MAPK11 — 35 ClinVar variants
All ClinVar germline MAPK11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
1 Benign · 3 Likely benign · 31 Uncertain significance
Full MAPK11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MAPK11 p.Ala121Ser Uncertain significance Single submitter
- MAPK11 p.Ala304Ser Uncertain significance Single submitter
- MAPK11 p.Arg189Gln Uncertain significance Single submitter
- MAPK11 p.Arg332His Uncertain significance Single submitter
- MAPK11 p.Arg45Trp Uncertain significance Single submitter
- MAPK11 p.Asp161Asn Uncertain significance Single submitter
- MAPK11 p.Asp176Glu Uncertain significance Single submitter
- MAPK11 p.Cys162Arg Uncertain significance Single submitter
- MAPK11 p.Glu325Asp Uncertain significance Single submitter
- MAPK11 p.Glu336Asp Uncertain significance Single submitter
- MAPK11 p.Gly181Ser Uncertain significance Single submitter
- MAPK11 p.Ile362Val Uncertain significance Single submitter
- MAPK11 p.Met194Ile Uncertain significance Single submitter
- MAPK11 p.Met265Leu Uncertain significance Single submitter
- MAPK11 p.Pro354Ala Uncertain significance Single submitter
- MAPK11 p.Ser252Leu Uncertain significance Single submitter
- MAPK11 p.Val102Leu Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- MAPK11 p.Ala184Thr Uncertain significance Single submitter
- MAPK11 p.Asp313Ala Uncertain significance Single submitter
- MAPK11 p.Glu125Gln Uncertain significance Single submitter
- MAPK11 p.Ile282Thr Uncertain significance Single submitter
- MAPK11 p.Phe99Leu Uncertain significance Single submitter
- MAPK11 p.Pro224Ala Uncertain significance Single submitter
- MAPK11 p.Pro314Ser Uncertain significance Single submitter
- MAPK11 p.Pro350Ser Uncertain significance Single submitter
- MAPK11 p.Ser251Phe Uncertain significance Single submitter
- MAPK11 p.Thr257Ile Uncertain significance Single submitter
- MAPK11 p.Thr333Met Uncertain significance Single submitter
- MAPK11 p.Val345Leu Uncertain significance Single submitter
All MAPK11 variants
Benign 1
- c.611-7C>T Multiple submitters
Uncertain significance 31
- p.Ala121Ser Single submitter ⚠
- p.Ala184Thr Single submitter ⚠
- p.Ala304Ser Single submitter ⚠
- p.Arg189Gln Single submitter ⚠
- p.Arg332His Single submitter ⚠
- p.Arg45Trp Single submitter ⚠
- p.Asp161Asn Single submitter ⚠
- p.Asp176Glu Single submitter ⚠
- p.Asp313Ala Single submitter ⚠
- p.Cys162Arg Single submitter ⚠
- p.Glu125Gln Single submitter ⚠
- p.Glu325Asp Single submitter ⚠
- p.Glu336Asp Single submitter ⚠
- p.Gly181Ser Single submitter ⚠
- p.Ile282Thr Single submitter ⚠
- p.Ile362Val Single submitter ⚠
- p.Met194Ile Single submitter ⚠
- p.Met213Val Single submitter
- p.Met265Leu Single submitter ⚠
- p.Phe99Leu Single submitter ⚠
- p.Pro224Ala Single submitter ⚠
- p.Pro224Arg Single submitter
- p.Pro314Ser Single submitter ⚠
- p.Pro350Ser Single submitter ⚠
- p.Pro354Ala Single submitter ⚠
- p.Ser251Phe Single submitter ⚠
- p.Ser252Leu Single submitter ⚠
- p.Thr257Ile Single submitter ⚠
- p.Thr333Met Single submitter ⚠
- p.Val102Leu Single submitter ⚠
- p.Val345Leu Single submitter ⚠