MAP3K19 — 150 ClinVar variants

All ClinVar germline MAP3K19 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 135 flagged for review →

12 Likely benign · 138 Uncertain significance

Full MAP3K19 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 135

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 126

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 9

The independent predictors disagree with each other — read with care.

All MAP3K19 variants

Likely benign 12

p.Arg1106Gln Single submitter
p.Arg605Gln Single submitter
p.Asn124= Single submitter
p.Asn227Ser Single submitter
p.Asn317Asp Single submitter
p.Asn372Lys Single submitter
p.Glu263Lys Single submitter
p.Ile313Thr Single submitter
p.Ile470Thr Single submitter
p.Met428Ile Single submitter
p.Ser271Leu Single submitter
p.Ser884Asn Single submitter

Uncertain significance 138

p.Gln1309His Multiple submitters ⚠
p.Ala115Val Single submitter ⚠
p.Ala1214Val Single submitter ⚠
p.Ala1274Val Single submitter ⚠
p.Arg1007Thr Single submitter ⚠
p.Arg1185His Single submitter ⚠
p.Arg1272Gly Single submitter
p.Arg1283Gln Single submitter ⚠
p.Arg1302Cys Single submitter ⚠
p.Arg1302His Single submitter ⚠
p.Arg139Trp Single submitter ⚠
p.Arg176Gly Single submitter ⚠
p.Arg253His Single submitter ⚠
p.Arg357Gln Single submitter ⚠
p.Arg473Lys Single submitter ⚠
p.Arg605Trp Single submitter ⚠
p.Arg679Thr Single submitter ⚠
p.Arg686Cys Single submitter ⚠
p.Arg686His Single submitter ⚠
p.Arg88Lys Single submitter ⚠
p.Asn227Asp Single submitter ⚠
p.Asn262Asp Single submitter ⚠
p.Asn519Lys Single submitter ⚠
p.Asn699Asp Single submitter ⚠
p.Asn950Asp Single submitter ⚠
p.Asp1034Gly Single submitter ⚠
p.Asp1204Asn Single submitter ⚠
p.Asp20Val Single submitter ⚠
p.Asp680Glu Single submitter ⚠
p.Asp854Gly Single submitter ⚠
p.Asp984Glu Single submitter ⚠
p.Cys437Phe Single submitter ⚠
p.Cys627Arg Single submitter ⚠
p.Gln1172Ter Single submitter
p.Gln300Lys Single submitter ⚠
p.Gln633Lys Single submitter ⚠
p.Gln768Arg Single submitter ⚠
p.Gln790Glu Single submitter ⚠
p.Gln869His Single submitter ⚠
p.Gln912Lys Single submitter ⚠
p.Glu130Gly Single submitter ⚠
p.Glu191Gly Single submitter ⚠
p.Glu429Gly Single submitter ⚠
p.Glu525Gln Single submitter ⚠
p.Glu557Lys Single submitter ⚠
p.Glu963Asp Single submitter ⚠
p.Gly1073Ser Single submitter ⚠
p.Gly1145Ser Single submitter ⚠
p.Gly1218Asp Single submitter ⚠
p.Gly1280Arg Single submitter ⚠
p.Gly220Val Single submitter ⚠
p.Gly69Arg Single submitter ⚠
p.His1282Arg Single submitter ⚠
p.His1321Arg Single submitter ⚠
p.His486Leu Single submitter ⚠
p.His516Arg Single submitter ⚠
p.His673Gln Single submitter ⚠
p.His845Gln Single submitter ⚠
p.Ile1032Thr Single submitter ⚠
p.Ile1047Val Single submitter ⚠
p.Ile1059Leu Single submitter ⚠
p.Ile1170Thr Single submitter ⚠
p.Ile1279Leu Single submitter
p.Ile224Val Single submitter ⚠
p.Ile238Val Single submitter ⚠
p.Ile452Thr Single submitter ⚠
p.Ile485Val Single submitter ⚠
p.Ile688Met Single submitter ⚠
p.Ile756Thr Single submitter ⚠
p.Ile769Val Single submitter ⚠
p.Ile809Thr Single submitter ⚠
p.Leu1060Pro Single submitter ⚠
p.Leu1067Val Single submitter ⚠
p.Leu1115Pro Single submitter ⚠
p.Leu1158Ser Single submitter ⚠
p.Leu131Arg Single submitter ⚠
p.Leu166Ser Single submitter ⚠
p.Leu330Phe Single submitter ⚠
p.Leu980Phe Single submitter ⚠
p.Leu980Pro Single submitter ⚠
p.Lys1168Glu Single submitter ⚠
p.Lys1264Arg Single submitter ⚠
p.Lys1264Glu Single submitter ⚠
p.Lys135Arg Single submitter ⚠
p.Lys424Ile Single submitter ⚠
p.Lys496Arg Single submitter ⚠
p.Lys611Met Single submitter ⚠
p.Lys645Glu Single submitter ⚠
p.Lys724Thr Single submitter ⚠
p.Lys935Asn Single submitter ⚠
p.Met1195Val Single submitter ⚠
p.Met428Leu Single submitter ⚠
p.Met428Val Single submitter ⚠
p.Met462Lys Single submitter ⚠
p.Met564Ile Single submitter ⚠
p.Met796Val Single submitter ⚠
p.Met957Val Single submitter ⚠
p.Met991Thr Single submitter ⚠
p.Phe1155Leu Single submitter ⚠
p.Phe1293Val Single submitter ⚠
p.Pro1196Ser Single submitter ⚠
p.Pro521Ser Single submitter ⚠
p.Pro549Thr Single submitter ⚠
p.Pro575Leu Single submitter ⚠
p.Pro584Ser Single submitter ⚠
p.Pro595Arg Single submitter ⚠
p.Pro629Leu Single submitter ⚠
p.Pro93Leu Single submitter ⚠
p.Ser110Leu Single submitter ⚠
p.Ser1269Phe Single submitter ⚠
p.Ser201Asn Single submitter ⚠
p.Ser219Pro Single submitter ⚠
p.Ser279Phe Single submitter ⚠
p.Ser540Leu Single submitter ⚠
p.Ser808Cys Single submitter ⚠
p.Ser855Arg Single submitter ⚠
p.Ser860Asn Single submitter ⚠
p.Ser877Thr Single submitter ⚠
p.Ser879Arg Single submitter ⚠
p.Thr217Ala Single submitter ⚠
p.Thr464Ala Single submitter ⚠
p.Thr556Ala Single submitter ⚠
p.Thr58Pro Single submitter ⚠
p.Thr945Ile Single submitter ⚠
p.Trp1061Cys Single submitter ⚠
p.Trp1213Gly Single submitter ⚠
p.Trp73Arg Single submitter ⚠
p.Trp767Cys Single submitter ⚠
p.Tyr1033Cys Single submitter ⚠
p.Tyr1072His Single submitter ⚠
p.Tyr646Asp Single submitter ⚠
p.Tyr646Cys Single submitter ⚠
p.Tyr684His Single submitter ⚠
p.Val1003Ala Single submitter ⚠
p.Val1112Ile Single submitter ⚠
p.Val344Ile Single submitter ⚠
p.Val387Ala Single submitter ⚠
p.Val632Leu Single submitter ⚠