MAP4K3 — 105 ClinVar variants
All ClinVar germline MAP4K3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 95 flagged for review →
8 Likely benign · 97 Uncertain significance
Full MAP4K3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 95
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 75
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MAP4K3 p.Ala310Val Uncertain significance Single submitter
- MAP4K3 p.Ala391Glu Uncertain significance Single submitter
- MAP4K3 p.Ala429Val Uncertain significance Single submitter
- MAP4K3 p.Ala621Thr Uncertain significance Single submitter
- MAP4K3 p.Arg482Lys Uncertain significance Single submitter
- MAP4K3 p.Arg504Gln Uncertain significance Single submitter
- MAP4K3 p.Arg602Gln Uncertain significance Single submitter
- MAP4K3 p.Arg637Lys Uncertain significance Single submitter
- MAP4K3 p.Arg744Lys Uncertain significance Single submitter
- MAP4K3 p.Arg753Gln Uncertain significance Single submitter
- MAP4K3 p.Arg873Lys Uncertain significance Single submitter
- MAP4K3 p.Asn372Ser Uncertain significance Single submitter
- MAP4K3 p.Asn760His Uncertain significance Single submitter
- MAP4K3 p.Asp216Glu Uncertain significance Single submitter
- MAP4K3 p.Asp356Val Uncertain significance Single submitter
- MAP4K3 p.Asp414Glu Uncertain significance Single submitter
- MAP4K3 p.Asp527Asn Uncertain significance Single submitter
- MAP4K3 p.Cys555Ser Uncertain significance Single submitter
- MAP4K3 p.Cys720Arg Uncertain significance Single submitter
- MAP4K3 p.Gln381Arg Uncertain significance Single submitter
- MAP4K3 p.Gln473Glu Uncertain significance Single submitter
- MAP4K3 p.Gln473His Uncertain significance Single submitter
- MAP4K3 p.Glu325Gly Uncertain significance Single submitter
- MAP4K3 p.Glu378Gln Uncertain significance Single submitter
- MAP4K3 p.Gly334Asp Uncertain significance Single submitter
- MAP4K3 p.Gly386Val Uncertain significance Single submitter
- MAP4K3 p.Gly494Ala Uncertain significance Single submitter
- MAP4K3 p.Gly506Ser Uncertain significance Single submitter
- MAP4K3 p.Gly631Glu Uncertain significance Single submitter
- MAP4K3 p.His103Tyr Uncertain significance Single submitter
- MAP4K3 p.His449Leu Uncertain significance Single submitter
- MAP4K3 p.His486Arg Uncertain significance Single submitter
- MAP4K3 p.His515Arg Uncertain significance Single submitter
- MAP4K3 p.His515Leu Uncertain significance Single submitter
- MAP4K3 p.His592Pro Uncertain significance Single submitter
- MAP4K3 p.Ile165Val Uncertain significance Single submitter
- MAP4K3 p.Ile283Thr Uncertain significance Single submitter
- MAP4K3 p.Ile442Val Uncertain significance Single submitter
- MAP4K3 p.Ile444Leu Uncertain significance Single submitter
- MAP4K3 p.Ile696Val Uncertain significance Single submitter
- MAP4K3 p.Ile714Met Uncertain significance Single submitter
- MAP4K3 p.Ile718Val Uncertain significance Single submitter
- MAP4K3 p.Ile787Val Uncertain significance Single submitter
- MAP4K3 p.Ile823Val Uncertain significance Single submitter
- MAP4K3 p.Leu342Ile Uncertain significance Single submitter
- MAP4K3 p.Leu377Gln Uncertain significance Single submitter
- MAP4K3 p.Leu624Pro Uncertain significance Single submitter
- MAP4K3 p.Leu791Val Uncertain significance Single submitter
- MAP4K3 p.Lys809Glu Uncertain significance Single submitter
- MAP4K3 p.Met495Leu Uncertain significance Single submitter
- MAP4K3 p.Phe816Cys Uncertain significance Single submitter
- MAP4K3 p.Pro340Ala Uncertain significance Single submitter
- MAP4K3 p.Ser496Arg Uncertain significance Single submitter
- MAP4K3 p.Ser521Thr Uncertain significance Single submitter
- MAP4K3 p.Ser743Arg Uncertain significance Single submitter
- MAP4K3 p.Ser743Gly Uncertain significance Single submitter
- MAP4K3 p.Ser769Thr Uncertain significance Single submitter
- MAP4K3 p.Ser864Phe Uncertain significance Single submitter
- MAP4K3 p.Thr162Ile Uncertain significance Single submitter
- MAP4K3 p.Thr296Ala Uncertain significance Single submitter
- MAP4K3 p.Thr451Ile Uncertain significance Single submitter
- MAP4K3 p.Thr771Asn Uncertain significance Single submitter
- MAP4K3 p.Thr815Ile Uncertain significance Single submitter
- MAP4K3 p.Thr849Ile Uncertain significance Single submitter
- MAP4K3 p.Tyr687Asp Uncertain significance Single submitter
- MAP4K3 p.Val273Ile Uncertain significance Single submitter
- MAP4K3 p.Val309Phe Uncertain significance Single submitter
- MAP4K3 p.Val322Met Uncertain significance Single submitter
- MAP4K3 p.Val409Ile Uncertain significance Single submitter
- MAP4K3 p.Val528Ile Uncertain significance Single submitter
- MAP4K3 p.Val551Asp Uncertain significance Single submitter
- MAP4K3 p.Val609Ile Uncertain significance Single submitter
- MAP4K3 p.Val697Ile Uncertain significance Single submitter
- MAP4K3 p.Val751Glu Uncertain significance Single submitter
-
MAP4K3 p.Phe300Ser
Uncertain significance
No assertion criteria
ependymoma
Predictors split 20
The independent predictors disagree with each other — read with care.
- MAP4K3 p.Ala253Thr Uncertain significance Single submitter
- MAP4K3 p.Ala664Pro Uncertain significance Single submitter
- MAP4K3 p.Ala75Thr Uncertain significance Single submitter
- MAP4K3 p.Arg753Leu Uncertain significance Single submitter
- MAP4K3 p.Arg844Ile Uncertain significance Single submitter
- MAP4K3 p.Asn758Ser Uncertain significance Single submitter
- MAP4K3 p.Asn760Asp Uncertain significance Single submitter
- MAP4K3 p.Asp293His Uncertain significance Single submitter
- MAP4K3 p.Gln640Glu Uncertain significance Single submitter
- MAP4K3 p.Gln706Arg Uncertain significance Single submitter
- MAP4K3 p.Ile576Val Uncertain significance Single submitter
- MAP4K3 p.Leu403Phe Uncertain significance Single submitter
- MAP4K3 p.Lys241Asn Uncertain significance Single submitter
- MAP4K3 p.Met220Leu Uncertain significance Single submitter
- MAP4K3 p.Phe600Leu Uncertain significance Single submitter
- MAP4K3 p.Phe816Tyr Uncertain significance Single submitter
- MAP4K3 p.Pro719Thr Uncertain significance Single submitter
- MAP4K3 p.Ser743Ile Uncertain significance Single submitter
- MAP4K3 p.Thr683Ala Uncertain significance Single submitter
- MAP4K3 p.Tyr735His Uncertain significance Single submitter
All MAP4K3 variants
Likely benign 8
- c.1474+5T>C Single submitter
- c.998-9C>A Single submitter
- p.His350= Single submitter
- p.Ile532Val Single submitter
- p.Leu599= Single submitter
- p.Val200Leu Single submitter
- p.Val489Ile Single submitter
- c.311-2A>G No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
Uncertain significance 97
- p.Ala253Thr Single submitter ⚠
- p.Ala310Val Single submitter ⚠
- p.Ala391Glu Single submitter ⚠
- p.Ala429Val Single submitter ⚠
- p.Ala621Thr Single submitter ⚠
- p.Ala664Pro Single submitter ⚠
- p.Ala75Thr Single submitter ⚠
- p.Arg482Lys Single submitter ⚠
- p.Arg504Gln Single submitter ⚠
- p.Arg602Gln Single submitter ⚠
- p.Arg637Lys Single submitter ⚠
- p.Arg744Lys Single submitter ⚠
- p.Arg753Gln Single submitter ⚠
- p.Arg753Leu Single submitter ⚠
- p.Arg844Ile Single submitter ⚠
- p.Arg873Lys Single submitter ⚠
- p.Asn372Ser Single submitter ⚠
- p.Asn758Ser Single submitter ⚠
- p.Asn760Asp Single submitter ⚠
- p.Asn760His Single submitter ⚠
- p.Asp216Glu Single submitter ⚠
- p.Asp293His Single submitter ⚠
- p.Asp356Val Single submitter ⚠
- p.Asp414Glu Single submitter ⚠
- p.Asp527Asn Single submitter ⚠
- p.Cys555Ser Single submitter ⚠
- p.Cys720Arg Single submitter ⚠
- p.Gln381Arg Single submitter ⚠
- p.Gln473Glu Single submitter ⚠
- p.Gln473His Single submitter ⚠
- p.Gln640Glu Single submitter ⚠
- p.Gln706Arg Single submitter ⚠
- p.Glu325Gly Single submitter ⚠
- p.Glu378Gln Single submitter ⚠
- p.Gly334Asp Single submitter ⚠
- p.Gly386Val Single submitter ⚠
- p.Gly494Ala Single submitter ⚠
- p.Gly506Ser Single submitter ⚠
- p.Gly631Glu Single submitter ⚠
- p.His103Tyr Single submitter ⚠
- p.His449Leu Single submitter ⚠
- p.His486Arg Single submitter ⚠
- p.His515Arg Single submitter ⚠
- p.His515Leu Single submitter ⚠
- p.His560Arg Single submitter
- p.His592Pro Single submitter ⚠
- p.Ile165Val Single submitter ⚠
- p.Ile283Thr Single submitter ⚠
- p.Ile442Val Single submitter ⚠
- p.Ile444Leu Single submitter ⚠
- p.Ile576Val Single submitter ⚠
- p.Ile696Val Single submitter ⚠
- p.Ile714Met Single submitter ⚠
- p.Ile718Val Single submitter ⚠
- p.Ile787Val Single submitter ⚠
- p.Ile823Val Single submitter ⚠
- p.Leu342Ile Single submitter ⚠
- p.Leu377Gln Single submitter ⚠
- p.Leu403Phe Single submitter ⚠
- p.Leu624Pro Single submitter ⚠
- p.Leu791Val Single submitter ⚠
- p.Lys241Asn Single submitter ⚠
- p.Lys809Glu Single submitter ⚠
- p.Met220Leu Single submitter ⚠
- p.Met495Leu Single submitter ⚠
- p.Phe600Leu Single submitter ⚠
- p.Phe816Cys Single submitter ⚠
- p.Phe816Tyr Single submitter ⚠
- p.Pro340Ala Single submitter ⚠
- p.Pro719Thr Single submitter ⚠
- p.Ser496Arg Single submitter ⚠
- p.Ser521Thr Single submitter ⚠
- p.Ser743Arg Single submitter ⚠
- p.Ser743Gly Single submitter ⚠
- p.Ser743Ile Single submitter ⚠
- p.Ser769Thr Single submitter ⚠
- p.Ser864Phe Single submitter ⚠
- p.Ser882Cys Single submitter
- p.Thr162Ile Single submitter ⚠
- p.Thr296Ala Single submitter ⚠
- p.Thr451Ile Single submitter ⚠
- p.Thr683Ala Single submitter ⚠
- p.Thr771Asn Single submitter ⚠
- p.Thr815Ile Single submitter ⚠
- p.Thr849Ile Single submitter ⚠
- p.Tyr687Asp Single submitter ⚠
- p.Tyr735His Single submitter ⚠
- p.Val273Ile Single submitter ⚠
- p.Val309Phe Single submitter ⚠
- p.Val322Met Single submitter ⚠
- p.Val409Ile Single submitter ⚠
- p.Val528Ile Single submitter ⚠
- p.Val551Asp Single submitter ⚠
- p.Val609Ile Single submitter ⚠
- p.Val697Ile Single submitter ⚠
- p.Val751Glu Single submitter ⚠
- p.Phe300Ser No assertion criteria ependymoma ⚠