MAP3K4 — 200 ClinVar variants

All ClinVar germline MAP3K4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 181 flagged for review →

1 Conflicting · 2 Benign · 7 Likely benign · 190 Uncertain significance

Full MAP3K4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 181

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

MAP3K4 p.Arg1007His Conflicting Single submitter

Predictors lean, ClinVar uncertain 147

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 33

The independent predictors disagree with each other — read with care.

All MAP3K4 variants

Conflicting classifications of pathogenicity 1

p.Arg1007His Single submitter ⚠

Benign 2

c.4236+7C>T Single submitter
p.Asn1003Lys Single submitter

Likely benign 7

p.Pro64Ser Multiple submitters
c.3136-4A>C Single submitter
p.Gln584His Single submitter
p.Gly316Ser Single submitter
p.Ile334Thr Single submitter
p.Ile478Val Single submitter
p.Tyr1066= Single submitter

Uncertain significance 190

c.3525-1G>A Single submitter
c.3674+1G>A Single submitter
p.Ala1004Thr Single submitter ⚠
p.Ala1070Ser Single submitter ⚠
p.Ala1105Val Single submitter ⚠
p.Ala1183Thr Single submitter ⚠
p.Ala119Val Single submitter ⚠
p.Ala1201Val Single submitter ⚠
p.Ala1288Pro Single submitter ⚠
p.Ala21Asp Single submitter ⚠
p.Ala4Thr Single submitter ⚠
p.Ala775Val Single submitter ⚠
p.Ala953Val Single submitter ⚠
p.Ala984Thr Single submitter ⚠
p.Arg1007Cys Single submitter ⚠
p.Arg1007Gly Single submitter ⚠
p.Arg110Gln Single submitter ⚠
p.Arg1204Gln Single submitter ⚠
p.Arg1272Gly Single submitter
p.Arg1278Trp Single submitter
p.Arg147Gln Single submitter ⚠
p.Arg155His Single submitter ⚠
p.Arg208Lys Single submitter ⚠
p.Arg346His Single submitter ⚠
p.Arg356Gln Single submitter ⚠
p.Arg356Leu Single submitter ⚠
p.Arg556Gly Single submitter ⚠
p.Arg558Cys Single submitter
p.Arg566Cys Single submitter ⚠
p.Arg909Gly Single submitter ⚠
p.Arg90Gly Single submitter ⚠
p.Arg911Cys Single submitter ⚠
p.Arg94His Single submitter ⚠
p.Arg94Leu Single submitter
p.Arg959Gly Single submitter ⚠
p.Asn103His Single submitter ⚠
p.Asn1075Ser Single submitter ⚠
p.Asn121Tyr Single submitter ⚠
p.Asn1452Ser Single submitter ⚠
p.Asn195Ser Single submitter ⚠
p.Asn418Ser Single submitter ⚠
p.Asn79Tyr Single submitter ⚠
p.Asn992Asp Single submitter ⚠
p.Asn992Ser Single submitter ⚠
p.Asp1182Gly Single submitter ⚠
p.Asp1182His Single submitter ⚠
p.Asp183Ala Single submitter ⚠
p.Asp279Asn Single submitter ⚠
p.Asp313Gly Single submitter ⚠
p.Asp73Asn Single submitter ⚠
p.Asp898Asn Single submitter ⚠
p.Asp915Asn Single submitter ⚠
p.Asp943Asn Single submitter ⚠
p.Asp993Gly Single submitter ⚠
p.Cys46Phe Single submitter ⚠
p.Cys47Arg Single submitter ⚠
p.Cys47Gly Single submitter ⚠
p.Cys630Ser Single submitter ⚠
p.Cys888Ser Single submitter ⚠
p.Gln1029Pro Single submitter ⚠
p.Gln1298Arg Single submitter ⚠
p.Gln1594Pro Single submitter ⚠
p.Gln345Arg Single submitter ⚠
p.Gln674Arg Single submitter ⚠
p.Gln951Arg Single submitter ⚠
p.Gln963Arg Single submitter ⚠
p.Gln964Lys Single submitter ⚠
p.Glu1241Gln Single submitter ⚠
p.Glu1295Lys Single submitter ⚠
p.Glu1373Val Single submitter ⚠
p.Glu39Lys Single submitter ⚠
p.Glu498Lys Single submitter ⚠
p.Glu514Gly Single submitter ⚠
p.Glu593Gln Single submitter ⚠
p.Glu613Lys Single submitter ⚠
p.Glu735Gly Single submitter ⚠
p.Glu767Gly Single submitter ⚠
p.Glu78Asp Single submitter ⚠
p.Glu975Gly Single submitter ⚠
p.Gly1210Asp Single submitter ⚠
p.Gly1265Val Single submitter ⚠
p.Gly1483Val Single submitter ⚠
p.Gly172Val Single submitter ⚠
p.Gly437Ser Single submitter ⚠
p.Gly437Val Single submitter ⚠
p.Gly743Glu Single submitter ⚠
p.Gly756Arg Single submitter
p.His1047Gln Single submitter ⚠
p.His1128Gln Single submitter ⚠
p.His1158Gln Single submitter ⚠
p.His1186Arg Single submitter ⚠
p.His125Arg Single submitter ⚠
p.His343Pro Single submitter ⚠
p.Ile1001Val Single submitter ⚠
p.Ile1062Thr Single submitter ⚠
p.Ile1107Ser Single submitter ⚠
p.Ile179Val Single submitter ⚠
p.Ile206Thr Single submitter ⚠
p.Ile206Val Single submitter ⚠
p.Ile277Thr Single submitter ⚠
p.Ile294Thr Single submitter ⚠
p.Ile687Thr Single submitter ⚠
p.Ile736Thr Single submitter ⚠
p.Leu414Val Single submitter ⚠
p.Leu494Phe Single submitter ⚠
p.Leu497Pro Single submitter ⚠
p.Leu504Phe Single submitter ⚠
p.Leu542Phe Single submitter ⚠
p.Leu546Phe Single submitter ⚠
p.Leu56Trp Single submitter ⚠
p.Leu750Phe Single submitter ⚠
p.Leu877Val Single submitter ⚠
p.Leu945Ile Single submitter ⚠
p.Lys1061Arg Single submitter ⚠
p.Lys1080Arg Single submitter ⚠
p.Lys1216Arg Single submitter ⚠
p.Lys126Thr Single submitter ⚠
p.Lys1315Asn Single submitter ⚠
p.Lys1356Thr Single submitter ⚠
p.Lys1385Glu Single submitter ⚠
p.Lys333Arg Single submitter ⚠
p.Lys380Arg Single submitter ⚠
p.Lys417Asn Single submitter ⚠
p.Lys846Arg Single submitter ⚠
p.Met1011Ile Single submitter ⚠
p.Met1036Val Single submitter ⚠
p.Met117Thr Single submitter ⚠
p.Met204Ile Single submitter ⚠
p.Met577Ile Single submitter ⚠
p.Met577Leu Single submitter ⚠
p.Met577Thr Single submitter ⚠
p.Met665Ile Single submitter ⚠
p.Met672Val Single submitter ⚠
p.Met697Ile Single submitter ⚠
p.Met92Arg Single submitter ⚠
p.Pro11Ser Single submitter ⚠
p.Pro1230Thr Single submitter ⚠
p.Pro12Ser Single submitter ⚠
p.Pro1586Thr Single submitter ⚠
p.Pro199Ala Single submitter ⚠
p.Pro203Ser Single submitter ⚠
p.Pro205Arg Single submitter ⚠
p.Pro205Leu Single submitter ⚠
p.Pro27Ser Single submitter ⚠
p.Pro30Ser Single submitter ⚠
p.Pro31Ser Single submitter ⚠
p.Pro32Ser Single submitter ⚠
p.Pro34Leu Single submitter ⚠
p.Pro64His Single submitter ⚠
p.Pro716Thr Single submitter ⚠
p.Pro86Arg Single submitter ⚠
p.Pro924Arg Single submitter ⚠
p.Ser1023Tyr Single submitter ⚠
p.Ser1117Asn Single submitter ⚠
p.Ser1159Gly Single submitter ⚠
p.Ser1203Thr Single submitter ⚠
p.Ser1212Pro Single submitter ⚠
p.Ser1228Asn Single submitter ⚠
p.Ser1268Gly Single submitter ⚠
p.Ser1282Cys Single submitter ⚠
p.Ser1284Gly Single submitter ⚠
p.Ser1362Cys Single submitter ⚠
p.Ser1584Arg Single submitter ⚠
p.Ser486Leu Single submitter ⚠
p.Ser524Phe Single submitter ⚠
p.Ser597Arg Single submitter ⚠
p.Ser63Gly Single submitter ⚠
p.Ser72Tyr Single submitter ⚠
p.Ser785Ile Single submitter ⚠
p.Ser952Pro Single submitter ⚠
p.Thr1324Arg Single submitter
p.Thr152Ala Single submitter ⚠
p.Thr300Ile Single submitter ⚠
p.Thr458Met Single submitter ⚠
p.Thr55Ile Single submitter ⚠
p.Thr588Ser Single submitter ⚠
p.Thr75Lys Single submitter ⚠
p.Thr77Arg Single submitter ⚠
p.Thr977Ile Single submitter
p.Tyr1328Cys Single submitter ⚠
p.Tyr138His Single submitter ⚠
p.Tyr1556Cys Single submitter ⚠
p.Tyr368Phe Single submitter
p.Tyr669His Single submitter ⚠
p.Tyr900Cys Single submitter ⚠
p.Val1200Ala Single submitter ⚠
p.Val1229Phe Single submitter ⚠
p.Val471Ile Single submitter ⚠
p.Val844Ala Single submitter ⚠
p.Val895Ile Single submitter ⚠