertain significance Single submitter
- MAP3K13 p.Glu20Lys Uncertain significance Single submitter
- MAP3K13 p.Glu428Ala Uncertain significance Single submitter
- MAP3K13 p.Glu58Asp Uncertain significance Single submitter
- MAP3K13 p.Glu58Lys Uncertain significance Single submitter
- MAP3K13 p.Gly107Glu Uncertain significance Single submitter
- MAP3K13 p.Gly128Ser Uncertain significance Single submitter
- MAP3K13 p.Gly571Ala Uncertain significance Single submitter
- MAP3K13 p.Gly948Ala Uncertain significance Single submitter
- MAP3K13 p.Gly948Arg Uncertain significance Single submitter
- MAP3K13 p.His15Arg Uncertain significance Single submitter
- MAP3K13 p.His406Arg Uncertain significance Single submitter
- MAP3K13 p.His471Asn Uncertain significance Single submitter
- MAP3K13 p.Ile144Thr Uncertain significance Single submitter
- MAP3K13 p.Ile145Thr Uncertain significance Single submitter
- MAP3K13 p.Ile524Val Uncertain significance Single submitter
- MAP3K13 p.Ile57Met Uncertain significance Single submitter
- MAP3K13 p.Leu171Met Uncertain significance Single submitter
- MAP3K13 p.Leu171Pro Uncertain significance Single submitter
- MAP3K13 p.Leu43Phe Uncertain significance Single submitter
- MAP3K13 p.Leu486Ser Uncertain significance Single submitter
- MAP3K13 p.Met34Ile Uncertain significance Single submitter
- MAP3K13 p.Met34Thr Uncertain significance Single submitter
- MAP3K13 p.Met34Val Uncertain significance Single submitter
- MAP3K13 p.Met936Leu Uncertain significance Single submitter
- MAP3K13 p.Phe18Val Uncertain significance Single submitter
- MAP3K13 p.Pro519Ala Uncertain significance Single submitter
- MAP3K13 p.Ser815Cys Uncertain significance Single submitter
- MAP3K13 p.Ser941Leu Uncertain significance Single submitter
- MAP3K13 p.Ser941Pro Uncertain significance Single submitter
- MAP3K13 p.Thr104Met Uncertain significance Single submitter
- MAP3K13 p.Thr203Met Uncertain significance Single submitter
- MAP3K13 p.Thr224Ile Uncertain significance Single submitter
- MAP3K13 p.Thr261Ala Uncertain significance Single submitter
- MAP3K13 p.Thr546Asn Uncertain significance Single submitter
- MAP3K13 p.Thr957Ile Uncertain significance Single submitter
- MAP3K13 p.Tyr235Asn Uncertain significance Single submitter
- MAP3K13 p.Val197Leu Uncertain significance Single submitter
- MAP3K13 p.Val285Ile Uncertain significance Single submitter
- MAP3K13 p.Val520Leu Uncertain significance Single submitter
- MAP3K13 p.Val84Ile Uncertain significance Single submitter
- MAP3K13 p.Val97Leu Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- MAP3K13 p.Arg474Gln Uncertain significance Single submitter
- MAP3K13 p.Asn82Ile Uncertain significance Single submitter
- MAP3K13 p.Asp355Glu Uncertain significance Single submitter
- MAP3K13 p.Leu85Pro Uncertain significance Single submitter
- MAP3K13 p.Lys531Asn Uncertain significance Single submitter
- MAP3K13 p.Phe437Tyr Uncertain significance Single submitter
- MAP3K13 p.Ser425Phe Uncertain significance Single submitter
All MAP3K13 variants
Benign 1
- p.Ala465= Single submitter
Likely benign 4
- p.Arg139= Single submitter
- p.Arg53Gln Single submitter
- p.Glu44Lys Single submitter
- p.Pro526Ser Single submitter
Uncertain significance 73
- p.Ala416Thr Single submitter ⚠
- p.Ala465Thr Single submitter ⚠
- p.Ala96Val Single submitter ⚠
- p.Arg278His Single submitter ⚠
- p.Arg326Trp Single submitter ⚠
- p.Arg401Gln Single submitter ⚠
- p.Arg449Gln Single submitter
- p.Arg474Gln Single submitter ⚠
- p.Arg478Gln Single submitter ⚠
- p.Arg503Cys Single submitter ⚠
- p.Arg517Gln Single submitter ⚠
- p.Arg517Gly Single submitter ⚠
- p.Arg521His Single submitter ⚠
- p.Arg53Gly Single submitter ⚠
- p.Arg548Trp Single submitter ⚠
- p.Asn82Ile Single submitter ⚠
- p.Asp115Val Single submitter
- p.Asp355Glu Single submitter ⚠
- p.Asp78Glu Single submitter ⚠
- p.Asp947His Single submitter ⚠
- p.Asp947Val Single submitter ⚠
- p.Gln5Glu Single submitter ⚠
- p.Glu20Lys Single submitter ⚠
- p.Glu428Ala Single submitter ⚠
- p.Glu477Gln Single submitter
- p.Glu499fs Single submitter
- p.Glu58Asp Single submitter ⚠
- p.Glu58Lys Single submitter ⚠
- p.Gly107Glu Single submitter ⚠
- p.Gly128Ser Single submitter ⚠
- p.Gly571Ala Single submitter ⚠
- p.Gly948Ala Single submitter ⚠
- p.Gly948Arg Single submitter ⚠
- p.His15Arg Single submitter ⚠
- p.His406Arg Single submitter ⚠
- p.His471Asn Single submitter ⚠
- p.Ile144Thr Single submitter ⚠
- p.Ile145Thr Single submitter ⚠
- p.Ile524Val Single submitter ⚠
- p.Ile57Met Single submitter ⚠
- p.Leu171Met Single submitter ⚠
- p.Leu171Pro Single submitter ⚠
- p.Leu415Val Single submitter
- p.Leu43Phe Single submitter ⚠
- p.Leu486Ser Single submitter ⚠
- p.Leu85Pro Single submitter ⚠
- p.Lys531Asn Single submitter ⚠
- p.Met34Ile Single submitter ⚠
- p.Met34Thr Single submitter ⚠
- p.Met34Val Single submitter ⚠
- p.Met936Leu Single submitter ⚠
- p.Phe120Ile Single submitter
- p.Phe18Val Single submitter ⚠
- p.Phe437Tyr Single submitter ⚠
- p.Pro519Ala Single submitter ⚠
- p.Ser425Phe Single submitter ⚠
- p.Ser815Cys Single submitter ⚠
- p.Ser941Leu Single submitter ⚠
- p.Ser941Pro Single submitter ⚠
- p.Thr104Met Single submitter ⚠
- p.Thr203Met Single submitter ⚠
- p.Thr224Ile Single submitter ⚠
- p.Thr261Ala Single submitter ⚠
- p.Thr389Met Single submitter
- p.Thr546Asn Single submitter ⚠
- p.Thr957Ile Single submitter ⚠
- p.Trp344Ter Single submitter
- p.Tyr235Asn Single submitter ⚠
- p.Val197Leu Single submitter ⚠
- p.Val285Ile Single submitter ⚠
- p.Val520Leu Single submitter ⚠
- p.Val84Ile Single submitter ⚠
- p.Val97Leu Single submitter ⚠