MAP7 — 150 ClinVar variants

All ClinVar germline MAP7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 131 flagged for review →

1 Benign · 5 Likely benign · 144 Uncertain significance

Full MAP7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 131

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 99

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 32

The independent predictors disagree with each other — read with care.

All MAP7 variants

Benign 1

p.Ile257Asn Single submitter

Likely benign 5

p.Ala615Thr Single submitter
p.Arg106= Single submitter
p.Arg502Lys Single submitter
p.Ser435Thr Single submitter
p.Thr310Ile Single submitter

Uncertain significance 144

p.Arg214Cys Multiple submitters ⚠
c.1274-1G>C Single submitter
c.67+24403G>A Single submitter
c.67+24406A>G Single submitter
c.67+24434G>T Single submitter
c.68-44980del Single submitter
c.752-21T>C Single submitter
c.752-6G>A Single submitter
p.Ala141_Val142insLys Single submitter
p.Ala17Val Single submitter ⚠
p.Ala292Glu Single submitter ⚠
p.Ala321Val Single submitter ⚠
p.Ala426Gly Single submitter ⚠
p.Ala432Pro Single submitter ⚠
p.Ala434Gly Single submitter ⚠
p.Ala471Thr Single submitter
p.Ala471Val Single submitter ⚠
p.Ala520Thr Single submitter ⚠
p.Ala564Ser Single submitter ⚠
p.Ala564Thr Single submitter ⚠
p.Ala629Ser Single submitter ⚠
p.Ala629Val Single submitter ⚠
p.Ala648Thr Single submitter ⚠
p.Ala83Gly Single submitter ⚠
p.Arg119Gln Single submitter ⚠
p.Arg120Thr Single submitter ⚠
p.Arg128Gln Single submitter ⚠
p.Arg128Gly Single submitter ⚠
p.Arg138Cys Single submitter ⚠
p.Arg144Gln Single submitter ⚠
p.Arg144Trp Single submitter ⚠
p.Arg145Cys Single submitter ⚠
p.Arg159Cys Single submitter ⚠
p.Arg159His Single submitter ⚠
p.Arg198Gln Single submitter ⚠
p.Arg198Trp Single submitter ⚠
p.Arg214His Single submitter ⚠
p.Arg215His Single submitter ⚠
p.Arg284Cys Single submitter ⚠
p.Arg284His Single submitter ⚠
p.Arg326His Single submitter ⚠
p.Arg344Thr Single submitter ⚠
p.Arg370Cys Single submitter ⚠
p.Arg415Trp Single submitter ⚠
p.Arg488Trp Single submitter ⚠
p.Arg491Gln Single submitter ⚠
p.Arg523Lys Single submitter ⚠
p.Arg527Gly Single submitter ⚠
p.Arg527His Single submitter ⚠
p.Arg532Cys Single submitter ⚠
p.Arg532Leu Single submitter ⚠
p.Arg540Gly Single submitter ⚠
p.Arg548Pro Single submitter ⚠
p.Arg548Trp Single submitter ⚠
p.Arg553Gly Single submitter ⚠
p.Arg553Pro Single submitter ⚠
p.Arg556His Single submitter ⚠
p.Arg573Cys Single submitter
p.Arg585Gln Single submitter ⚠
p.Arg66Gln Single submitter ⚠
p.Arg66Trp Single submitter ⚠
p.Arg68Gln Single submitter ⚠
p.Arg71Trp Single submitter ⚠
p.Arg74His Single submitter ⚠
p.Arg77Gln Single submitter ⚠
p.Arg77Trp Single submitter ⚠
p.Arg94Gln Single submitter ⚠
p.Arg94Gly Single submitter ⚠
p.Asn318Asp Single submitter ⚠
p.Asp25Asn Single submitter ⚠
p.Asp31Asn Single submitter ⚠
p.Asp384Asn Single submitter ⚠
p.Asp726Gly Single submitter ⚠
p.Gln323Arg Single submitter ⚠
p.Gln665Pro Single submitter ⚠
p.Glu478Gly Single submitter ⚠
p.Glu492Gln Single submitter
p.Glu495Lys Single submitter ⚠
p.Glu530Ala Single submitter ⚠
p.Glu537Lys Single submitter ⚠
p.Glu584Lys Single submitter
p.Glu598Gly Single submitter ⚠
p.Glu716Gly Single submitter ⚠
p.Glu72Lys Single submitter ⚠
p.Glu78Asp Single submitter ⚠
p.Gly10Ser Single submitter ⚠
p.Gly163Glu Single submitter ⚠
p.Gly341Asp Single submitter ⚠
p.Gly352Ser Single submitter ⚠
p.Gly626Cys Single submitter ⚠
p.Gly631Arg Single submitter ⚠
p.Gly701Arg Single submitter ⚠
p.Gly7Asp Single submitter ⚠
p.His157Asp Single submitter ⚠
p.His234Tyr Single submitter ⚠
p.His664Gln Single submitter ⚠
p.His664Tyr Single submitter ⚠
p.Ile700Thr Single submitter ⚠
p.Ile86Met Single submitter ⚠
p.Leu81Gln Single submitter ⚠
p.Lys107Met Single submitter ⚠
p.Lys152Thr Single submitter ⚠
p.Lys241Asn Single submitter ⚠
p.Lys54Thr Single submitter ⚠
p.Lys601Glu Single submitter ⚠
p.Lys618Thr Single submitter ⚠
p.Met147Val Single submitter ⚠
p.Pro177Thr Single submitter ⚠
p.Pro324Ser Single submitter ⚠
p.Pro345Leu Single submitter ⚠
p.Pro385Thr Single submitter ⚠
p.Pro389Arg Single submitter ⚠
p.Pro389Leu Single submitter ⚠
p.Pro389Ser Single submitter ⚠
p.Pro403Ser Single submitter ⚠
p.Pro447Leu Single submitter ⚠
p.Pro58Leu Single submitter ⚠
p.Pro704Gln Single submitter ⚠
p.Ser150Asn Single submitter ⚠
p.Ser161Trp Single submitter ⚠
p.Ser169Thr Single submitter ⚠
p.Ser171Ile Single submitter ⚠
p.Ser181Ala Single submitter ⚠
p.Ser235Leu Single submitter ⚠
p.Ser268Trp Single submitter ⚠
p.Ser282Cys Single submitter ⚠
p.Ser308Tyr Single submitter ⚠
p.Ser327Phe Single submitter ⚠
p.Ser455Leu Single submitter ⚠
p.Ser459Ala Single submitter ⚠
p.Ser531Pro Single submitter ⚠
p.Thr231Met Single submitter ⚠
p.Thr474Ala Single submitter
p.Thr620Ser Single submitter ⚠
p.Thr673Pro Single submitter ⚠
p.Trp330Arg Single submitter ⚠
p.Val142Leu Single submitter ⚠
p.Val194Ile Single submitter ⚠
p.Val29Ala Single submitter ⚠
p.Val29Met Single submitter ⚠
p.Val314Ala Single submitter ⚠
p.Val467Ile Single submitter ⚠
p.Val670Leu Single submitter ⚠
p.Val709Ile Single submitter ⚠