MAP4 — 219 ClinVar variants
All ClinVar germline MAP4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 172 flagged for review →
12 Benign · 34 Likely benign · 173 Uncertain significance
Full MAP4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 172
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 144
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MAP4 p.Ala150Ser Uncertain significance Single submitter
- MAP4 p.Ala1922Val Uncertain significance Single submitter
- MAP4 p.Ala1926Pro Uncertain significance Single submitter
- MAP4 p.Ala1941Thr Uncertain significance Single submitter
- MAP4 p.Ala1959Gly Uncertain significance Single submitter
- MAP4 p.Ala1962Asp Uncertain significance Single submitter
- MAP4 p.Ala1962Pro Uncertain significance Single submitter
- MAP4 p.Ala2026Val Uncertain significance Single submitter
- MAP4 p.Ala2056Ser Uncertain significance Single submitter
- MAP4 p.Ala2074Thr Uncertain significance Single submitter
- MAP4 p.Ala2127Gly Uncertain significance Single submitter
- MAP4 p.Ala2134Val Uncertain significance Single submitter
- MAP4 p.Ala2248Asp Uncertain significance Single submitter
- MAP4 p.Ala2258Val Uncertain significance Single submitter
- MAP4 p.Ala2263Ser Uncertain significance Single submitter
- MAP4 p.Ala2267Val Uncertain significance Single submitter
- MAP4 p.Ala259Thr Uncertain significance Single submitter
- MAP4 p.Ala259Val Uncertain significance Single submitter
- MAP4 p.Ala301Thr Uncertain significance Single submitter
- MAP4 p.Ala331Ser Uncertain significance Single submitter
- MAP4 p.Ala331Thr Uncertain significance Single submitter
- MAP4 p.Ala551Asp Uncertain significance Single submitter
- MAP4 p.Ala7Gly Uncertain significance Single submitter
- MAP4 p.Arg1900His Uncertain significance Single submitter
- MAP4 p.Arg1930Gln Uncertain significance Single submitter
- MAP4 p.Arg1969Gly Uncertain significance Single submitter
- MAP4 p.Arg2005His Uncertain significance Single submitter
- MAP4 p.Arg2042Pro Uncertain significance Single submitter
- MAP4 p.Arg2067Cys Uncertain significance Single submitter
- MAP4 p.Arg2081Cys Uncertain significance Single submitter
- MAP4 p.Arg2112Gln Uncertain significance Single submitter
- MAP4 p.Arg2112Pro Uncertain significance Single submitter
- MAP4 p.Asn2071Ser Uncertain significance Single submitter
- MAP4 p.Asn2079Lys Uncertain significance Single submitter
-
MAP4 p.Asn457Ser
Uncertain significance
Single submitter
Kleine-Levin syndrome
- MAP4 p.Asn86Tyr Uncertain significance Single submitter
- MAP4 p.Asp161Tyr Uncertain significance Single submitter
- MAP4 p.Asp2002Asn Uncertain significance Single submitter
- MAP4 p.Asp285Asn Uncertain significance Single submitter
- MAP4 p.Asp327Gly Uncertain significance Single submitter
- MAP4 p.Asp327Val Uncertain significance Single submitter
- MAP4 p.Asp423Asn Uncertain significance Single submitter
- MAP4 p.Asp491Asn Uncertain significance Single submitter
- MAP4 p.Asp491Val Uncertain significance Single submitter
- MAP4 p.Asp591Gly Uncertain significance Single submitter
- MAP4 p.Asp612Ala Uncertain significance Single submitter
- MAP4 p.Cys67Ser Uncertain significance Single submitter
- MAP4 p.Gln598Pro Uncertain significance Single submitter
- MAP4 p.Glu105Gly Uncertain significance Single submitter
- MAP4 p.Glu105Lys Uncertain significance Single submitter
- MAP4 p.Glu2239Lys Uncertain significance Single submitter
- MAP4 p.Glu271Lys Uncertain significance Single submitter
- MAP4 p.Glu311Lys Uncertain significance Single submitter
- MAP4 p.Glu608Asp Uncertain significance Single submitter
- MAP4 p.Glu640Gly Uncertain significance Single submitter
- MAP4 p.Glu640Lys Uncertain significance Single submitter
- MAP4 p.Glu641Gly Uncertain significance Single submitter
- MAP4 p.Gly1819Glu Uncertain significance Single submitter
- MAP4 p.Gly1825Ala Uncertain significance Single submitter
- MAP4 p.Gly1891Ala Uncertain significance Single submitter
- MAP4 p.Gly1986Ala Uncertain significance Single submitter
- MAP4 p.Gly2022Glu Uncertain significance Single submitter
- MAP4 p.Gly2028Arg Uncertain significance Single submitter
- MAP4 p.Gly2166Arg Uncertain significance Single submitter
- MAP4 p.Gly2166Val Uncertain significance Single submitter
- MAP4 p.Gly2236Arg Uncertain significance Single submitter
- MAP4 p.Gly630Glu Uncertain significance Single submitter
- MAP4 p.His2273Asn Uncertain significance Single submitter
- MAP4 p.Ile164Val Uncertain significance Single submitter
- MAP4 p.Ile1813Lys Uncertain significance Single submitter
- MAP4 p.Ile1921Thr Uncertain significance Single submitter
- MAP4 p.Ile2049Leu Uncertain significance Single submitter
- MAP4 p.Ile2126Thr Uncertain significance Single submitter
- MAP4 p.Ile2159Thr Uncertain significance Single submitter
- MAP4 p.Ile360Val Uncertain significance Single submitter
- MAP4 p.Ile386Thr Uncertain significance Single submitter
- MAP4 p.Ile531Val Uncertain significance Single submitter
- MAP4 p.Ile73Met Uncertain significance Single submitter
- MAP4 p.Leu195Ile Uncertain significance Single submitter
- MAP4 p.Leu2242Val Uncertain significance Single submitter
- MAP4 p.Leu274Val Uncertain significance Single submitter
- MAP4 p.Leu284Phe Uncertain significance Single submitter
- MAP4 p.Lys1863Thr Uncertain significance Single submitter
- MAP4 p.Lys2104Thr Uncertain significance Single submitter
- MAP4 p.Lys2113Asn Uncertain significance Single submitter
- MAP4 p.Lys2200Arg Uncertain significance Single submitter
- MAP4 p.Lys634Met Uncertain significance Single submitter
- MAP4 p.Lys652Asn Uncertain significance Single submitter
- MAP4 p.Met143Leu Uncertain significance Single submitter
- MAP4 p.Met242Ile Uncertain significance Single submitter
- MAP4 p.Met258Ile Uncertain significance Single submitter
- MAP4 p.Met278Thr Uncertain significance Single submitter
- MAP4 p.Met540Ile Uncertain significance Single submitter
- MAP4 p.Phe103Ser Uncertain significance Single submitter
- MAP4 p.Pro140Thr Uncertain significance Single submitter
- MAP4 p.Pro180Ala Uncertain significance Single submitter
- MAP4 p.Pro1894Arg Uncertain significance Single submitter
- MAP4 p.Pro1894Gln Uncertain significance Single submitter
- MAP4 p.Pro1976Leu Uncertain significance Single submitter
- MAP4 p.Pro198Leu Uncertain significance Single submitter
- MAP4 p.Pro2063Thr Uncertain significance Single submitter
- MAP4 p.Pro2125Leu Uncertain significance Single submitter
- MAP4 p.Pro212Thr Uncertain significance Single submitter
- MAP4 p.Pro2133Ser Uncertain significance Single submitter
- MAP4 p.Pro2241Ser Uncertain significance Single submitter
- MAP4 p.Pro2246Ala Uncertain significance Single submitter
- MAP4 p.Pro2274Ser Uncertain significance Single submitter
- MAP4 p.Pro235Leu Uncertain significance Single submitter
- MAP4 p.Pro252Ser Uncertain significance Single submitter
- MAP4 p.Pro454Leu Uncertain significance Single submitter
- MAP4 p.Pro482Ser Uncertain significance Single submitter
- MAP4 p.Pro550Leu Uncertain significance Single submitter
- MAP4 p.Pro577Leu Uncertain significance Single submitter
- MAP4 p.Pro619Ser Uncertain significance Single submitter
- MAP4 p.Ser175Ile Uncertain significance Single submitter
- MAP4 p.Ser1890Leu Uncertain significance Single submitter
- MAP4 p.Ser2021Ile Uncertain significance Single submitter
- MAP4 p.Ser2055Leu Uncertain significance Single submitter
- MAP4 p.Ser2238Ile Uncertain significance Single submitter
- MAP4 p.Ser329Phe Uncertain significance Single submitter
- MAP4 p.Ser656Gly Uncertain significance Single submitter
- MAP4 p.Thr101Ala Uncertain significance Single submitter
- MAP4 p.Thr101Ile Uncertain significance Single submitter
- MAP4 p.Thr101Ser Uncertain significance Single submitter
- MAP4 p.Thr123Ile Uncertain significance Single submitter
- MAP4 p.Thr1951Pro Uncertain significance Single submitter
- MAP4 p.Thr2045Ala Uncertain significance Single submitter
- MAP4 p.Thr2046Ala Uncertain significance Single submitter
- MAP4 p.Thr2062Ile Uncertain significance Single submitter
- MAP4 p.Thr2070Ile Uncertain significance Single submitter
- MAP4 p.Thr2110Ala Uncertain significance Single submitter
- MAP4 p.Thr248Ile Uncertain significance Single submitter
- MAP4 p.Thr248Ser Uncertain significance Single submitter
- MAP4 p.Thr484Ile Uncertain significance Single submitter
- MAP4 p.Thr526Arg Uncertain significance Single submitter
- MAP4 p.Thr631Arg Uncertain significance Single submitter
- MAP4 p.Val1952Ile Uncertain significance Single submitter
- MAP4 p.Val1999Ile Uncertain significance Single submitter
- MAP4 p.Val2029Met Uncertain significance Single submitter
- MAP4 p.Val2140Ile Uncertain significance Single submitter
- MAP4 p.Val2162Ile Uncertain significance Single submitter
- MAP4 p.Val534Ile Uncertain significance Single submitter
- MAP4 p.Val628Ala Uncertain significance Single submitter
- MAP4 p.Ala391Thr Uncertain significance No assertion criteria
Predictors split 28
The independent predictors disagree with each other — read with care.
- MAP4 p.Ala2134Glu Uncertain significance Single submitter
- MAP4 p.Ala365Ser Uncertain significance Single submitter
- MAP4 p.Arg2064Trp Uncertain significance Single submitter
- MAP4 p.Arg2098Trp Uncertain significance Single submitter
- MAP4 p.Arg356Lys Uncertain significance Single submitter
- MAP4 p.Asp2220Asn Uncertain significance Single submitter
- MAP4 p.Asp347Tyr Uncertain significance Single submitter
- MAP4 p.Asp395Ala Uncertain significance Single submitter
- MAP4 p.Glu379Gln Uncertain significance Single submitter
- MAP4 p.Ile21Lys Uncertain significance Single submitter
- MAP4 p.Leu2077Val Uncertain significance Single submitter
- MAP4 p.Leu350Val Uncertain significance Single submitter
- MAP4 p.Lys1977Asn Uncertain significance Single submitter
- MAP4 p.Lys2143Asn Uncertain significance Single submitter
- MAP4 p.Lys2156Arg Uncertain significance Single submitter
- MAP4 p.Lys2160Arg Uncertain significance Single submitter
- MAP4 p.Lys394Asn Uncertain significance Single submitter
- MAP4 p.Lys400Glu Uncertain significance Single submitter
- MAP4 p.Pro2063Arg Uncertain significance Single submitter
- MAP4 p.Pro2063His Uncertain significance Single submitter
- MAP4 p.Pro309His Uncertain significance Single submitter
- MAP4 p.Ser2145Arg Uncertain significance Single submitter
- MAP4 p.Ser2151Ala Uncertain significance Single submitter
- MAP4 p.Thr2087Met Uncertain significance Single submitter
- MAP4 p.Thr45Lys Uncertain significance Single submitter
- MAP4 p.Val37Asp Uncertain significance Single submitter
-
MAP4 p.Arg23Trp
Likely benign
No assertion criteria
MAP4-related disorder
-
MAP4 p.Ser427Tyr
Benign
No assertion criteria
MAP4-related disorder
All MAP4 variants
Benign 12
- c.292+9T>G Multiple submitters
- p.Gln1950= Multiple submitters
- p.Val37= Multiple submitters
- p.Arg23Gln No assertion criteria MAP4-related disorder
- p.Glu441Gln No assertion criteria MAP4-related disorder
- p.Ile386Val No assertion criteria MAP4-related disorder
- p.Pro135Ser No assertion criteria MAP4-related disorder
- p.Ser427Tyr No assertion criteria MAP4-related disorder ⚠
- p.Thr216Met No assertion criteria MAP4-related disorder
- p.Val133= No assertion criteria MAP4-related disorder
- p.Val1822= No assertion criteria MAP4-related disorder
- p.Val628Ile No assertion criteria MAP4-related disorder
Likely benign 34
- p.Leu516= Multiple submitters
- c.*138A>G Single submitter
- c.*69G>A Single submitter
- p.Ala1926Val Single submitter
- p.Asp134Asn Single submitter
- p.Gly19Glu Single submitter
- p.Ile425Val Single submitter
- p.Ile459Val Single submitter
- p.Met2014Val Single submitter
- p.Pro2252Leu Single submitter
- p.Pro488Leu Single submitter
- p.Pro494Leu Single submitter
- p.Ser2141Phe Single submitter
- p.Thr1955Ala Single submitter
- p.Thr248Ala Single submitter
- p.Thr631Met Single submitter
- c.292+2409G>A No assertion criteria MAP4-related disorder
- c.*100G>A No assertion criteria MAP4-related disorder
- c.*44G>A No assertion criteria MAP4-related disorder
- p.Ala2123= No assertion criteria MAP4-related disorder
- p.Ala2134= No assertion criteria MAP4-related disorder
- p.Ala437= No assertion criteria MAP4-related disorder
- p.Arg23Trp No assertion criteria MAP4-related disorder ⚠
- p.Asn569= No assertion criteria MAP4-related disorder
- p.Asp16= No assertion criteria MAP4-related disorder
- p.Glu20= No assertion criteria MAP4-related disorder
- p.Leu2242= No assertion criteria MAP4-related disorder
- p.Pro100= No assertion criteria MAP4-related disorder
- p.Pro1920= No assertion criteria MAP4-related disorder
- p.Pro2264= No assertion criteria MAP4-related disorder
- p.Ser2128= No assertion criteria MAP4-related disorder
- p.Val549= No assertion criteria MAP4-related disorder
- p.Val613Met No assertion criteria MAP4-related disorder
- p.Val628= No assertion criteria MAP4-related disorder
Uncertain significance 173
- p.Ala150Ser Single submitter ⚠
- p.Ala1922Val Single submitter ⚠
- p.Ala1926Pro Single submitter ⚠
- p.Ala1941Thr Single submitter ⚠
- p.Ala1959Gly Single submitter ⚠
- p.Ala1962Asp Single submitter ⚠
- p.Ala1962Pro Single submitter ⚠
- p.Ala2026Val Single submitter ⚠
- p.Ala2056Ser Single submitter ⚠
- p.Ala2074Thr Single submitter ⚠
- p.Ala2127Gly Single submitter ⚠
- p.Ala2134Glu Single submitter ⚠
- p.Ala2134Val Single submitter ⚠
- p.Ala2188Val Single submitter
- p.Ala2248Asp Single submitter ⚠
- p.Ala2258Val Single submitter ⚠
- p.Ala2263Ser Single submitter ⚠
- p.Ala2267Val Single submitter ⚠
- p.Ala259Thr Single submitter ⚠
- p.Ala259Val Single submitter ⚠
- p.Ala301Thr Single submitter ⚠
- p.Ala331Ser Single submitter ⚠
- p.Ala331Thr Single submitter ⚠
- p.Ala365Ser Single submitter ⚠
- p.Ala551Asp Single submitter ⚠
- p.Ala7Gly Single submitter ⚠
- p.Arg1900His Single submitter ⚠
- p.Arg1930Gln Single submitter ⚠
- p.Arg1969Gly Single submitter ⚠
- p.Arg2005His Single submitter ⚠
- p.Arg2042Pro Single submitter ⚠
- p.Arg2064Trp Single submitter ⚠
- p.Arg2067Cys Single submitter ⚠
- p.Arg2081Cys Single submitter ⚠
- p.Arg2098Trp Single submitter ⚠
- p.Arg2112Gln Single submitter ⚠
- p.Arg2112Pro Single submitter ⚠
- p.Arg356Lys Single submitter ⚠
- p.Asn2071Ser Single submitter ⚠
- p.Asn2079Lys Single submitter ⚠
- p.Asn457Ser Single submitter Kleine-Levin syndrome ⚠
- p.Asn86Tyr Single submitter ⚠
- p.Asp161Tyr Single submitter ⚠
- p.Asp2002Asn Single submitter ⚠
- p.Asp2220Asn Single submitter ⚠
- p.Asp285Asn Single submitter ⚠
- p.Asp327Gly Single submitter ⚠
- p.Asp327Val Single submitter ⚠
- p.Asp347Tyr Single submitter ⚠
- p.Asp395Ala Single submitter ⚠
- p.Asp423Asn Single submitter ⚠
- p.Asp491Asn Single submitter ⚠
- p.Asp491Val Single submitter ⚠
- p.Asp591Gly Single submitter ⚠
- p.Asp612Ala Single submitter ⚠
- p.Cys67Ser Single submitter ⚠
- p.Gln598Pro Single submitter ⚠
- p.Glu105Gly Single submitter ⚠
- p.Glu105Lys Single submitter ⚠
- p.Glu1990Gln Single submitter
- p.Glu2239Lys Single submitter ⚠
- p.Glu271Lys Single submitter ⚠
- p.Glu311Lys Single submitter ⚠
- p.Glu379Gln Single submitter ⚠
- p.Glu608Asp Single submitter ⚠
- p.Glu640Gly Single submitter ⚠
- p.Glu640Lys Single submitter ⚠
- p.Glu641Gly Single submitter ⚠
- p.Gly1819Glu Single submitter ⚠
- p.Gly1825Ala Single submitter ⚠
- p.Gly1891Ala Single submitter ⚠
- p.Gly1986Ala Single submitter ⚠
- p.Gly2022Glu Single submitter ⚠
- p.Gly2028Arg Single submitter ⚠
- p.Gly2166Arg Single submitter ⚠
- p.Gly2166Val Single submitter ⚠
- p.Gly2236Arg Single submitter ⚠
- p.Gly630Glu Single submitter ⚠
- p.His2273Asn Single submitter ⚠
- p.Ile164Val Single submitter ⚠
- p.Ile1813Lys Single submitter ⚠
- p.Ile1921Thr Single submitter ⚠
- p.Ile2049Leu Single submitter ⚠
- p.Ile2126Thr Single submitter ⚠
- p.Ile2159Thr Single submitter ⚠
- p.Ile21Lys Single submitter ⚠
- p.Ile360Val Single submitter ⚠
- p.Ile386Thr Single submitter ⚠
- p.Ile531Val Single submitter ⚠
- p.Ile73Met Single submitter ⚠
- p.Leu195Ile Single submitter ⚠
- p.Leu2077Val Single submitter ⚠
- p.Leu2242Val Single submitter ⚠
- p.Leu274Val Single submitter ⚠
- p.Leu284Phe Single submitter ⚠
- p.Leu350Val Single submitter ⚠
- p.Lys1863Thr Single submitter ⚠
- p.Lys1977Asn Single submitter ⚠
- p.Lys2104Thr Single submitter ⚠
- p.Lys2113Asn Single submitter ⚠
- p.Lys2143Asn Single submitter ⚠
- p.Lys2156Arg Single submitter ⚠
- p.Lys2160Arg Single submitter ⚠
- p.Lys2200Arg Single submitter ⚠
- p.Lys394Asn Single submitter ⚠
- p.Lys400Glu Single submitter ⚠
- p.Lys634Met Single submitter ⚠
- p.Lys652Asn Single submitter ⚠
- p.Met143Leu Single submitter ⚠
- p.Met242Ile Single submitter ⚠
- p.Met258Ile Single submitter ⚠
- p.Met278Thr Single submitter ⚠
- p.Met540Ile Single submitter ⚠
- p.Phe103Ser Single submitter ⚠
- p.Pro140Thr Single submitter ⚠
- p.Pro180Ala Single submitter ⚠
- p.Pro1894Arg Single submitter ⚠
- p.Pro1894Gln Single submitter ⚠
- p.Pro1976Leu Single submitter ⚠
- p.Pro198Leu Single submitter ⚠
- p.Pro2063Arg Single submitter ⚠
- p.Pro2063His Single submitter ⚠
- p.Pro2063Thr Single submitter ⚠
- p.Pro2125Leu Single submitter ⚠
- p.Pro212Thr Single submitter ⚠
- p.Pro2133Ser Single submitter ⚠
- p.Pro2241Ser Single submitter ⚠
- p.Pro2246Ala Single submitter ⚠
- p.Pro2274Ser Single submitter ⚠
- p.Pro235Leu Single submitter ⚠
- p.Pro252Ser Single submitter ⚠
- p.Pro309His Single submitter ⚠
- p.Pro454Leu Single submitter ⚠
- p.Pro482Ser Single submitter ⚠
- p.Pro550Leu Single submitter ⚠
- p.Pro577Leu Single submitter ⚠
- p.Pro619Ser Single submitter ⚠
- p.Ser175Ile Single submitter ⚠
- p.Ser1890Leu Single submitter ⚠
- p.Ser2021Ile Single submitter ⚠
- p.Ser2055Leu Single submitter ⚠
- p.Ser2145Arg Single submitter ⚠
- p.Ser2151Ala Single submitter ⚠
- p.Ser2238Ile Single submitter ⚠
- p.Ser329Phe Single submitter ⚠
- p.Ser656Gly Single submitter ⚠
- p.Thr101Ala Single submitter ⚠
- p.Thr101Ile Single submitter ⚠
- p.Thr101Ser Single submitter ⚠
- p.Thr123Ile Single submitter ⚠
- p.Thr1951Pro Single submitter ⚠
- p.Thr2045Ala Single submitter ⚠
- p.Thr2046Ala Single submitter ⚠
- p.Thr2062Ile Single submitter ⚠
- p.Thr2070Ile Single submitter ⚠
- p.Thr2087Met Single submitter ⚠
- p.Thr2110Ala Single submitter ⚠
- p.Thr248Ile Single submitter ⚠
- p.Thr248Ser Single submitter ⚠
- p.Thr45Lys Single submitter ⚠
- p.Thr484Ile Single submitter ⚠
- p.Thr526Arg Single submitter ⚠
- p.Thr631Arg Single submitter ⚠
- p.Val1952Ile Single submitter ⚠
- p.Val1999Ile Single submitter ⚠
- p.Val2029Met Single submitter ⚠
- p.Val2140Ile Single submitter ⚠
- p.Val2162Ile Single submitter ⚠
- p.Val37Asp Single submitter ⚠
- p.Val534Ile Single submitter ⚠
- p.Val628Ala Single submitter ⚠
- p.Ala391Thr No assertion criteria ⚠
- p.Ser1934_Pro1940del No assertion criteria Kleine-Levin syndrome