MAP3K2 — 51 ClinVar variants
All ClinVar germline MAP3K2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 46 flagged for review →
2 Benign · 49 Uncertain significance
Full MAP3K2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 46
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MAP3K2 p.Ala178Val Uncertain significance Single submitter
- MAP3K2 p.Ala487Thr Uncertain significance Single submitter
- MAP3K2 p.Arg151Trp Uncertain significance Single submitter
- MAP3K2 p.Arg328Lys Uncertain significance Single submitter
- MAP3K2 p.Arg465His Uncertain significance Single submitter
- MAP3K2 p.Arg596Trp Uncertain significance Single submitter
- MAP3K2 p.Asn458Lys Uncertain significance Single submitter
- MAP3K2 p.Asn86Ser Uncertain significance Single submitter
- MAP3K2 p.Asp392Asn Uncertain significance Single submitter
- MAP3K2 p.Gln12Lys Uncertain significance Single submitter
- MAP3K2 p.Glu131Lys Uncertain significance Single submitter
- MAP3K2 p.Glu66Lys Uncertain significance Single submitter
- MAP3K2 p.Gly259Val Uncertain significance Single submitter
- MAP3K2 p.Gly443Ser Uncertain significance Single submitter
- MAP3K2 p.Ile110Val Uncertain significance Single submitter
- MAP3K2 p.Ile154Met Uncertain significance Single submitter
- MAP3K2 p.Ile544Val Uncertain significance Single submitter
- MAP3K2 p.Leu130Ile Uncertain significance Single submitter
- MAP3K2 p.Lys231Glu Uncertain significance Single submitter
- MAP3K2 p.Lys581Glu Uncertain significance Single submitter
- MAP3K2 p.Met518Ile Uncertain significance Single submitter
- MAP3K2 p.Phe436Tyr Uncertain significance Single submitter
- MAP3K2 p.Pro253Leu Uncertain significance Single submitter
- MAP3K2 p.Ser311Thr Uncertain significance Single submitter
- MAP3K2 p.Ser35Phe Uncertain significance Single submitter
- MAP3K2 p.Ser529Cys Uncertain significance Single submitter
- MAP3K2 p.Thr142Arg Uncertain significance Single submitter
- MAP3K2 p.Tyr538Cys Uncertain significance Single submitter
- MAP3K2 p.Tyr589His Uncertain significance Single submitter
- MAP3K2 p.Tyr618His Uncertain significance Single submitter
- MAP3K2 p.Val120Leu Uncertain significance Single submitter
- MAP3K2 p.Val270Ile Uncertain significance Single submitter
- MAP3K2 p.Val400Gly Uncertain significance Single submitter
- MAP3K2 p.Val44Ile Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- MAP3K2 p.Ala607Thr Uncertain significance Single submitter
- MAP3K2 p.Arg286Ile Uncertain significance Single submitter
- MAP3K2 p.Arg69Gly Uncertain significance Single submitter
- MAP3K2 p.Asp375Asn Uncertain significance Single submitter
- MAP3K2 p.Cys512Ser Uncertain significance Single submitter
- MAP3K2 p.Gly313Arg Uncertain significance Single submitter
- MAP3K2 p.Ile186Asn Uncertain significance Single submitter
- MAP3K2 p.Ile511Ser Uncertain significance Single submitter
- MAP3K2 p.Leu455Phe Uncertain significance Single submitter
- MAP3K2 p.Leu7Phe Uncertain significance Single submitter
- MAP3K2 p.Lys506Ile Uncertain significance Single submitter
- MAP3K2 p.Ser114Asn Uncertain significance Single submitter
All MAP3K2 variants
Uncertain significance 49
- p.Ala178Val Single submitter ⚠
- p.Ala487Thr Single submitter ⚠
- p.Ala607Thr Single submitter ⚠
- p.Arg151Trp Single submitter ⚠
- p.Arg286Ile Single submitter ⚠
- p.Arg328Lys Single submitter ⚠
- p.Arg465His Single submitter ⚠
- p.Arg596Trp Single submitter ⚠
- p.Arg69Gly Single submitter ⚠
- p.Asn458Lys Single submitter ⚠
- p.Asn86Ser Single submitter ⚠
- p.Asp375Asn Single submitter ⚠
- p.Asp392Asn Single submitter ⚠
- p.Cys512Ser Single submitter ⚠
- p.Gln12Lys Single submitter ⚠
- p.Glu131Lys Single submitter ⚠
- p.Glu66Lys Single submitter ⚠
- p.Gly259Val Single submitter ⚠
- p.Gly313Arg Single submitter ⚠
- p.Gly443Ser Single submitter ⚠
- p.Ile110Val Single submitter ⚠
- p.Ile154Met Single submitter ⚠
- p.Ile186Asn Single submitter ⚠
- p.Ile511Ser Single submitter ⚠
- p.Ile544Val Single submitter ⚠
- p.Leu130Ile Single submitter ⚠
- p.Leu130Ter Single submitter
- p.Leu455Phe Single submitter ⚠
- p.Leu7Phe Single submitter ⚠
- p.Lys231Glu Single submitter ⚠
- p.Lys506Ile Single submitter ⚠
- p.Lys581Glu Single submitter ⚠
- p.Met518Ile Single submitter ⚠
- p.Phe436Tyr Single submitter ⚠
- p.Pro253Leu Single submitter ⚠
- p.Ser114Asn Single submitter ⚠
- p.Ser311Thr Single submitter ⚠
- p.Ser35Phe Single submitter ⚠
- p.Ser529Cys Single submitter ⚠
- p.Thr142Arg Single submitter ⚠
- p.Tyr371Cys Single submitter
- p.Tyr538Cys Single submitter ⚠
- p.Tyr589His Single submitter ⚠
- p.Tyr618His Single submitter ⚠
- p.Val120Leu Single submitter ⚠
- p.Val270Ile Single submitter ⚠
- p.Val400Gly Single submitter ⚠
- p.Val44Ile Single submitter ⚠
- p.Met567Val No assertion criteria MAP3K2-related condition