MAP4K5 — 108 ClinVar variants
All ClinVar germline MAP4K5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 100 flagged for review →
1 Benign · 3 Likely benign · 104 Uncertain significance
Full MAP4K5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 100
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 75
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MAP4K5 p.Val739Ile Uncertain significance Multiple submitters
- MAP4K5 p.Ala278Thr Uncertain significance Single submitter
- MAP4K5 p.Ala328Val Uncertain significance Single submitter
- MAP4K5 p.Ala37Val Uncertain significance Single submitter
- MAP4K5 p.Ala425Thr Uncertain significance Single submitter
- MAP4K5 p.Ala464Thr Uncertain significance Single submitter
- MAP4K5 p.Ala611Thr Uncertain significance Single submitter
- MAP4K5 p.Ala721Thr Uncertain significance Single submitter
- MAP4K5 p.Ala763Val Uncertain significance Single submitter
- MAP4K5 p.Arg318His Uncertain significance Single submitter
- MAP4K5 p.Arg355Gly Uncertain significance Single submitter
- MAP4K5 p.Arg386Cys Uncertain significance Single submitter
- MAP4K5 p.Arg476Gln Uncertain significance Single submitter
- MAP4K5 p.Arg604Leu Uncertain significance Single submitter
- MAP4K5 p.Arg771His Uncertain significance Single submitter
- MAP4K5 p.Arg87Trp Uncertain significance Single submitter
- MAP4K5 p.Asn295Lys Uncertain significance Single submitter
- MAP4K5 p.Asn378Asp Uncertain significance Single submitter
- MAP4K5 p.Asn405His Uncertain significance Single submitter
- MAP4K5 p.Asp220Gly Uncertain significance Single submitter
- MAP4K5 p.Asp220Tyr Uncertain significance Single submitter
- MAP4K5 p.Asp363His Uncertain significance Single submitter
- MAP4K5 p.Cys554Gly Uncertain significance Single submitter
- MAP4K5 p.Gln236His Uncertain significance Single submitter
- MAP4K5 p.Gln24Arg Uncertain significance Single submitter
- MAP4K5 p.Gln369Lys Uncertain significance Single submitter
- MAP4K5 p.Gln63Glu Uncertain significance Single submitter
- MAP4K5 p.Gln63His Uncertain significance Single submitter
- MAP4K5 p.Glu409Lys Uncertain significance Single submitter
- MAP4K5 p.Glu442Lys Uncertain significance Single submitter
- MAP4K5 p.Glu843Lys Uncertain significance Single submitter
- MAP4K5 p.Gly100Arg Uncertain significance Single submitter
- MAP4K5 p.Gly720Asp Uncertain significance Single submitter
- MAP4K5 p.Gly792Cys Uncertain significance Single submitter
- MAP4K5 p.His302Arg Uncertain significance Single submitter
- MAP4K5 p.His599Gln Uncertain significance Single submitter
- MAP4K5 p.His623Arg Uncertain significance Single submitter
- MAP4K5 p.Ile11Val Uncertain significance Single submitter
- MAP4K5 p.Ile165Thr Uncertain significance Single submitter
- MAP4K5 p.Ile256Val Uncertain significance Single submitter
- MAP4K5 p.Ile316Val Uncertain significance Single submitter
- MAP4K5 p.Ile452Val Uncertain significance Single submitter
- MAP4K5 p.Ile516Lys Uncertain significance Single submitter
- MAP4K5 p.Ile581Thr Uncertain significance Single submitter
- MAP4K5 p.Leu360Ser Uncertain significance Single submitter
- MAP4K5 p.Leu392Val Uncertain significance Single submitter
- MAP4K5 p.Leu580Phe Uncertain significance Single submitter
- MAP4K5 p.Lys472Glu Uncertain significance Single submitter
- MAP4K5 p.Lys571Asn Uncertain significance Single submitter
- MAP4K5 p.Lys588Arg Uncertain significance Single submitter
- MAP4K5 p.Met494Val Uncertain significance Single submitter
- MAP4K5 p.Phe175Cys Uncertain significance Single submitter
- MAP4K5 p.Pro407Ala Uncertain significance Single submitter
- MAP4K5 p.Pro419Thr Uncertain significance Single submitter
- MAP4K5 p.Pro435Ala Uncertain significance Single submitter
- MAP4K5 p.Pro481Leu Uncertain significance Single submitter
- MAP4K5 p.Pro4Arg Uncertain significance Single submitter
- MAP4K5 p.Pro7Leu Uncertain significance Single submitter
- MAP4K5 p.Ser362Pro Uncertain significance Single submitter
- MAP4K5 p.Ser400Gly Uncertain significance Single submitter
- MAP4K5 p.Ser423Gly Uncertain significance Single submitter
- MAP4K5 p.Ser445Phe Uncertain significance Single submitter
- MAP4K5 p.Ser698Leu Uncertain significance Single submitter
- MAP4K5 p.Ser781Asn Uncertain significance Single submitter
- MAP4K5 p.Thr267Pro Uncertain significance Single submitter
- MAP4K5 p.Thr383Pro Uncertain significance Single submitter
- MAP4K5 p.Thr42Ile Uncertain significance Single submitter
- MAP4K5 p.Thr598Ser Uncertain significance Single submitter
- MAP4K5 p.Thr831Ala Uncertain significance Single submitter
- MAP4K5 p.Trp515Cys Uncertain significance Single submitter
- MAP4K5 p.Trp91Cys Uncertain significance Single submitter
- MAP4K5 p.Tyr119Cys Uncertain significance Single submitter
- MAP4K5 p.Tyr35Cys Uncertain significance Single submitter
- MAP4K5 p.Tyr401Cys Uncertain significance Single submitter
- MAP4K5 p.Val821Ile Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- MAP4K5 p.Ala611Val Uncertain significance Single submitter
- MAP4K5 p.Arg318Cys Uncertain significance Single submitter
- MAP4K5 p.Arg552Gln Uncertain significance Single submitter
- MAP4K5 p.Arg812Cys Uncertain significance Single submitter
- MAP4K5 p.Arg812His Uncertain significance Single submitter
- MAP4K5 p.Asn15Lys Uncertain significance Single submitter
- MAP4K5 p.Asn484Ser Uncertain significance Single submitter
- MAP4K5 p.Asp153Gly Uncertain significance Single submitter
- MAP4K5 p.Gln17Pro Uncertain significance Single submitter
- MAP4K5 p.Gln791Arg Uncertain significance Single submitter
- MAP4K5 p.Glu269Gln Uncertain significance Single submitter
- MAP4K5 p.Glu44Ala Uncertain significance Single submitter
- MAP4K5 p.Gly645Arg Uncertain significance Single submitter
- MAP4K5 p.His663Asp Uncertain significance Single submitter
- MAP4K5 p.His833Arg Uncertain significance Single submitter
- MAP4K5 p.Ile209Val Uncertain significance Single submitter
- MAP4K5 p.Ile560Thr Uncertain significance Single submitter
- MAP4K5 p.Leu778Ile Uncertain significance Single submitter
- MAP4K5 p.Met230Ile Uncertain significance Single submitter
- MAP4K5 p.Met687Ile Uncertain significance Single submitter
- MAP4K5 p.Pro391Ser Uncertain significance Single submitter
- MAP4K5 p.Thr572Pro Uncertain significance Single submitter
- MAP4K5 p.Thr831Ile Uncertain significance Single submitter
- MAP4K5 p.Val23Phe Uncertain significance Single submitter
- MAP4K5 p.Val288Phe Uncertain significance Single submitter
All MAP4K5 variants
Benign 1
- p.Val731= Multiple submitters
Likely benign 3
- p.Met456Ile Single submitter
- p.Phe406Leu Single submitter
- p.Val40Ile Single submitter
Uncertain significance 104
- p.Val739Ile Multiple submitters ⚠
- c.1709-2A>T Single submitter
- p.Ala278Thr Single submitter ⚠
- p.Ala328Val Single submitter ⚠
- p.Ala37Val Single submitter ⚠
- p.Ala425Thr Single submitter ⚠
- p.Ala464Thr Single submitter ⚠
- p.Ala611Thr Single submitter ⚠
- p.Ala611Val Single submitter ⚠
- p.Ala721Thr Single submitter ⚠
- p.Ala763Val Single submitter ⚠
- p.Arg318Cys Single submitter ⚠
- p.Arg318His Single submitter ⚠
- p.Arg355Gly Single submitter ⚠
- p.Arg386Cys Single submitter ⚠
- p.Arg476Gln Single submitter ⚠
- p.Arg552Gln Single submitter ⚠
- p.Arg604Leu Single submitter ⚠
- p.Arg771His Single submitter ⚠
- p.Arg812Cys Single submitter ⚠
- p.Arg812His Single submitter ⚠
- p.Arg87Trp Single submitter ⚠
- p.Asn15Lys Single submitter ⚠
- p.Asn295Lys Single submitter ⚠
- p.Asn378Asp Single submitter ⚠
- p.Asn405His Single submitter ⚠
- p.Asn484Ser Single submitter ⚠
- p.Asp153Gly Single submitter ⚠
- p.Asp220Gly Single submitter ⚠
- p.Asp220Tyr Single submitter ⚠
- p.Asp363His Single submitter ⚠
- p.Asp450fs Single submitter
- p.Cys554Gly Single submitter ⚠
- p.Gln17Pro Single submitter ⚠
- p.Gln236His Single submitter ⚠
- p.Gln24Arg Single submitter ⚠
- p.Gln369Lys Single submitter ⚠
- p.Gln63Glu Single submitter ⚠
- p.Gln63His Single submitter ⚠
- p.Gln791Arg Single submitter ⚠
- p.Glu269Gln Single submitter ⚠
- p.Glu409Lys Single submitter ⚠
- p.Glu442Lys Single submitter ⚠
- p.Glu44Ala Single submitter ⚠
- p.Glu843Lys Single submitter ⚠
- p.Gly100Arg Single submitter ⚠
- p.Gly645Arg Single submitter ⚠
- p.Gly720Asp Single submitter ⚠
- p.Gly792Cys Single submitter ⚠
- p.His302Arg Single submitter ⚠
- p.His599Gln Single submitter ⚠
- p.His623Arg Single submitter ⚠
- p.His663Asp Single submitter ⚠
- p.His833Arg Single submitter ⚠
- p.Ile11Val Single submitter ⚠
- p.Ile165Thr Single submitter ⚠
- p.Ile209Val Single submitter ⚠
- p.Ile256Val Single submitter ⚠
- p.Ile316Val Single submitter ⚠
- p.Ile452Val Single submitter ⚠
- p.Ile516Lys Single submitter ⚠
- p.Ile560Thr Single submitter ⚠
- p.Ile581Thr Single submitter ⚠
- p.Leu360Ser Single submitter ⚠
- p.Leu392Val Single submitter ⚠
- p.Leu580Phe Single submitter ⚠
- p.Leu778Ile Single submitter ⚠
- p.Lys472Glu Single submitter ⚠
- p.Lys571Asn Single submitter ⚠
- p.Lys588Arg Single submitter ⚠
- p.Met230Ile Single submitter ⚠
- p.Met494Val Single submitter ⚠
- p.Met687Ile Single submitter ⚠
- p.Met68Val Single submitter
- p.Phe175Cys Single submitter ⚠
- p.Pro391Ser Single submitter ⚠
- p.Pro407Ala Single submitter ⚠
- p.Pro419Thr Single submitter ⚠
- p.Pro435Ala Single submitter ⚠
- p.Pro481Leu Single submitter ⚠
- p.Pro4Arg Single submitter ⚠
- p.Pro7Leu Single submitter ⚠
- p.Ser362Pro Single submitter ⚠
- p.Ser400Gly Single submitter ⚠
- p.Ser423Gly Single submitter ⚠
- p.Ser445Phe Single submitter ⚠
- p.Ser698Leu Single submitter ⚠
- p.Ser781Asn Single submitter ⚠
- p.Thr267Pro Single submitter ⚠
- p.Thr383Pro Single submitter ⚠
- p.Thr42Ile Single submitter ⚠
- p.Thr572Pro Single submitter ⚠
- p.Thr598Ser Single submitter ⚠
- p.Thr831Ala Single submitter ⚠
- p.Thr831Ile Single submitter ⚠
- p.Trp515Cys Single submitter ⚠
- p.Trp91Cys Single submitter ⚠
- p.Tyr119Cys Single submitter ⚠
- p.Tyr35Cys Single submitter ⚠
- p.Tyr401Cys Single submitter ⚠
- p.Val23Phe Single submitter ⚠
- p.Val288Phe Single submitter ⚠
- p.Val819Ile Single submitter
- p.Val821Ile Single submitter ⚠