Sugi Variant

Sugi Variant/MAP4K4

MAP4K4 — 246 ClinVar variants

All ClinVar germline MAP4K4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 139 flagged for review →

4 Pathogenic · 1 Pathogenic/Likely pathogenic · 10 Likely pathogenic · 1 Conflicting · 44 Benign · 11 Likely benign · 175 Uncertain significance

Full MAP4K4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 139

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 95

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 42

The independent predictors disagree with each other — read with care.

All MAP4K4 variants

Pathogenic 4

Pathogenic/Likely pathogenic 1

Likely pathogenic 10

Conflicting classifications of pathogenicity 1

Benign 44

Likely benign 11

Uncertain significance 175