MAP3K8 — 273 ClinVar variants
All ClinVar germline MAP3K8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 125 flagged for review →
5 Conflicting · 17 Benign · 7 Benign/Likely benign · 111 Likely benign · 133 Uncertain significance
Full MAP3K8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 125
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 4
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 97
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MAP3K8 p.Ala35Ser Uncertain significance Multiple submitters
- MAP3K8 p.Arg392Gly Uncertain significance Multiple submitters
- MAP3K8 p.Arg408Ser Uncertain significance Multiple submitters
- MAP3K8 p.Asn54Asp Uncertain significance Multiple submitters
- MAP3K8 p.Gly67Asp Uncertain significance Multiple submitters
- MAP3K8 p.Ile190Val Uncertain significance Multiple submitters
- MAP3K8 p.Met47Ile Uncertain significance Multiple submitters
- MAP3K8 p.Met49Lys Uncertain significance Multiple submitters
- MAP3K8 p.Ser5Ile Uncertain significance Multiple submitters
- MAP3K8 p.Thr429Pro Uncertain significance Multiple submitters
- MAP3K8 p.Trp199Arg Uncertain significance Multiple submitters
- MAP3K8 p.Trp199Cys Uncertain significance Multiple submitters
- MAP3K8 p.Ala148Thr Uncertain significance Single submitter
- MAP3K8 p.Ala196Thr Uncertain significance Single submitter
- MAP3K8 p.Ala196Val Uncertain significance Single submitter
- MAP3K8 p.Ala380Thr Uncertain significance Single submitter
- MAP3K8 p.Ala40Thr Uncertain significance Single submitter
- MAP3K8 p.Ala88Ser Uncertain significance Single submitter
- MAP3K8 p.Arg102Gly Uncertain significance Single submitter
- MAP3K8 p.Arg120Cys Uncertain significance Single submitter
- MAP3K8 p.Arg146Gln Uncertain significance Single submitter
- MAP3K8 p.Arg333His Uncertain significance Single submitter
- MAP3K8 p.Arg376His Uncertain significance Single submitter
- MAP3K8 p.Arg378Lys Uncertain significance Single submitter
- MAP3K8 p.Arg408Cys Uncertain significance Single submitter
- MAP3K8 p.Arg408His Uncertain significance Single submitter
- MAP3K8 p.Arg414Ser Uncertain significance Single submitter
- MAP3K8 p.Arg442Cys Uncertain significance Single submitter
- MAP3K8 p.Arg442His Uncertain significance Single submitter
- MAP3K8 p.Arg459Gln Uncertain significance Single submitter
- MAP3K8 p.Arg459Gly Uncertain significance Single submitter
- MAP3K8 p.Arg59His Uncertain significance Single submitter
- MAP3K8 p.Arg77Ile Uncertain significance Single submitter
- MAP3K8 p.Asn22His Uncertain significance Single submitter
- MAP3K8 p.Asn374Asp Uncertain significance Single submitter
- MAP3K8 p.Asn374Ser Uncertain significance Single submitter
- MAP3K8 p.Asn93Asp Uncertain significance Single submitter
- MAP3K8 p.Asp28Asn Uncertain significance Single submitter
- MAP3K8 p.Asp355Glu Uncertain significance Single submitter
- MAP3K8 p.Asp52Gly Uncertain significance Single submitter
- MAP3K8 p.Asp9Gly Uncertain significance Single submitter
- MAP3K8 p.Gln122His Uncertain significance Single submitter
- MAP3K8 p.Gln276Arg Uncertain significance Single submitter
- MAP3K8 p.Gln276Glu Uncertain significance Single submitter
- MAP3K8 p.Gln399Leu Uncertain significance Single submitter
- MAP3K8 p.Gln55Lys Uncertain significance Single submitter
- MAP3K8 p.Gln55Pro Uncertain significance Single submitter
- MAP3K8 p.Glu188Gln Uncertain significance Single submitter
- MAP3K8 p.Glu188Lys Uncertain significance Single submitter
- MAP3K8 p.Glu279Lys Uncertain significance Single submitter
- MAP3K8 p.Glu2Ala Uncertain significance Single submitter
- MAP3K8 p.Glu38Lys Uncertain significance Single submitter
- MAP3K8 p.Glu393Gln Uncertain significance Single submitter
- MAP3K8 p.Glu433Lys Uncertain significance Single submitter
- MAP3K8 p.Gly223Arg Uncertain significance Single submitter
- MAP3K8 p.Gly240Arg Uncertain significance Single submitter
- MAP3K8 p.Gly323Asp Uncertain significance Single submitter
- MAP3K8 p.Gly360Val Uncertain significance Single submitter
- MAP3K8 p.Gly453Ala Uncertain significance Single submitter
- MAP3K8 p.Gly7Glu Uncertain significance Single submitter
- MAP3K8 p.His90Arg Uncertain significance Single submitter
- MAP3K8 p.His90Tyr Uncertain significance Single submitter
- MAP3K8 p.Ile158Thr Uncertain significance Single submitter
- MAP3K8 p.Ile169Val Uncertain significance Single submitter
- MAP3K8 p.Ile27Val Uncertain significance Single submitter
- MAP3K8 p.Ile365Thr Uncertain significance Single submitter
- MAP3K8 p.Leu128Phe Uncertain significance Single submitter
- MAP3K8 p.Leu33His Uncertain significance Single submitter
- MAP3K8 p.Leu33Val Uncertain significance Single submitter
- MAP3K8 p.Leu364Val Uncertain significance Single submitter
- MAP3K8 p.Leu388Val Uncertain significance Single submitter
- MAP3K8 p.Leu417Gln Uncertain significance Single submitter
- MAP3K8 p.Leu444Phe Uncertain significance Single submitter
- MAP3K8 p.Lys285Glu Uncertain significance Single submitter
- MAP3K8 p.Lys329Glu Uncertain significance Single submitter
- MAP3K8 p.Lys409Glu Uncertain significance Single submitter
- MAP3K8 p.Lys61Arg Uncertain significance Single submitter
- MAP3K8 p.Met112Val Uncertain significance Single submitter
- MAP3K8 p.Met4Leu Uncertain significance Single submitter
- MAP3K8 p.Pro103Leu Uncertain significance Single submitter
-
MAP3K8 p.Pro116Thr
Uncertain significance
Single submitter
MAP3K8-related disorder
- MAP3K8 p.Pro377Ser Uncertain significance Single submitter
- MAP3K8 p.Pro390Leu Uncertain significance Single submitter
- MAP3K8 p.Pro420Ser Uncertain significance Single submitter
- MAP3K8 p.Pro44Leu Uncertain significance Single submitter
- MAP3K8 p.Ser177Cys Uncertain significance Single submitter
- MAP3K8 p.Ser24Phe Uncertain significance Single submitter
- MAP3K8 p.Ser358Arg Uncertain significance Single submitter
- MAP3K8 p.Ser413Gly Uncertain significance Single submitter
- MAP3K8 p.Ser5Arg Uncertain significance Single submitter
- MAP3K8 p.Ser60Thr Uncertain significance Single submitter
- MAP3K8 p.Ser66Gly Uncertain significance Single submitter
- MAP3K8 p.Thr115Ala Uncertain significance Single submitter
- MAP3K8 p.Thr463Met Uncertain significance Single submitter
- MAP3K8 p.Val275Ile Uncertain significance Single submitter
- MAP3K8 p.Val281Leu Uncertain significance Single submitter
-
MAP3K8 p.Met262Leu
Uncertain significance
No assertion criteria
MAP3K8-related disorder
Predictors split 24
The independent predictors disagree with each other — read with care.
- MAP3K8 p.Met277Ile Uncertain significance Multiple submitters
- MAP3K8 p.Ala165Val Uncertain significance Single submitter
- MAP3K8 p.Ala191Thr Uncertain significance Single submitter
- MAP3K8 p.Ala315Pro Uncertain significance Single submitter
- MAP3K8 p.Arg288Gln Uncertain significance Single submitter
- MAP3K8 p.Arg397Cys Uncertain significance Single submitter
- MAP3K8 p.Asp381Gly Uncertain significance Single submitter
- MAP3K8 p.Asp447Asn Conflicting Single submitter
- MAP3K8 p.Glu229Asp Uncertain significance Single submitter
- MAP3K8 p.Glu370Lys Uncertain significance Single submitter
- MAP3K8 p.Gly140Cys Uncertain significance Single submitter
- MAP3K8 p.Gly460Val Uncertain significance Single submitter
- MAP3K8 p.Leu405Pro Uncertain significance Single submitter
- MAP3K8 p.Lys265Glu Uncertain significance Single submitter
- MAP3K8 p.Met225Val Uncertain significance Single submitter
- MAP3K8 p.Met262Thr Uncertain significance Single submitter
- MAP3K8 p.Pro349Arg Uncertain significance Single submitter
- MAP3K8 p.Pro390Arg Uncertain significance Single submitter
- MAP3K8 p.Ser257Asn Uncertain significance Single submitter
- MAP3K8 p.Thr316Met Uncertain significance Single submitter
- MAP3K8 p.Thr322Ala Uncertain significance Single submitter
- MAP3K8 p.Thr322Met Uncertain significance Single submitter
- MAP3K8 p.Tyr341Cys Uncertain significance Single submitter
- MAP3K8 p.Val76Ala Uncertain significance Single submitter
All MAP3K8 variants
Conflicting classifications of pathogenicity 5
- p.Arg186Gln Single submitter ⚠
- p.Arg392Lys Single submitter ⚠
- p.Asn456Ser Single submitter ⚠
- p.Asp447Asn Single submitter ⚠
- p.Asp57Asn Single submitter ⚠
Benign 17
- c.1273+68T>C Multiple submitters
- c.1274-44G>T Multiple submitters
- c.336+261T>C Multiple submitters
- c.336+286C>T Multiple submitters
- c.336+47A>G Multiple submitters
- c.505-129A>G Multiple submitters
- c.874-189C>T Multiple submitters
- p.Leu448= Multiple submitters
- p.Ser305= Multiple submitters
- p.Ser53= Multiple submitters
- p.Tyr78= Multiple submitters
- c.1026+16C>T Single submitter
- c.1026+40_1026+41dup Single submitter
- c.1026+41dup Single submitter
- c.1273+170dup Single submitter
- c.336+19A>T Single submitter
- c.767-188G>A Single submitter
Benign/Likely benign 7
- c.1273+12C>T Multiple submitters
- p.Asp286= Multiple submitters
- p.Asp352= Multiple submitters
- p.Ile423= Multiple submitters
- p.Ser427Leu Multiple submitters
- p.Ser74= Multiple submitters
- p.Thr316= Multiple submitters
Likely benign 111
- c.505-10T>C Multiple submitters
- c.874-9C>G Multiple submitters
- p.Arg120= Multiple submitters
- p.Arg59Cys Multiple submitters
- p.Gln173= Multiple submitters
- p.Gly147= Multiple submitters
- p.Gly323= Multiple submitters
- p.Ile190= Multiple submitters
- p.Leu128= Multiple submitters
- p.Leu134= Multiple submitters
- p.Leu340= Multiple submitters
- p.Pro390= Multiple submitters
- p.Pro71= Multiple submitters
- p.Ser125= Multiple submitters
- c.1026+11T>A Single submitter
- c.1026+15A>G Single submitter
- c.1026+9G>T Single submitter
- c.1027-13G>A Single submitter
- c.1273+10C>T Single submitter
- c.1273+14G>A Single submitter
- c.1273+8C>T Single submitter
- c.1274-17A>T Single submitter
- c.1274-18T>C Single submitter
- c.1274-19G>T Single submitter
- c.1274-20T>C Single submitter
- c.336+14C>T Single submitter
- c.336+15G>A Single submitter
- c.336+15G>T Single submitter
- c.336+20G>A Single submitter
- c.336+20G>T Single submitter
- c.336+7T>G Single submitter
- c.337-6T>C Single submitter
- c.505-18T>C Single submitter
- c.505-6T>C Single submitter
- c.505-7G>A Single submitter
- c.766+20T>C Single submitter
- c.767-8C>A Single submitter
- c.873+14C>T Single submitter
- c.873+15A>G Single submitter
- c.873+9G>A Single submitter
- c.874-11T>A Single submitter
- c.874-14C>T Single submitter
- c.874-19T>C Single submitter
- c.874-20G>A Single submitter
- p.Ala148= Single submitter
- p.Ala155= Single submitter
- p.Ala165= Single submitter
- p.Ala191= Single submitter
- p.Ala308= Single submitter
- p.Ala315= Single submitter
- p.Ala379= Single submitter
- p.Arg392= Single submitter
- p.Arg408= Single submitter
- p.Asn118= Single submitter
- p.Asn422= Single submitter
- p.Asn56= Single submitter
- p.Asp126= Single submitter
- p.Asp157= Single submitter
- p.Gln117= Single submitter
- p.Gln122= Single submitter
- p.Glu211= Single submitter
- p.Glu220= Single submitter
- p.Glu31= Single submitter
- p.Glu366= Single submitter
- p.Glu370= Single submitter
- p.Glu433= Single submitter
- p.Glu58= Single submitter
- p.Gly195= Single submitter
- p.Gly223= Single submitter
- p.Gly303= Single submitter
- p.Gly314= Single submitter
- p.Gly449= Single submitter
- p.Ile139= Single submitter
- p.Ile14= Single submitter
- p.Ile169= Single submitter
- p.Ile259= Single submitter
- p.Ile446= Single submitter
- p.Leu205= Single submitter
- p.Leu219= Single submitter
- p.Leu244= Single submitter
- p.Leu317= Single submitter
- p.Leu438= Single submitter
- p.Leu46= Single submitter
- p.Leu63= Single submitter
- p.Lys11= Single submitter
- p.Lys175= Single submitter
- p.Pro116= Single submitter
- p.Pro170= Single submitter
- p.Pro326= Single submitter
- p.Pro373= Single submitter
- p.Pro39= Single submitter
- p.Ser274= Single submitter
- p.Ser295= Single submitter
- p.Ser400= Single submitter
- p.Ser427= Single submitter
- p.Ser431= Single submitter
- p.Ser45= Single submitter
- p.Thr160= Single submitter
- p.Thr278= Single submitter
- p.Thr322= Single submitter
- p.Thr432= Single submitter
- p.Thr463= Single submitter
- p.Thr80= Single submitter
- p.Tyr3= Single submitter
- p.Tyr454= Single submitter
- p.Val23= Single submitter
- p.Val269= Single submitter
- p.Val328Met Single submitter
- p.Val76= Single submitter
- p.Val81= Single submitter
- p.Arg302= No assertion criteria MAP3K8-related disorder
Uncertain significance 133
- p.Ala35Ser Multiple submitters ⚠
- p.Ala450Thr Multiple submitters
- p.Arg392Gly Multiple submitters ⚠
- p.Arg408Ser Multiple submitters ⚠
- p.Asn54Asp Multiple submitters ⚠
- p.Gly67Asp Multiple submitters ⚠
- p.Ile190Val Multiple submitters ⚠
- p.Met277Ile Multiple submitters ⚠
- p.Met47Ile Multiple submitters ⚠
- p.Met49Lys Multiple submitters ⚠
- p.Ser5Ile Multiple submitters ⚠
- p.Thr429Pro Multiple submitters ⚠
- p.Trp199Arg Multiple submitters ⚠
- p.Trp199Cys Multiple submitters ⚠
- c.336+4C>T Single submitter
- c.336+5G>A Single submitter
- c.504+6T>C Single submitter
- c.766+6T>C Single submitter
- p.Ala148Thr Single submitter ⚠
- p.Ala165Val Single submitter ⚠
- p.Ala191Thr Single submitter ⚠
- p.Ala196Thr Single submitter ⚠
- p.Ala196Val Single submitter ⚠
- p.Ala315Pro Single submitter ⚠
- p.Ala380Thr Single submitter ⚠
- p.Ala40Thr Single submitter ⚠
- p.Ala88Ser Single submitter ⚠
- p.Arg102Gly Single submitter ⚠
- p.Arg120Cys Single submitter ⚠
- p.Arg146Gln Single submitter ⚠
- p.Arg288Gln Single submitter ⚠
- p.Arg333His Single submitter ⚠
- p.Arg376His Single submitter ⚠
- p.Arg378Lys Single submitter ⚠
- p.Arg397Cys Single submitter ⚠
- p.Arg408Cys Single submitter ⚠
- p.Arg408His Single submitter ⚠
- p.Arg414Ser Single submitter ⚠
- p.Arg442Cys Single submitter ⚠
- p.Arg442His Single submitter ⚠
- p.Arg459Gln Single submitter ⚠
- p.Arg459Gly Single submitter ⚠
- p.Arg59His Single submitter ⚠
- p.Arg77Ile Single submitter ⚠
- p.Asn22His Single submitter ⚠
- p.Asn374Asp Single submitter ⚠
- p.Asn374Ser Single submitter ⚠
- p.Asn93Asp Single submitter ⚠
- p.Asp28Asn Single submitter ⚠
- p.Asp355Glu Single submitter ⚠
- p.Asp381Gly Single submitter ⚠
- p.Asp52Gly Single submitter ⚠
- p.Asp9Gly Single submitter ⚠
- p.Gln122His Single submitter ⚠
- p.Gln276Arg Single submitter ⚠
- p.Gln276Glu Single submitter ⚠
- p.Gln399Leu Single submitter ⚠
- p.Gln55Lys Single submitter ⚠
- p.Gln55Pro Single submitter ⚠
- p.Glu188Gln Single submitter ⚠
- p.Glu188Lys Single submitter ⚠
- p.Glu229Asp Single submitter ⚠
- p.Glu279Lys Single submitter ⚠
- p.Glu2Ala Single submitter ⚠
- p.Glu370Lys Single submitter ⚠
- p.Glu38Lys Single submitter ⚠
- p.Glu393Gln Single submitter ⚠
- p.Glu433Lys Single submitter ⚠
- p.Glu465= Single submitter
- p.Gly140Cys Single submitter ⚠
- p.Gly210= Single submitter
- p.Gly223Arg Single submitter ⚠
- p.Gly240Arg Single submitter ⚠
- p.Gly323Asp Single submitter ⚠
- p.Gly360Val Single submitter ⚠
- p.Gly453Ala Single submitter ⚠
- p.Gly460Val Single submitter ⚠
- p.Gly7Glu Single submitter ⚠
- p.His90Arg Single submitter ⚠
- p.His90Tyr Single submitter ⚠
- p.Ile158Thr Single submitter ⚠
- p.Ile169Val Single submitter ⚠
- p.Ile27Val Single submitter ⚠
- p.Ile365Thr Single submitter ⚠
- p.Leu128Phe Single submitter ⚠
- p.Leu33His Single submitter ⚠
- p.Leu33Val Single submitter ⚠
- p.Leu364Val Single submitter ⚠
- p.Leu388Val Single submitter ⚠
- p.Leu405Pro Single submitter ⚠
- p.Leu417Gln Single submitter ⚠
- p.Leu444Phe Single submitter ⚠
- p.Lys265Glu Single submitter ⚠
- p.Lys285Glu Single submitter ⚠
- p.Lys329Glu Single submitter ⚠
- p.Lys409Glu Single submitter ⚠
- p.Lys61Arg Single submitter ⚠
- p.Met112Val Single submitter ⚠
- p.Met225Val Single submitter ⚠
- p.Met262Thr Single submitter ⚠
- p.Met4Leu Single submitter ⚠
- p.Pro103Leu Single submitter ⚠
- p.Pro116Thr Single submitter MAP3K8-related disorder ⚠
- p.Pro349Arg Single submitter ⚠
- p.Pro373Ala Single submitter
- p.Pro377Ser Single submitter ⚠
- p.Pro390Arg Single submitter ⚠
- p.Pro390Leu Single submitter ⚠
- p.Pro420Ser Single submitter ⚠
- p.Pro44Leu Single submitter ⚠
- p.Pro461Gln Single submitter
- p.Ser177Cys Single submitter ⚠
- p.Ser24Phe Single submitter ⚠
- p.Ser257Asn Single submitter ⚠
- p.Ser358Arg Single submitter ⚠
- p.Ser413Gly Single submitter ⚠
- p.Ser5Arg Single submitter ⚠
- p.Ser60Thr Single submitter ⚠
- p.Ser66Gly Single submitter ⚠
- p.Ter468Arg Single submitter
- p.Thr115Ala Single submitter ⚠
- p.Thr160Met Single submitter
- p.Thr316Ala Single submitter
- p.Thr316Met Single submitter ⚠
- p.Thr322Ala Single submitter ⚠
- p.Thr322Met Single submitter ⚠
- p.Thr463Met Single submitter ⚠
- p.Tyr341Cys Single submitter ⚠
- p.Tyr78Ter Single submitter
- p.Val275Ile Single submitter ⚠
- p.Val281Leu Single submitter ⚠
- p.Val76Ala Single submitter ⚠
- p.Met262Leu No assertion criteria MAP3K8-related disorder ⚠