MAP3K9 — 159 ClinVar variants

All ClinVar germline MAP3K9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 145 flagged for review →

4 Likely benign · 155 Uncertain significance

Full MAP3K9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 145

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 119

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 26

The independent predictors disagree with each other — read with care.

All MAP3K9 variants

Likely benign 4

p.Gln98= Single submitter
p.His175= Single submitter
p.Pro177= Single submitter
p.Thr373= Single submitter

Uncertain significance 155

c.2027-415G>T Single submitter
p.Ala1086Ser Single submitter ⚠
p.Ala116Gly Single submitter ⚠
p.Ala246Thr Single submitter ⚠
p.Ala309Val Single submitter
p.Ala379Thr Single submitter ⚠
p.Ala65Ser Single submitter ⚠
p.Ala787Val Single submitter ⚠
p.Ala928Ser Single submitter ⚠
p.Arg1001Gln Single submitter ⚠
p.Arg1001Trp Single submitter ⚠
p.Arg1003Trp Single submitter ⚠
p.Arg1046Gln Single submitter ⚠
p.Arg120His Single submitter ⚠
p.Arg174Cys Single submitter ⚠
p.Arg189His Single submitter ⚠
p.Arg224His Single submitter ⚠
p.Arg224Pro Single submitter ⚠
p.Arg236Ser Single submitter ⚠
p.Arg267Cys Single submitter ⚠
p.Arg438Thr Single submitter ⚠
p.Arg482Gln Single submitter ⚠
p.Arg482Trp Single submitter ⚠
p.Arg497Gly Single submitter ⚠
p.Arg497Trp Single submitter ⚠
p.Arg546His Single submitter ⚠
p.Arg620Cys Single submitter ⚠
p.Arg620His Single submitter ⚠
p.Arg689His Single submitter ⚠
p.Arg705His Single submitter ⚠
p.Arg747His Single submitter ⚠
p.Arg748His Single submitter ⚠
p.Arg788Gln Single submitter ⚠
p.Arg794Gln Single submitter ⚠
p.Arg794Trp Single submitter ⚠
p.Arg806Trp Single submitter
p.Arg847Cys Single submitter
p.Arg851His Single submitter ⚠
p.Arg887Cys Single submitter ⚠
p.Arg887Ser Single submitter ⚠
p.Arg890Gly Single submitter ⚠
p.Arg913Trp Single submitter ⚠
p.Arg914Trp Single submitter ⚠
p.Arg974Cys Single submitter ⚠
p.Arg974His Single submitter ⚠
p.Arg974Leu Single submitter
p.Arg996Cys Single submitter ⚠
p.Asn1022Asp Single submitter ⚠
p.Asn215Ser Single submitter ⚠
p.Asn655Ile Single submitter ⚠
p.Asn655Ser Single submitter ⚠
p.Asn882Ser Single submitter ⚠
p.Asp176His Single submitter ⚠
p.Asp258His Single submitter ⚠
p.Asp258Val Single submitter ⚠
p.Asp389Asn Single submitter ⚠
p.Cys875Arg Single submitter ⚠
p.Gln458Arg Single submitter ⚠
p.Gln606Glu Single submitter ⚠
p.Glu126Gly Single submitter ⚠
p.Glu143Ala Single submitter ⚠
p.Glu33Val Single submitter ⚠
p.Glu36Ala Single submitter ⚠
p.Glu47Lys Single submitter ⚠
p.Glu481Lys Single submitter ⚠
p.Glu583Lys Single submitter ⚠
p.Glu585Val Single submitter ⚠
p.Glu687Gln Single submitter ⚠
p.Glu719Gln Single submitter ⚠
p.Glu750Lys Single submitter ⚠
p.Glu924Gln Single submitter ⚠
p.Glu990Asp Single submitter ⚠
p.Gly124Ser Single submitter ⚠
p.Gly605Ser Single submitter ⚠
p.Gly615Arg Single submitter ⚠
p.Gly668Arg Single submitter
p.Gly684Glu Single submitter ⚠
p.Gly742Ser Single submitter ⚠
p.Gly755Ser Single submitter ⚠
p.Gly90Asp Single submitter ⚠
p.Gly936Glu Single submitter ⚠
p.Gly944Glu Single submitter ⚠
p.His175Arg Single submitter ⚠
p.His175Gln Single submitter ⚠
p.Ile149Phe Single submitter ⚠
p.Ile181Val Single submitter ⚠
p.Ile249Thr Single submitter ⚠
p.Ile487Val Single submitter ⚠
p.Ile562Val Single submitter ⚠
p.Ile717Asn Single submitter ⚠
p.Leu137Ser Single submitter ⚠
p.Leu456Val Single submitter ⚠
p.Leu639Phe Single submitter ⚠
p.Leu753Val Single submitter ⚠
p.Leu815Pro Single submitter ⚠
p.Leu834Pro Single submitter ⚠
p.Leu903Phe Single submitter ⚠
p.Lys640Arg Single submitter ⚠
p.Lys774Arg Single submitter ⚠
p.Met325Thr Single submitter ⚠
p.Met414Ile Single submitter ⚠
p.Met536Thr Single submitter ⚠
p.Met862Arg Single submitter ⚠
p.Met945Val Single submitter ⚠
p.Phe1055Leu Single submitter ⚠
p.Pro1020Leu Single submitter ⚠
p.Pro1047Arg Single submitter ⚠
p.Pro1050Leu Single submitter ⚠
p.Pro1059Leu Single submitter ⚠
p.Pro1059Ser Single submitter ⚠
p.Pro1082Leu Single submitter ⚠
p.Pro123Ala Single submitter ⚠
p.Pro128Ser Single submitter ⚠
p.Pro201Ala Single submitter ⚠
p.Pro371Ala Single submitter ⚠
p.Pro45Arg Single submitter ⚠
p.Pro534Leu Single submitter ⚠
p.Pro550Ser Single submitter ⚠
p.Pro580Arg Single submitter ⚠
p.Pro580Leu Single submitter ⚠
p.Pro704Leu Single submitter ⚠
p.Pro783Ser Single submitter ⚠
p.Pro811Arg Single submitter ⚠
p.Pro811Gln Single submitter
p.Pro828Ser Single submitter ⚠
p.Pro871Ser Single submitter ⚠
p.Pro941Ser Single submitter ⚠
p.Pro949Arg Single submitter ⚠
p.Pro951Thr Single submitter ⚠
p.Pro969His Single submitter ⚠
p.Pro970Gln Single submitter
p.Pro970Thr Single submitter
p.Ser1023Cys Single submitter ⚠
p.Ser1023Thr Single submitter ⚠
p.Ser272Arg Single submitter ⚠
p.Ser308Thr Single submitter ⚠
p.Ser547Cys Single submitter ⚠
p.Ser693Leu Single submitter ⚠
p.Ser713Phe Single submitter ⚠
p.Ser738Asn Single submitter ⚠
p.Ser854Arg Single submitter ⚠
p.Ser865Arg Single submitter
p.Ser907Leu Single submitter ⚠
p.Ser952Asn Single submitter ⚠
p.Thr1028Met Single submitter ⚠
p.Thr373Met Single submitter ⚠
p.Thr728Met Single submitter ⚠
p.Thr734Met Single submitter ⚠
p.Trp95Cys Single submitter ⚠
p.Val103Met Single submitter ⚠
p.Val1081Leu Single submitter ⚠
p.Val1081Met Single submitter ⚠
p.Val209Leu Single submitter ⚠
p.Val247Met Single submitter ⚠
p.Val643Glu Single submitter ⚠