MAP3K15 — 262 ClinVar variants
All ClinVar germline MAP3K15 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 204 flagged for review →
3 Conflicting · 14 Benign · 30 Likely benign · 215 Uncertain significance
Full MAP3K15 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 204
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 3
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 156
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 156
-
MAP3K15 p.Thr1229Arg
Uncertain significance
Multiple submitters
MAP3K15-related disorder
- MAP3K15 p.Ala1255Gly Uncertain significance Single submitter
- MAP3K15 p.Ala12Asp Uncertain significance Single submitter
- MAP3K15 p.Ala300Val Uncertain significance Single submitter
- MAP3K15 p.Ala32Val Uncertain significance Single submitter
- MAP3K15 p.Ala468Val Uncertain significance Single submitter
- MAP3K15 p.Ala551Ser Uncertain significance Single submitter
- MAP3K15 p.Ala628Thr Uncertain significance Single submitter
- MAP3K15 p.Ala63Glu Uncertain significance Single submitter
- MAP3K15 p.Ala63Thr Uncertain significance Single submitter
- MAP3K15 p.Ala957Thr Uncertain significance Single submitter
- MAP3K15 p.Ala961Thr Uncertain significance Single submitter
- MAP3K15 p.Ala968Val Uncertain significance Single submitter
- MAP3K15 p.Arg1060Cys Uncertain significance Single submitter
- MAP3K15 p.Arg1065Trp Uncertain significance Single submitter
- MAP3K15 p.Arg1122Gln Uncertain significance Single submitter
- MAP3K15 p.Arg1286Trp Uncertain significance Single submitter
- MAP3K15 p.Arg269Gln Uncertain significance Single submitter
- MAP3K15 p.Arg339Gly Uncertain significance Single submitter
- MAP3K15 p.Arg429Gln Uncertain significance Single submitter
- MAP3K15 p.Arg429Gly Uncertain significance Single submitter
- MAP3K15 p.Arg436Lys Uncertain significance Single submitter
- MAP3K15 p.Arg483Gln Uncertain significance Single submitter
- MAP3K15 p.Arg493Trp Uncertain significance Single submitter
- MAP3K15 p.Arg508Gln Uncertain significance Single submitter
- MAP3K15 p.Arg554Lys Uncertain significance Single submitter
- MAP3K15 p.Arg67Ser Uncertain significance Single submitter
- MAP3K15 p.Arg896His Uncertain significance Single submitter
- MAP3K15 p.Arg918Gln Uncertain significance Single submitter
- MAP3K15 p.Arg928Pro Uncertain significance Single submitter
- MAP3K15 p.Arg967Trp Uncertain significance Single submitter
- MAP3K15 p.Asn1118Ile Uncertain significance Single submitter
- MAP3K15 p.Asn521Ser Uncertain significance Single submitter
- MAP3K15 p.Asn652His Uncertain significance Single submitter
- MAP3K15 p.Asp119Asn Uncertain significance Single submitter
- MAP3K15 p.Asp1270Tyr Uncertain significance Single submitter
- MAP3K15 p.Asp318Gly Uncertain significance Single submitter
- MAP3K15 p.Asp379Asn Uncertain significance Single submitter
- MAP3K15 p.Asp38Asn Uncertain significance Single submitter
- MAP3K15 p.Cys1033Arg Uncertain significance Single submitter
- MAP3K15 p.Cys1033Tyr Uncertain significance Single submitter
- MAP3K15 p.Cys191Gly Uncertain significance Single submitter
- MAP3K15 p.Cys191Trp Uncertain significance Single submitter
- MAP3K15 p.Gln1050Pro Uncertain significance Single submitter
- MAP3K15 p.Gln351Glu Uncertain significance Single submitter
- MAP3K15 p.Gln467Leu Uncertain significance Single submitter
- MAP3K15 p.Gln506Arg Uncertain significance Single submitter
- MAP3K15 p.Gln823His Uncertain significance Single submitter
- MAP3K15 p.Gln910Arg Uncertain significance Single submitter
- MAP3K15 p.Glu1039Lys Uncertain significance Single submitter
- MAP3K15 p.Glu1040Ala Uncertain significance Single submitter
- MAP3K15 p.Glu1040Gln Uncertain significance Single submitter
- MAP3K15 p.Glu1230Asp Uncertain significance Single submitter
- MAP3K15 p.Glu395Asp Uncertain significance Single submitter
- MAP3K15 p.Glu501Asp Uncertain significance Single submitter
- MAP3K15 p.Glu501Gly Uncertain significance Single submitter
- MAP3K15 p.Glu507Gly Uncertain significance Single submitter
- MAP3K15 p.Glu52Asp Uncertain significance Single submitter
- MAP3K15 p.Glu552Lys Uncertain significance Single submitter
- MAP3K15 p.Glu571Lys Uncertain significance Single submitter
- MAP3K15 p.Glu610Lys Uncertain significance Single submitter
- MAP3K15 p.Glu633Lys Uncertain significance Single submitter
- MAP3K15 p.Glu69Ala Uncertain significance Single submitter
- MAP3K15 p.Glu69Lys Uncertain significance Single submitter
- MAP3K15 p.Glu718Gly Uncertain significance Single submitter
- MAP3K15 p.Glu856Gln Uncertain significance Single submitter
- MAP3K15 p.Glu939Asp Uncertain significance Single submitter
- MAP3K15 p.Gly1166Ser Uncertain significance Single submitter
- MAP3K15 p.Gly11Arg Uncertain significance Single submitter
- MAP3K15 p.Gly1237Arg Uncertain significance Single submitter
- MAP3K15 p.Gly1237Trp Uncertain significance Single submitter
- MAP3K15 p.Gly365Trp Uncertain significance Single submitter
- MAP3K15 p.Gly43Asp Uncertain significance Single submitter
- MAP3K15 p.Gly55Asp Uncertain significance Single submitter
- MAP3K15 p.Gly55Cys Uncertain significance Single submitter
- MAP3K15 p.Gly581Glu Uncertain significance Single submitter
- MAP3K15 p.Gly636Ala Uncertain significance Single submitter
- MAP3K15 p.Gly640Ala Uncertain significance Single submitter
- MAP3K15 p.Gly661Val Uncertain significance Single submitter
- MAP3K15 p.Gly6Arg Uncertain significance Single submitter
- MAP3K15 p.Gly720Ala Uncertain significance Single submitter
- MAP3K15 p.Gly720Ser Uncertain significance Single submitter
- MAP3K15 p.Gly731Arg Uncertain significance Single submitter
- MAP3K15 p.Gly73Cys Uncertain significance Single submitter
- MAP3K15 p.Gly914Asp Uncertain significance Single submitter
- MAP3K15 p.His139Arg Uncertain significance Single submitter
- MAP3K15 p.His320Asp Uncertain significance Single submitter
- MAP3K15 p.His460Arg Uncertain significance Single submitter
- MAP3K15 p.His597Arg Uncertain significance Single submitter
- MAP3K15 p.His649Arg Uncertain significance Single submitter
- MAP3K15 p.His765Tyr Uncertain significance Single submitter
- MAP3K15 p.His894Tyr Uncertain significance Single submitter
- MAP3K15 p.His948Tyr Uncertain significance Single submitter
- MAP3K15 p.Ile1102Met Uncertain significance Single submitter
- MAP3K15 p.Ile1228Val Uncertain significance Single submitter
- MAP3K15 p.Ile322Val Uncertain significance Single submitter
- MAP3K15 p.Ile404Val Uncertain significance Single submitter
- MAP3K15 p.Ile499Val Uncertain significance Single submitter
- MAP3K15 p.Ile515Val Uncertain significance Single submitter
- MAP3K15 p.Ile547Val Uncertain significance Single submitter
- MAP3K15 p.Ile873Ser Uncertain significance Single submitter
- MAP3K15 p.Leu1041Ser Uncertain significance Single submitter
- MAP3K15 p.Leu1194Val Uncertain significance Single submitter
- MAP3K15 p.Leu1223Ser Uncertain significance Single submitter
- MAP3K15 p.Leu1280Pro Uncertain significance Single submitter
- MAP3K15 p.Leu140Pro Uncertain significance Single submitter
- MAP3K15 p.Leu347Phe Uncertain significance Single submitter
- MAP3K15 p.Leu643Val Uncertain significance Single submitter
- MAP3K15 p.Leu658Ser Uncertain significance Single submitter
- MAP3K15 p.Leu734Phe Uncertain significance Single submitter
- MAP3K15 p.Leu977Phe Uncertain significance Single submitter
- MAP3K15 p.Lys1017Glu Uncertain significance Single submitter
- MAP3K15 p.Lys1073Glu Uncertain significance Single submitter
- MAP3K15 p.Lys233Thr Uncertain significance Single submitter
- MAP3K15 p.Lys378Arg Uncertain significance Single submitter
- MAP3K15 p.Lys378Glu Uncertain significance Single submitter
- MAP3K15 p.Lys474Arg Uncertain significance Single submitter
- MAP3K15 p.Lys496Arg Uncertain significance Single submitter
- MAP3K15 p.Lys681Arg Uncertain significance Single submitter
- MAP3K15 p.Met209Leu Uncertain significance Single submitter
- MAP3K15 p.Met301Leu Uncertain significance Single submitter
- MAP3K15 p.Met310Ile Uncertain significance Single submitter
- MAP3K15 p.Met346Val Uncertain significance Single submitter
- MAP3K15 p.Met443Arg Uncertain significance Single submitter
- MAP3K15 p.Pro219Leu Uncertain significance Single submitter
- MAP3K15 p.Pro26Leu Uncertain significance Single submitter
- MAP3K15 p.Pro356Ala Uncertain significance Single submitter
- MAP3K15 p.Pro356Leu Uncertain significance Single submitter
- MAP3K15 p.Pro57Ser Uncertain significance Single submitter
- MAP3K15 p.Pro79Arg Uncertain significance Single submitter
- MAP3K15 p.Pro804Ala Uncertain significance Single submitter
- MAP3K15 p.Pro850Leu Uncertain significance Single submitter
- MAP3K15 p.Pro857Leu Uncertain significance Single submitter
- MAP3K15 p.Pro969Ser Uncertain significance Single submitter
- MAP3K15 p.Ser398Pro Uncertain significance Single submitter
- MAP3K15 p.Ser402Trp Uncertain significance Single submitter
- MAP3K15 p.Ser432Thr Uncertain significance Single submitter
- MAP3K15 p.Ser503Leu Uncertain significance Single submitter
- MAP3K15 p.Ser546Ala Uncertain significance Single submitter
- MAP3K15 p.Ser630Cys Uncertain significance Single submitter
- MAP3K15 p.Ser688Gly Uncertain significance Single submitter
- MAP3K15 p.Ser796Leu Uncertain significance Single submitter
- MAP3K15 p.Ser944Gly Uncertain significance Single submitter
- MAP3K15 p.Ser983Gly Uncertain significance Single submitter
- MAP3K15 p.Thr631Met Uncertain significance Single submitter
- MAP3K15 p.Thr638Asn Uncertain significance Single submitter
- MAP3K15 p.Thr642Ile Uncertain significance Single submitter
- MAP3K15 p.Thr812Ala Uncertain significance Single submitter
- MAP3K15 p.Tyr763His Uncertain significance Single submitter
- MAP3K15 p.Val188Met Uncertain significance Single submitter
Predictors split 45
The independent predictors disagree with each other — read with care.
- MAP3K15 p.Ala859Thr Uncertain significance Multiple submitters
-
MAP3K15 p.Ile295Ser
Uncertain significance
Multiple submitters
MAP3K15-related disorder
-
MAP3K15 p.Leu154Phe
Uncertain significance
Multiple submitters
MAP3K15-related disorder
-
MAP3K15 p.Ala1115Thr
Uncertain significance
Single submitter
neurodevelopmental disorder
- MAP3K15 p.Ala1127Thr Uncertain significance Single submitter
- MAP3K15 p.Arg1012His Uncertain significance Single submitter
- MAP3K15 p.Arg1249Trp Uncertain significance Single submitter
- MAP3K15 p.Arg273His Uncertain significance Single submitter
- MAP3K15 p.Arg383Cys Uncertain significance Single submitter
- MAP3K15 p.Arg429Trp Uncertain significance Single submitter
- MAP3K15 p.Arg670Gln Uncertain significance Single submitter
- MAP3K15 p.Arg84Pro Uncertain significance Single submitter
- MAP3K15 p.Asn150Asp Uncertain significance Single submitter
- MAP3K15 p.Asp159Tyr Uncertain significance Single submitter
- MAP3K15 p.Asp297His Uncertain significance Single submitter
- MAP3K15 p.Asp588His Uncertain significance Single submitter
- MAP3K15 p.Cys91Ser Uncertain significance Single submitter
- MAP3K15 p.Gln1125Leu Uncertain significance Single submitter
- MAP3K15 p.Glu1010Lys Uncertain significance Single submitter
- MAP3K15 p.Glu696Lys Uncertain significance Single submitter
- MAP3K15 p.Glu890Lys Uncertain significance Single submitter
- MAP3K15 p.Gly1265Ser Uncertain significance Single submitter
- MAP3K15 p.Ile1052Thr Uncertain significance Single submitter
- MAP3K15 p.Ile1088Ser Uncertain significance Single submitter
- MAP3K15 p.Ile1258Thr Uncertain significance Single submitter
- MAP3K15 p.Ile295Asn Uncertain significance Single submitter
- MAP3K15 p.Leu1248Phe Uncertain significance Single submitter
- MAP3K15 p.Leu1293Phe Uncertain significance Single submitter
- MAP3K15 p.Leu289Phe Uncertain significance Single submitter
- MAP3K15 p.Leu433Phe Uncertain significance Single submitter
- MAP3K15 p.Lys1007Glu Uncertain significance Single submitter
- MAP3K15 p.Met1116Thr Uncertain significance Single submitter
- MAP3K15 p.Met148Val Uncertain significance Single submitter
- MAP3K15 p.Phe324Leu Uncertain significance Single submitter
- MAP3K15 p.Phe587Leu Uncertain significance Single submitter
- MAP3K15 p.Phe889Leu Uncertain significance Single submitter
- MAP3K15 p.Pro134Ser Uncertain significance Single submitter
- MAP3K15 p.Pro748Leu Uncertain significance Single submitter
- MAP3K15 p.Pro831Thr Uncertain significance Single submitter
- MAP3K15 p.Ser691Phe Uncertain significance Single submitter
- MAP3K15 p.Thr754Ser Uncertain significance Single submitter
- MAP3K15 p.Thr795Ser Uncertain significance Single submitter
- MAP3K15 p.Val101Met Uncertain significance Single submitter
- MAP3K15 p.Val113Met Uncertain significance Single submitter
-
MAP3K15 p.Arg494Cys
Benign
No assertion criteria
MAP3K15-related disorder
All MAP3K15 variants
Conflicting classifications of pathogenicity 3
- p.Arg1302Lys Single submitter ⚠
- p.Arg1302Ser Single submitter ⚠
- p.Asp380Gly Single submitter ⚠
Benign 14
- p.Ser199Asn Multiple submitters
- c.3295-4_3295-3del No assertion criteria MAP3K15-related disorder
- c.719+9C>T No assertion criteria MAP3K15-related disorder
- p.Ala192Thr No assertion criteria MAP3K15-related disorder
- p.Ala876Gly No assertion criteria MAP3K15-related disorder
- p.Arg494Cys No assertion criteria MAP3K15-related disorder ⚠
- p.Gln692= No assertion criteria MAP3K15-related disorder
- p.Gly786Arg No assertion criteria MAP3K15-related disorder
- p.Gly838Ser No assertion criteria MAP3K15-related disorder
- p.His695= No assertion criteria MAP3K15-related disorder
- p.Ser456Gly No assertion criteria MAP3K15-related disorder
- p.Ser503= No assertion criteria MAP3K15-related disorder
- p.Ser993Leu No assertion criteria MAP3K15-related disorder
- p.Val657= No assertion criteria MAP3K15-related disorder
Likely benign 30
- p.Val455Ile Multiple submitters
- p.Ala736= Single submitter
- p.Arg1136Gln Single submitter
- p.Arg493Gln Single submitter
- p.Arg615= Single submitter
- p.Glu1039= Single submitter
- p.Leu1250= Single submitter
- p.Leu1289= Single submitter
- p.Pro219= Single submitter
- p.Pro24Leu Single submitter
- p.Pro935Ser Single submitter
- p.Pro995Leu Single submitter
- p.Ser1083= Single submitter
- p.Ser402= Single submitter
- c.1440-1G>T No assertion criteria MAP3K15-related disorder
- c.3295-4_3295-3dup No assertion criteria MAP3K15-related disorder
- c.3567-13_3567-8del No assertion criteria MAP3K15-related disorder
- p.Ala264Val No assertion criteria MAP3K15-related disorder
- p.Asp822= No assertion criteria MAP3K15-related disorder
- p.Asp956= No assertion criteria MAP3K15-related disorder
- p.Glu1200fs No assertion criteria MAP3K15-related disorder
- p.Gly776= No assertion criteria MAP3K15-related disorder
- p.His570= No assertion criteria MAP3K15-related disorder
- p.Ile184= No assertion criteria MAP3K15-related disorder
- p.Met457Leu No assertion criteria MAP3K15-related disorder
- p.Met457Val No assertion criteria MAP3K15-related disorder
- p.Ser955= No assertion criteria MAP3K15-related disorder
- p.Thr631= No assertion criteria MAP3K15-related disorder
- p.Thr642= No assertion criteria MAP3K15-related disorder
- p.Val930= No assertion criteria MAP3K15-related disorder
Uncertain significance 215
- p.Ala859Thr Multiple submitters ⚠
- p.Ile295Ser Multiple submitters MAP3K15-related disorder ⚠
- p.Leu154Phe Multiple submitters MAP3K15-related disorder ⚠
- p.Thr1229Arg Multiple submitters MAP3K15-related disorder ⚠
- c.2325+1G>T Single submitter neurodevelopmental disorder
- c.3781-7G>C Single submitter pyruvate dehydrogenase E1-alpha deficiency
- p.Ala1115Thr Single submitter neurodevelopmental disorder ⚠
- p.Ala1127Thr Single submitter ⚠
- p.Ala1255Gly Single submitter ⚠
- p.Ala12Asp Single submitter ⚠
- p.Ala300Val Single submitter ⚠
- p.Ala32Val Single submitter ⚠
- p.Ala468Val Single submitter ⚠
- p.Ala551Ser Single submitter ⚠
- p.Ala628Thr Single submitter ⚠
- p.Ala63Glu Single submitter ⚠
- p.Ala63Thr Single submitter ⚠
- p.Ala800Val Single submitter
- p.Ala957Thr Single submitter ⚠
- p.Ala961Thr Single submitter ⚠
- p.Ala968Val Single submitter ⚠
- p.Arg1012His Single submitter ⚠
- p.Arg1060Cys Single submitter ⚠
- p.Arg1065Trp Single submitter ⚠
- p.Arg1122Gln Single submitter ⚠
- p.Arg1199fs Single submitter
- p.Arg1249Trp Single submitter ⚠
- p.Arg1286Trp Single submitter ⚠
- p.Arg269Gln Single submitter ⚠
- p.Arg269Trp Single submitter
- p.Arg273His Single submitter ⚠
- p.Arg339Gly Single submitter ⚠
- p.Arg339His Single submitter
- p.Arg383Cys Single submitter ⚠
- p.Arg429Gln Single submitter ⚠
- p.Arg429Gly Single submitter ⚠
- p.Arg429Trp Single submitter ⚠
- p.Arg436Lys Single submitter ⚠
- p.Arg483Gln Single submitter ⚠
- p.Arg493Trp Single submitter ⚠
- p.Arg508Gln Single submitter ⚠
- p.Arg554Lys Single submitter ⚠
- p.Arg670Gln Single submitter ⚠
- p.Arg67Ser Single submitter ⚠
- p.Arg84Pro Single submitter ⚠
- p.Arg896His Single submitter ⚠
- p.Arg918Gln Single submitter ⚠
- p.Arg928Pro Single submitter ⚠
- p.Arg967Trp Single submitter ⚠
- p.Asn1118Ile Single submitter ⚠
- p.Asn150Asp Single submitter ⚠
- p.Asn521Ser Single submitter ⚠
- p.Asn652His Single submitter ⚠
- p.Asp119Asn Single submitter ⚠
- p.Asp1270Tyr Single submitter ⚠
- p.Asp129Tyr Single submitter
- p.Asp159Tyr Single submitter ⚠
- p.Asp297His Single submitter ⚠
- p.Asp318Gly Single submitter ⚠
- p.Asp379Asn Single submitter ⚠
- p.Asp38Asn Single submitter ⚠
- p.Asp588His Single submitter ⚠
- p.Asp777Asn Single submitter
- p.Cys1033Arg Single submitter ⚠
- p.Cys1033Tyr Single submitter ⚠
- p.Cys191Gly Single submitter ⚠
- p.Cys191Trp Single submitter ⚠
- p.Cys91Ser Single submitter ⚠
- p.Gln1050Pro Single submitter ⚠
- p.Gln1125Leu Single submitter ⚠
- p.Gln351Glu Single submitter ⚠
- p.Gln467Leu Single submitter ⚠
- p.Gln506Arg Single submitter ⚠
- p.Gln541His Single submitter
- p.Gln823His Single submitter ⚠
- p.Gln910Arg Single submitter ⚠
- p.Glu1010Lys Single submitter ⚠
- p.Glu1039Lys Single submitter ⚠
- p.Glu1040Ala Single submitter ⚠
- p.Glu1040Gln Single submitter ⚠
- p.Glu1230Asp Single submitter ⚠
- p.Glu395Asp Single submitter ⚠
- p.Glu501Asp Single submitter ⚠
- p.Glu501Gly Single submitter ⚠
- p.Glu507Gly Single submitter ⚠
- p.Glu52Asp Single submitter ⚠
- p.Glu552Lys Single submitter ⚠
- p.Glu571Lys Single submitter ⚠
- p.Glu610Lys Single submitter ⚠
- p.Glu633Lys Single submitter ⚠
- p.Glu696Lys Single submitter ⚠
- p.Glu69Ala Single submitter ⚠
- p.Glu69Lys Single submitter ⚠
- p.Glu718Gly Single submitter ⚠
- p.Glu856Gln Single submitter ⚠
- p.Glu890Lys Single submitter ⚠
- p.Glu939Asp Single submitter ⚠
- p.Gly1166Ser Single submitter ⚠
- p.Gly11Arg Single submitter ⚠
- p.Gly1237Arg Single submitter ⚠
- p.Gly1237Trp Single submitter ⚠
- p.Gly1265Ser Single submitter ⚠
- p.Gly365Trp Single submitter ⚠
- p.Gly43Asp Single submitter ⚠
- p.Gly55Asp Single submitter ⚠
- p.Gly55Cys Single submitter ⚠
- p.Gly581Glu Single submitter ⚠
- p.Gly636Ala Single submitter ⚠
- p.Gly640Ala Single submitter ⚠
- p.Gly661Val Single submitter ⚠
- p.Gly6Arg Single submitter ⚠
- p.Gly720Ala Single submitter ⚠
- p.Gly720Ser Single submitter ⚠
- p.Gly731Arg Single submitter ⚠
- p.Gly73Cys Single submitter ⚠
- p.Gly78fs Single submitter MAP3K15-related disorder
- p.Gly914Asp Single submitter ⚠
- p.His139Arg Single submitter ⚠
- p.His320Asp Single submitter ⚠
- p.His460Arg Single submitter ⚠
- p.His597Arg Single submitter ⚠
- p.His649Arg Single submitter ⚠
- p.His765Tyr Single submitter ⚠
- p.His894Tyr Single submitter ⚠
- p.His948Tyr Single submitter ⚠
- p.Ile1052Thr Single submitter ⚠
- p.Ile1088Ser Single submitter ⚠
- p.Ile1102Met Single submitter ⚠
- p.Ile1228Val Single submitter ⚠
- p.Ile1258Thr Single submitter ⚠
- p.Ile295Asn Single submitter ⚠
- p.Ile322Val Single submitter ⚠
- p.Ile404Val Single submitter ⚠
- p.Ile499Val Single submitter ⚠
- p.Ile515Val Single submitter ⚠
- p.Ile547Val Single submitter ⚠
- p.Ile873Ser Single submitter ⚠
- p.Leu1041Ser Single submitter ⚠
- p.Leu1194Val Single submitter ⚠
- p.Leu1223Ser Single submitter ⚠
- p.Leu1248Phe Single submitter ⚠
- p.Leu1280Pro Single submitter ⚠
- p.Leu1293Phe Single submitter ⚠
- p.Leu140Pro Single submitter ⚠
- p.Leu289Phe Single submitter ⚠
- p.Leu347Phe Single submitter ⚠
- p.Leu433Phe Single submitter ⚠
- p.Leu643Val Single submitter ⚠
- p.Leu658Ser Single submitter ⚠
- p.Leu734Phe Single submitter ⚠
- p.Leu977Phe Single submitter ⚠
- p.Lys1007Glu Single submitter ⚠
- p.Lys1017Glu Single submitter ⚠
- p.Lys1073Glu Single submitter ⚠
- p.Lys233Thr Single submitter ⚠
- p.Lys369fs Single submitter
- p.Lys378Arg Single submitter ⚠
- p.Lys378Glu Single submitter ⚠
- p.Lys474Arg Single submitter ⚠
- p.Lys496Arg Single submitter ⚠
- p.Lys681Arg Single submitter ⚠
- p.Met1116Thr Single submitter ⚠
- p.Met148Val Single submitter ⚠
- p.Met209Leu Single submitter ⚠
- p.Met301Leu Single submitter ⚠
- p.Met310Ile Single submitter ⚠
- p.Met346Val Single submitter ⚠
- p.Met443Arg Single submitter ⚠
- p.Phe324Leu Single submitter ⚠
- p.Phe587Leu Single submitter ⚠
- p.Phe889Leu Single submitter ⚠
- p.Pro134Ser Single submitter ⚠
- p.Pro219Leu Single submitter ⚠
- p.Pro26Leu Single submitter ⚠
- p.Pro356Ala Single submitter ⚠
- p.Pro356Leu Single submitter ⚠
- p.Pro57Ser Single submitter ⚠
- p.Pro684Leu Single submitter neurodevelopmental disorder
- p.Pro748Leu Single submitter ⚠
- p.Pro79Arg Single submitter ⚠
- p.Pro804Ala Single submitter ⚠
- p.Pro831Thr Single submitter ⚠
- p.Pro850Leu Single submitter ⚠
- p.Pro857Leu Single submitter ⚠
- p.Pro891Arg Single submitter
- p.Pro969Ser Single submitter ⚠
- p.Ser398Pro Single submitter ⚠
- p.Ser402Trp Single submitter ⚠
- p.Ser432Thr Single submitter ⚠
- p.Ser503Leu Single submitter ⚠
- p.Ser546Ala Single submitter ⚠
- p.Ser630Cys Single submitter ⚠
- p.Ser688Gly Single submitter ⚠
- p.Ser691Phe Single submitter ⚠
- p.Ser796Leu Single submitter ⚠
- p.Ser944Gly Single submitter ⚠
- p.Ser983Gly Single submitter ⚠
- p.Thr631Met Single submitter ⚠
- p.Thr638Asn Single submitter ⚠
- p.Thr642Ile Single submitter ⚠
- p.Thr662Met Single submitter
- p.Thr754Ser Single submitter ⚠
- p.Thr795Ser Single submitter ⚠
- p.Thr812Ala Single submitter ⚠
- p.Tyr763His Single submitter ⚠
- p.Val101Met Single submitter ⚠
- p.Val113Met Single submitter ⚠
- p.Val188Met Single submitter ⚠
- p.Val449Met Single submitter ⚠
- p.Val466Ile Single submitter ⚠
- p.Val770Met Single submitter ⚠
- p.Val787Met Single submitter ⚠
- p.Val931Gly Single submitter ⚠
- p.Val931Ile Single submitter ⚠
- p.Gln541Ter No assertion criteria MAP3K15-related disorder