MAP4K2 — 113 ClinVar variants
All ClinVar germline MAP4K2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 107 flagged for review →
3 Benign · 3 Likely benign · 107 Uncertain significance
Full MAP4K2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 107
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 63
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MAP4K2 p.Ala183Asp Uncertain significance Single submitter
- MAP4K2 p.Ala405Thr Uncertain significance Single submitter
- MAP4K2 p.Ala487Thr Uncertain significance Single submitter
- MAP4K2 p.Ala790Asp Uncertain significance Single submitter
- MAP4K2 p.Arg111Gln Uncertain significance Single submitter
- MAP4K2 p.Asp29Tyr Uncertain significance Single submitter
- MAP4K2 p.Asp397His Uncertain significance Single submitter
- MAP4K2 p.Asp657His Uncertain significance Single submitter
- MAP4K2 p.Gln244Arg Uncertain significance Single submitter
- MAP4K2 p.Gln705His Uncertain significance Single submitter
- MAP4K2 p.Glu110Val Uncertain significance Single submitter
- MAP4K2 p.Glu300Asp Uncertain significance Single submitter
- MAP4K2 p.Glu324Val Uncertain significance Single submitter
- MAP4K2 p.Glu378Lys Uncertain significance Single submitter
- MAP4K2 p.Glu507Lys Uncertain significance Single submitter
- MAP4K2 p.Glu669Lys Uncertain significance Single submitter
- MAP4K2 p.Glu731Lys Uncertain significance Single submitter
- MAP4K2 p.Gly148Arg Uncertain significance Single submitter
- MAP4K2 p.Gly189Asp Uncertain significance Single submitter
- MAP4K2 p.Gly25Arg Uncertain significance Single submitter
- MAP4K2 p.Gly295Glu Uncertain significance Single submitter
- MAP4K2 p.Gly318Glu Uncertain significance Single submitter
- MAP4K2 p.Gly321Ser Uncertain significance Single submitter
- MAP4K2 p.Gly434Ala Uncertain significance Single submitter
- MAP4K2 p.Gly434Asp Uncertain significance Single submitter
- MAP4K2 p.Gly94Arg Uncertain significance Single submitter
- MAP4K2 p.Gly95Arg Uncertain significance Single submitter
- MAP4K2 p.His126Tyr Uncertain significance Single submitter
- MAP4K2 p.His293Leu Uncertain significance Single submitter
- MAP4K2 p.His315Gln Uncertain significance Single submitter
- MAP4K2 p.His320Arg Uncertain significance Single submitter
- MAP4K2 p.His807Gln Uncertain significance Single submitter
- MAP4K2 p.Ile695Leu Uncertain significance Single submitter
- MAP4K2 p.Ile746Val Uncertain significance Single submitter
- MAP4K2 p.Leu236Gln Uncertain significance Single submitter
- MAP4K2 p.Leu285Pro Uncertain significance Single submitter
- MAP4K2 p.Leu392Val Uncertain significance Single submitter
- MAP4K2 p.Leu3Val Uncertain significance Single submitter
- MAP4K2 p.Leu533Arg Uncertain significance Single submitter
- MAP4K2 p.Met226Thr Uncertain significance Single submitter
- MAP4K2 p.Met226Val Uncertain significance Single submitter
- MAP4K2 p.Pro175Arg Uncertain significance Single submitter
- MAP4K2 p.Pro299Leu Uncertain significance Single submitter
- MAP4K2 p.Pro299Ser Uncertain significance Single submitter
- MAP4K2 p.Pro351Leu Uncertain significance Single submitter
- MAP4K2 p.Pro406Leu Uncertain significance Single submitter
- MAP4K2 p.Pro424Leu Uncertain significance Single submitter
- MAP4K2 p.Pro431Thr Uncertain significance Single submitter
- MAP4K2 p.Pro435Ala Uncertain significance Single submitter
- MAP4K2 p.Pro439Leu Uncertain significance Single submitter
- MAP4K2 p.Pro630Leu Uncertain significance Single submitter
- MAP4K2 p.Ser433Leu Uncertain significance Single submitter
- MAP4K2 p.Ser527Ala Uncertain significance Single submitter
- MAP4K2 p.Ser641Pro Uncertain significance Single submitter
- MAP4K2 p.Ser818Asn Uncertain significance Single submitter
- MAP4K2 p.Ser8Trp Uncertain significance Single submitter
- MAP4K2 p.Ser97Phe Uncertain significance Single submitter
- MAP4K2 p.Thr63Ala Uncertain significance Single submitter
- MAP4K2 p.Val116Ile Uncertain significance Single submitter
- MAP4K2 p.Val477Phe Uncertain significance Single submitter
- MAP4K2 p.Val489Ala Uncertain significance Single submitter
- MAP4K2 p.Val502Leu Uncertain significance Single submitter
- MAP4K2 p.Val682Ile Uncertain significance Single submitter
Predictors split 44
The independent predictors disagree with each other — read with care.
- MAP4K2 p.Ala184Ser Uncertain significance Single submitter
- MAP4K2 p.Ala806Val Uncertain significance Single submitter
- MAP4K2 p.Arg187His Uncertain significance Single submitter
- MAP4K2 p.Arg241Cys Uncertain significance Single submitter
- MAP4K2 p.Arg241His Uncertain significance Single submitter
- MAP4K2 p.Arg279Gln Uncertain significance Single submitter
- MAP4K2 p.Arg341Cys Uncertain significance Single submitter
- MAP4K2 p.Arg404Gln Uncertain significance Single submitter
- MAP4K2 p.Arg529Cys Uncertain significance Single submitter
- MAP4K2 p.Arg602His Uncertain significance Single submitter
- MAP4K2 p.Arg677Cys Uncertain significance Single submitter
- MAP4K2 p.Arg786Gln Uncertain significance Single submitter
- MAP4K2 p.Asn72Ser Uncertain significance Single submitter
- MAP4K2 p.Asn772Ser Uncertain significance Single submitter
- MAP4K2 p.Asn83Asp Uncertain significance Single submitter
- MAP4K2 p.Asp53Glu Uncertain significance Single submitter
- MAP4K2 p.Asp692Asn Uncertain significance Single submitter
- MAP4K2 p.Asp754Asn Uncertain significance Single submitter
- MAP4K2 p.Cys117Ser Uncertain significance Single submitter
- MAP4K2 p.Gly338Asp Uncertain significance Single submitter
- MAP4K2 p.Gly670Arg Uncertain significance Single submitter
- MAP4K2 p.Gly675Ser Uncertain significance Single submitter
- MAP4K2 p.His528Tyr Uncertain significance Single submitter
- MAP4K2 p.Ile715Thr Uncertain significance Single submitter
- MAP4K2 p.Leu736Val Uncertain significance Single submitter
- MAP4K2 p.Lys188Asn Uncertain significance Single submitter
- MAP4K2 p.Lys403Asn Uncertain significance Single submitter
- MAP4K2 p.Lys403Thr Uncertain significance Single submitter
- MAP4K2 p.Lys633Asn Uncertain significance Single submitter
- MAP4K2 p.Pro442Arg Uncertain significance Single submitter
- MAP4K2 p.Pro653Gln Uncertain significance Single submitter
- MAP4K2 p.Pro653Ser Uncertain significance Single submitter
- MAP4K2 p.Ser703Leu Uncertain significance Single submitter
- MAP4K2 p.Ser8Leu Uncertain significance Single submitter
- MAP4K2 p.Thr274Ile Uncertain significance Single submitter
- MAP4K2 p.Thr283Ala Uncertain significance Single submitter
- MAP4K2 p.Thr443Met Uncertain significance Single submitter
- MAP4K2 p.Thr690Met Uncertain significance Single submitter
- MAP4K2 p.Thr814Met Uncertain significance Single submitter
- MAP4K2 p.Tyr27Phe Uncertain significance Single submitter
- MAP4K2 p.Tyr820Cys Uncertain significance Single submitter
- MAP4K2 p.Val502Met Uncertain significance Single submitter
- MAP4K2 p.Val678Ile Uncertain significance Single submitter
- MAP4K2 p.Val682Ala Uncertain significance Single submitter
All MAP4K2 variants
Benign 3
- p.Ala120Ser Multiple submitters
- p.Asn606= Multiple submitters
- p.Ala806= Single submitter
Likely benign 3
- p.Arg792= Single submitter
- p.Glu303Asp Single submitter
- p.Ser227= Single submitter
Uncertain significance 107
- p.Ala183Asp Single submitter ⚠
- p.Ala184Ser Single submitter ⚠
- p.Ala405Thr Single submitter ⚠
- p.Ala487Thr Single submitter ⚠
- p.Ala790Asp Single submitter ⚠
- p.Ala806Val Single submitter ⚠
- p.Arg111Gln Single submitter ⚠
- p.Arg187His Single submitter ⚠
- p.Arg241Cys Single submitter ⚠
- p.Arg241His Single submitter ⚠
- p.Arg279Gln Single submitter ⚠
- p.Arg341Cys Single submitter ⚠
- p.Arg404Gln Single submitter ⚠
- p.Arg529Cys Single submitter ⚠
- p.Arg602His Single submitter ⚠
- p.Arg677Cys Single submitter ⚠
- p.Arg786Gln Single submitter ⚠
- p.Asn72Ser Single submitter ⚠
- p.Asn772Ser Single submitter ⚠
- p.Asn83Asp Single submitter ⚠
- p.Asp29Tyr Single submitter ⚠
- p.Asp397His Single submitter ⚠
- p.Asp53Glu Single submitter ⚠
- p.Asp657His Single submitter ⚠
- p.Asp692Asn Single submitter ⚠
- p.Asp754Asn Single submitter ⚠
- p.Cys117Ser Single submitter ⚠
- p.Gln244Arg Single submitter ⚠
- p.Gln705His Single submitter ⚠
- p.Glu110Val Single submitter ⚠
- p.Glu300Asp Single submitter ⚠
- p.Glu324Val Single submitter ⚠
- p.Glu378Lys Single submitter ⚠
- p.Glu507Lys Single submitter ⚠
- p.Glu669Lys Single submitter ⚠
- p.Glu731Lys Single submitter ⚠
- p.Gly148Arg Single submitter ⚠
- p.Gly189Asp Single submitter ⚠
- p.Gly25Arg Single submitter ⚠
- p.Gly295Glu Single submitter ⚠
- p.Gly318Glu Single submitter ⚠
- p.Gly321Ser Single submitter ⚠
- p.Gly338Asp Single submitter ⚠
- p.Gly434Ala Single submitter ⚠
- p.Gly434Asp Single submitter ⚠
- p.Gly670Arg Single submitter ⚠
- p.Gly675Ser Single submitter ⚠
- p.Gly94Arg Single submitter ⚠
- p.Gly95Arg Single submitter ⚠
- p.His126Tyr Single submitter ⚠
- p.His293Leu Single submitter ⚠
- p.His315Gln Single submitter ⚠
- p.His320Arg Single submitter ⚠
- p.His528Tyr Single submitter ⚠
- p.His807Gln Single submitter ⚠
- p.Ile695Leu Single submitter ⚠
- p.Ile715Thr Single submitter ⚠
- p.Ile746Val Single submitter ⚠
- p.Leu236Gln Single submitter ⚠
- p.Leu285Pro Single submitter ⚠
- p.Leu392Val Single submitter ⚠
- p.Leu3Val Single submitter ⚠
- p.Leu533Arg Single submitter ⚠
- p.Leu736Val Single submitter ⚠
- p.Lys188Asn Single submitter ⚠
- p.Lys403Asn Single submitter ⚠
- p.Lys403Thr Single submitter ⚠
- p.Lys633Asn Single submitter ⚠
- p.Met226Thr Single submitter ⚠
- p.Met226Val Single submitter ⚠
- p.Pro175Arg Single submitter ⚠
- p.Pro299Leu Single submitter ⚠
- p.Pro299Ser Single submitter ⚠
- p.Pro351Leu Single submitter ⚠
- p.Pro406Leu Single submitter ⚠
- p.Pro424Leu Single submitter ⚠
- p.Pro431Thr Single submitter ⚠
- p.Pro435Ala Single submitter ⚠
- p.Pro439Leu Single submitter ⚠
- p.Pro442Arg Single submitter ⚠
- p.Pro630Leu Single submitter ⚠
- p.Pro653Gln Single submitter ⚠
- p.Pro653Ser Single submitter ⚠
- p.Ser433Leu Single submitter ⚠
- p.Ser527Ala Single submitter ⚠
- p.Ser641Pro Single submitter ⚠
- p.Ser703Leu Single submitter ⚠
- p.Ser818Asn Single submitter ⚠
- p.Ser8Leu Single submitter ⚠
- p.Ser8Trp Single submitter ⚠
- p.Ser97Phe Single submitter ⚠
- p.Thr274Ile Single submitter ⚠
- p.Thr283Ala Single submitter ⚠
- p.Thr443Met Single submitter ⚠
- p.Thr63Ala Single submitter ⚠
- p.Thr690Met Single submitter ⚠
- p.Thr814Met Single submitter ⚠
- p.Tyr27Phe Single submitter ⚠
- p.Tyr820Cys Single submitter ⚠
- p.Val116Ile Single submitter ⚠
- p.Val477Phe Single submitter ⚠
- p.Val489Ala Single submitter ⚠
- p.Val502Leu Single submitter ⚠
- p.Val502Met Single submitter ⚠
- p.Val678Ile Single submitter ⚠
- p.Val682Ala Single submitter ⚠
- p.Val682Ile Single submitter ⚠