MAP3K5 — 123 ClinVar variants
All ClinVar germline MAP3K5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 108 flagged for review →
7 Benign · 6 Likely benign · 110 Uncertain significance
Full MAP3K5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 108
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 87
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MAP3K5 p.Ala1166Val Uncertain significance Single submitter
- MAP3K5 p.Ala1322Val Uncertain significance Single submitter
- MAP3K5 p.Ala283Val Uncertain significance Single submitter
- MAP3K5 p.Ala909Thr Uncertain significance Single submitter
- MAP3K5 p.Arg1014Gln Uncertain significance Single submitter
- MAP3K5 p.Arg1239Trp Uncertain significance Single submitter
- MAP3K5 p.Arg1272Gly Uncertain significance Single submitter
- MAP3K5 p.Arg1353Gly Uncertain significance Single submitter
- MAP3K5 p.Arg256His Uncertain significance Single submitter
- MAP3K5 p.Arg273Gln Uncertain significance Single submitter
- MAP3K5 p.Arg284His Uncertain significance Single submitter
- MAP3K5 p.Arg802Gln Uncertain significance Single submitter
- MAP3K5 p.Arg802Trp Uncertain significance Single submitter
- MAP3K5 p.Arg80Gln Uncertain significance Single submitter
- MAP3K5 p.Asn1024Ser Uncertain significance Single submitter
- MAP3K5 p.Asn1139Ser Uncertain significance Single submitter
- MAP3K5 p.Asn278Ser Uncertain significance Single submitter
- MAP3K5 p.Asn489Ser Uncertain significance Single submitter
- MAP3K5 p.Asn56Asp Uncertain significance Single submitter
- MAP3K5 p.Asp344Asn Uncertain significance Single submitter
- MAP3K5 p.Asp373Gly Uncertain significance Single submitter
- MAP3K5 p.Asp403Gly Uncertain significance Single submitter
- MAP3K5 p.Asp553Asn Uncertain significance Single submitter
- MAP3K5 p.Asp632Asn Uncertain significance Single submitter
- MAP3K5 p.Asp665His Uncertain significance Single submitter
- MAP3K5 p.Asp931Asn Uncertain significance Single submitter
- MAP3K5 p.Gln380Glu Uncertain significance Single submitter
- MAP3K5 p.Glu338Gln Uncertain significance Single submitter
- MAP3K5 p.Glu663Gly Uncertain significance Single submitter
- MAP3K5 p.Gly1012Arg Uncertain significance Single submitter
- MAP3K5 p.Gly658Arg Uncertain significance Single submitter
- MAP3K5 p.Gly742Asp Uncertain significance Single submitter
- MAP3K5 p.Gly806Asp Uncertain significance Single submitter
- MAP3K5 p.Gly831Ser Uncertain significance Single submitter
- MAP3K5 p.Gly983Ser Uncertain significance Single submitter
- MAP3K5 p.His1238Tyr Uncertain significance Single submitter
- MAP3K5 p.His348Arg Uncertain significance Single submitter
- MAP3K5 p.His414Arg Uncertain significance Single submitter
- MAP3K5 p.Ile1366Leu Uncertain significance Single submitter
- MAP3K5 p.Ile258Asn Uncertain significance Single submitter
- MAP3K5 p.Ile577Val Uncertain significance Single submitter
- MAP3K5 p.Ile708Val Uncertain significance Single submitter
- MAP3K5 p.Ile832Val Uncertain significance Single submitter
- MAP3K5 p.Ile871Ser Uncertain significance Single submitter
- MAP3K5 p.Ile915Met Uncertain significance Single submitter
- MAP3K5 p.Leu1286Phe Uncertain significance Single submitter
- MAP3K5 p.Lys134Arg Uncertain significance Single submitter
- MAP3K5 p.Lys939Glu Uncertain significance Single submitter
- MAP3K5 p.Lys943Arg Uncertain significance Single submitter
- MAP3K5 p.Met1070Val Uncertain significance Single submitter
- MAP3K5 p.Met156Lys Uncertain significance Single submitter
- MAP3K5 p.Met205Leu Uncertain significance Single submitter
- MAP3K5 p.Met231Val Uncertain significance Single submitter
- MAP3K5 p.Pro848Ser Uncertain significance Single submitter
- MAP3K5 p.Ser1234Phe Uncertain significance Single submitter
- MAP3K5 p.Ser1311Pro Uncertain significance Single submitter
- MAP3K5 p.Ser189Leu Uncertain significance Single submitter
- MAP3K5 p.Ser275Cys Uncertain significance Single submitter
- MAP3K5 p.Ser320Phe Uncertain significance Single submitter
- MAP3K5 p.Ser347Ala Uncertain significance Single submitter
- MAP3K5 p.Ser605Ile Uncertain significance Single submitter
- MAP3K5 p.Ser660Asn Uncertain significance Single submitter
- MAP3K5 p.Ser745Ile Uncertain significance Single submitter
- MAP3K5 p.Ser908Phe Uncertain significance Single submitter
- MAP3K5 p.Ser952Pro Uncertain significance Single submitter
- MAP3K5 p.Ser978Gly Uncertain significance Single submitter
- MAP3K5 p.Thr1059Lys Uncertain significance Single submitter
- MAP3K5 p.Thr1059Met Uncertain significance Single submitter
- MAP3K5 p.Thr1314Asn Uncertain significance Single submitter
- MAP3K5 p.Thr204Ala Uncertain significance Single submitter
- MAP3K5 p.Thr211Ala Uncertain significance Single submitter
- MAP3K5 p.Thr529Ile Uncertain significance Single submitter
- MAP3K5 p.Thr690Ile Uncertain significance Single submitter
- MAP3K5 p.Thr77Ile Uncertain significance Single submitter
- MAP3K5 p.Thr870Lys Uncertain significance Single submitter
- MAP3K5 p.Thr989Met Uncertain significance Single submitter
- MAP3K5 p.Tyr1343Phe Uncertain significance Single submitter
- MAP3K5 p.Tyr675Cys Uncertain significance Single submitter
- MAP3K5 p.Val1230Met Uncertain significance Single submitter
- MAP3K5 p.Val1243Ala Uncertain significance Single submitter
- MAP3K5 p.Val1243Leu Uncertain significance Single submitter
- MAP3K5 p.Val1340Ile Uncertain significance Single submitter
- MAP3K5 p.Val263Met Uncertain significance Single submitter
- MAP3K5 p.Val379Gly Uncertain significance Single submitter
- MAP3K5 p.Val38Ala Uncertain significance Single submitter
- MAP3K5 p.Val486Ile Uncertain significance Single submitter
- MAP3K5 p.Val556Ala Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- MAP3K5 p.Ala1162Val Uncertain significance Single submitter
- MAP3K5 p.Ala422Pro Uncertain significance Single submitter
- MAP3K5 p.Arg273Trp Uncertain significance Single submitter
- MAP3K5 p.Asp1038Tyr Uncertain significance Single submitter
- MAP3K5 p.Asp1118Gly Uncertain significance Single submitter
- MAP3K5 p.Asp1156Asn Uncertain significance Single submitter
- MAP3K5 p.Glu295Lys Uncertain significance Single submitter
- MAP3K5 p.Glu307Lys Uncertain significance Single submitter
- MAP3K5 p.Ile799Val Uncertain significance Single submitter
- MAP3K5 p.Leu1284Val Uncertain significance Single submitter
- MAP3K5 p.Leu762Val Uncertain significance Single submitter
- MAP3K5 p.Lys551Glu Uncertain significance Single submitter
- MAP3K5 p.Lys616Thr Uncertain significance Single submitter
- MAP3K5 p.Met1152Thr Uncertain significance Single submitter
- MAP3K5 p.Phe1369Leu Uncertain significance Single submitter
- MAP3K5 p.Phe423Tyr Uncertain significance Single submitter
- MAP3K5 p.Phe892Leu Uncertain significance Single submitter
- MAP3K5 p.Tyr677Asp Uncertain significance Single submitter
- MAP3K5 p.Val1163Leu Uncertain significance Single submitter
- MAP3K5 p.Val1223Met Uncertain significance Single submitter
- MAP3K5 p.Val455Ala Uncertain significance Single submitter
All MAP3K5 variants
Benign 7
- c.1838+9C>T Single submitter
- c.2150+10T>C Single submitter
- c.2278+8A>G Single submitter
- p.Ala1107= Single submitter
- p.Cys1005= Single submitter
- p.Glu499= Single submitter
- p.Ile1250Val Single submitter
Likely benign 6
- p.Gly39= Single submitter
- p.Gly41= Single submitter
- p.Ile1091Val Single submitter
- p.Ile1367Thr Single submitter
- p.Ile217Val Single submitter
- p.Ser1236Asn Single submitter
Uncertain significance 110
- p.Ala1162Val Single submitter ⚠
- p.Ala1166Val Single submitter ⚠
- p.Ala1322Val Single submitter ⚠
- p.Ala283Val Single submitter ⚠
- p.Ala422Pro Single submitter ⚠
- p.Ala909Thr Single submitter ⚠
- p.Arg1014Gln Single submitter ⚠
- p.Arg1239Trp Single submitter ⚠
- p.Arg1272Gly Single submitter ⚠
- p.Arg1353Gly Single submitter ⚠
- p.Arg256His Single submitter ⚠
- p.Arg273Gln Single submitter ⚠
- p.Arg273Trp Single submitter ⚠
- p.Arg284His Single submitter ⚠
- p.Arg802Gln Single submitter ⚠
- p.Arg802Trp Single submitter ⚠
- p.Arg80Gln Single submitter ⚠
- p.Asn1024Ser Single submitter ⚠
- p.Asn1139Ser Single submitter ⚠
- p.Asn278Ser Single submitter ⚠
- p.Asn489Ser Single submitter ⚠
- p.Asn56Asp Single submitter ⚠
- p.Asp1038Tyr Single submitter ⚠
- p.Asp1118Gly Single submitter ⚠
- p.Asp1156Asn Single submitter ⚠
- p.Asp344Asn Single submitter ⚠
- p.Asp373Gly Single submitter ⚠
- p.Asp403Gly Single submitter ⚠
- p.Asp553Asn Single submitter ⚠
- p.Asp632Asn Single submitter ⚠
- p.Asp665His Single submitter ⚠
- p.Asp931Asn Single submitter ⚠
- p.Gln380Glu Single submitter ⚠
- p.Glu295Lys Single submitter ⚠
- p.Glu307Lys Single submitter ⚠
- p.Glu338Gln Single submitter ⚠
- p.Glu663Gly Single submitter ⚠
- p.Gly1012Arg Single submitter ⚠
- p.Gly658Arg Single submitter ⚠
- p.Gly742Asp Single submitter ⚠
- p.Gly806Asp Single submitter ⚠
- p.Gly831Ser Single submitter ⚠
- p.Gly983Ser Single submitter ⚠
- p.His1238Tyr Single submitter ⚠
- p.His348Arg Single submitter ⚠
- p.His414Arg Single submitter ⚠
- p.Ile1366Leu Single submitter ⚠
- p.Ile258Asn Single submitter ⚠
- p.Ile577Val Single submitter ⚠
- p.Ile708Val Single submitter ⚠
- p.Ile799Val Single submitter ⚠
- p.Ile832Val Single submitter ⚠
- p.Ile871Ser Single submitter ⚠
- p.Ile915Met Single submitter ⚠
- p.Leu1284Val Single submitter ⚠
- p.Leu1286Phe Single submitter ⚠
- p.Leu762Val Single submitter ⚠
- p.Lys1140Glu Single submitter
- p.Lys134Arg Single submitter ⚠
- p.Lys551Glu Single submitter ⚠
- p.Lys616Thr Single submitter ⚠
- p.Lys939Glu Single submitter ⚠
- p.Lys943Arg Single submitter ⚠
- p.Met1070Val Single submitter ⚠
- p.Met1152Thr Single submitter ⚠
- p.Met156Lys Single submitter ⚠
- p.Met205Leu Single submitter ⚠
- p.Met231Val Single submitter ⚠
- p.Phe1369Leu Single submitter ⚠
- p.Phe423Tyr Single submitter ⚠
- p.Phe892Leu Single submitter ⚠
- p.Pro219Leu Single submitter
- p.Pro848Ser Single submitter ⚠
- p.Ser1234Phe Single submitter ⚠
- p.Ser1311Pro Single submitter ⚠
- p.Ser189Leu Single submitter ⚠
- p.Ser275Cys Single submitter ⚠
- p.Ser320Phe Single submitter ⚠
- p.Ser347Ala Single submitter ⚠
- p.Ser605Ile Single submitter ⚠
- p.Ser660Asn Single submitter ⚠
- p.Ser745Ile Single submitter ⚠
- p.Ser908Phe Single submitter ⚠
- p.Ser952Pro Single submitter ⚠
- p.Ser978Gly Single submitter ⚠
- p.Thr1059Lys Single submitter ⚠
- p.Thr1059Met Single submitter ⚠
- p.Thr1314Asn Single submitter ⚠
- p.Thr204Ala Single submitter ⚠
- p.Thr211Ala Single submitter ⚠
- p.Thr529Ile Single submitter ⚠
- p.Thr690Ile Single submitter ⚠
- p.Thr77Ile Single submitter ⚠
- p.Thr870Lys Single submitter ⚠
- p.Thr989Met Single submitter ⚠
- p.Tyr1343Phe Single submitter ⚠
- p.Tyr675Cys Single submitter ⚠
- p.Tyr677Asp Single submitter ⚠
- p.Val1163Leu Single submitter ⚠
- p.Val1223Met Single submitter ⚠
- p.Val1230Met Single submitter ⚠
- p.Val1243Ala Single submitter ⚠
- p.Val1243Leu Single submitter ⚠
- p.Val1340Ile Single submitter ⚠
- p.Val263Met Single submitter ⚠
- p.Val379Gly Single submitter ⚠
- p.Val38Ala Single submitter ⚠
- p.Val455Ala Single submitter ⚠
- p.Val486Ile Single submitter ⚠
- p.Val556Ala Single submitter ⚠