MAPK10 — 44 ClinVar variants
All ClinVar germline MAPK10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 22 flagged for review →
4 Benign · 1 Benign/Likely benign · 13 Likely benign · 26 Uncertain significance
Full MAPK10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 22
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
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MAPK10 p.Ala353Thr
Uncertain significance
Single submitter
Epileptic encephalopathy with cognitive deficit
- MAPK10 p.Asn89Ser Uncertain significance Single submitter
- MAPK10 p.Asp141Glu Uncertain significance Single submitter
- MAPK10 p.Asp267Gly Uncertain significance Single submitter
- MAPK10 p.Cys79Gly Uncertain significance Single submitter
- MAPK10 p.Glu369Lys Uncertain significance Single submitter
- MAPK10 p.His36Arg Uncertain significance Single submitter
- MAPK10 p.Ile246Val Uncertain significance Single submitter
- MAPK10 p.Leu14Phe Uncertain significance Single submitter
- MAPK10 p.Leu169Pro Uncertain significance Single submitter
- MAPK10 p.Lys260Arg Uncertain significance Single submitter
- MAPK10 p.Lys41Gln Uncertain significance Single submitter
- MAPK10 p.Phe48Leu Uncertain significance Single submitter
- MAPK10 p.Pro459Ser Uncertain significance Single submitter
- MAPK10 p.Ser96Gly Uncertain significance Single submitter
- MAPK10 p.Thr441Ala Uncertain significance Single submitter
- MAPK10 p.Tyr32Phe Uncertain significance Single submitter
- MAPK10 p.Tyr7Cys Uncertain significance Single submitter
-
MAPK10 p.Ser424Asn
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 3
The independent predictors disagree with each other — read with care.
All MAPK10 variants
Benign 4
- p.Ala320= Multiple submitters
- p.Asp351= Multiple submitters
- c.1111-6C>T Single submitter
- p.Asn360= Single submitter
Benign/Likely benign 1
- p.Val113= Multiple submitters
Likely benign 13
- c.1174+14T>A Single submitter
- c.803-13G>C Single submitter
- c.-7+20A>G Single submitter
- p.Glu111= Single submitter
- p.Lys116= Single submitter
- p.Pro310= Single submitter
- p.Thr202= Single submitter
- p.Tyr8= Single submitter
- c.1252+4C>T No assertion criteria MAPK10-related disorder
- c.237-10A>G No assertion criteria MAPK10-related disorder
- c.426-5_426-3dup No assertion criteria MAPK10-related disorder
- p.Gly408Val No assertion criteria MAPK10-related disorder
- p.Ser431= No assertion criteria MAPK10-related disorder
Uncertain significance 26
- c.*1146_*1150del Single submitter
- p.Ala353Thr Single submitter Epileptic encephalopathy with cognitive deficit ⚠
- p.Asn89Ser Single submitter ⚠
- p.Asp141Glu Single submitter ⚠
- p.Asp267Gly Single submitter ⚠
- p.Asp315Asn Single submitter
- p.Cys79Gly Single submitter ⚠
- p.Glu369Lys Single submitter ⚠
- p.His36Arg Single submitter ⚠
- p.Ile246Val Single submitter ⚠
- p.Leu14Phe Single submitter ⚠
- p.Leu169Pro Single submitter ⚠
- p.Lys260Arg Single submitter ⚠
- p.Lys41Gln Single submitter ⚠
- p.Phe48Leu Single submitter ⚠
- p.Pro459Ser Single submitter ⚠
- p.Ser96Gly Single submitter ⚠
- p.Thr135Met Single submitter ⚠
- p.Thr386Ala Single submitter ⚠
- p.Thr441Ala Single submitter ⚠
- p.Tyr32Phe Single submitter ⚠
- p.Tyr7Cys Single submitter ⚠
- p.Tyr7Ter Single submitter
- p.Tyr82Cys Single submitter ⚠
- c.731-2A>G No assertion criteria MAPK10-related disorder
- p.Ser424Asn No assertion criteria prostate cancer ⚠