MAPK12 — 64 ClinVar variants
All ClinVar germline MAPK12 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 59 flagged for review →
1 Conflicting · 1 Likely benign · 62 Uncertain significance
Full MAPK12 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 59
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 44
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MAPK12 p.Ala146Thr Uncertain significance Single submitter
- MAPK12 p.Ala175Val Uncertain significance Single submitter
- MAPK12 p.Ala296Thr Uncertain significance Single submitter
- MAPK12 p.Arg189Gln Uncertain significance Single submitter
- MAPK12 p.Arg189Trp Uncertain significance Single submitter
- MAPK12 p.Arg192Gln Uncertain significance Single submitter
- MAPK12 p.Arg192Trp Uncertain significance Single submitter
- MAPK12 p.Arg299Gln Uncertain significance Single submitter
- MAPK12 p.Arg60Pro Uncertain significance Single submitter
- MAPK12 p.Arg82Cys Uncertain significance Single submitter
- MAPK12 p.Arg82His Uncertain significance Single submitter
- MAPK12 p.Asp171Asn Uncertain significance Single submitter
- MAPK12 p.Asp256Asn Uncertain significance Single submitter
- MAPK12 p.Cys214Arg Uncertain significance Single submitter
- MAPK12 p.Gln131His Uncertain significance Single submitter
- MAPK12 p.Glu195Lys Uncertain significance Single submitter
- MAPK12 p.Glu312Lys Uncertain significance Single submitter
- MAPK12 p.Glu318Gly Uncertain significance Single submitter
- MAPK12 p.Glu347Gly Uncertain significance Single submitter
- MAPK12 p.Glu65Gln Uncertain significance Single submitter
- MAPK12 p.Glu74Asp Uncertain significance Single submitter
- MAPK12 p.Glu97Asp Uncertain significance Single submitter
- MAPK12 p.Gly140Arg Uncertain significance Single submitter
- MAPK12 p.Gly157Ala Uncertain significance Single submitter
- MAPK12 p.Gly157Ser Uncertain significance Single submitter
- MAPK12 p.Gly173Ser Uncertain significance Single submitter
- MAPK12 p.Ile169Asn Uncertain significance Single submitter
- MAPK12 p.Leu198Phe Uncertain significance Single submitter
- MAPK12 p.Lys69Met Uncertain significance Single submitter
- MAPK12 p.Met291Thr Uncertain significance Single submitter
- MAPK12 p.Phe172Ile Uncertain significance Single submitter
- MAPK12 p.Phe249Ser Uncertain significance Single submitter
- MAPK12 p.Pro354Thr Uncertain significance Single submitter
- MAPK12 p.Thr224Met Uncertain significance Single submitter
- MAPK12 p.Thr278Ile Uncertain significance Single submitter
- MAPK12 p.Thr317Met Uncertain significance Single submitter
- MAPK12 p.Thr344Ser Uncertain significance Single submitter
- MAPK12 p.Thr365Met Uncertain significance Single submitter
- MAPK12 p.Thr98Ala Uncertain significance Single submitter
- MAPK12 p.Trp200Ser Uncertain significance Single submitter
- MAPK12 p.Tyr261Cys Uncertain significance Single submitter
- MAPK12 p.Tyr326Cys Uncertain significance Single submitter
- MAPK12 p.Tyr326Phe Uncertain significance Single submitter
- MAPK12 p.Val333Ile Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- MAPK12 p.Arg252Trp Uncertain significance Single submitter
- MAPK12 p.Asp104Glu Uncertain significance Single submitter
- MAPK12 p.Asp319Tyr Uncertain significance Single submitter
- MAPK12 p.Asp327Ala Uncertain significance Single submitter
- MAPK12 p.Glu127Lys Uncertain significance Single submitter
- MAPK12 p.Gly148Ser Uncertain significance Single submitter
- MAPK12 p.His315Tyr Uncertain significance Single submitter
- MAPK12 p.Leu314Val Uncertain significance Single submitter
- MAPK12 p.Phe249Leu Uncertain significance Single submitter
- MAPK12 p.Phe67Leu Uncertain significance Single submitter
- MAPK12 p.Pro246Leu Uncertain significance Single submitter
- MAPK12 p.Pro309Leu Uncertain significance Single submitter
- MAPK12 p.Thr242Met Uncertain significance Single submitter
- MAPK12 p.Val241Met Uncertain significance Single submitter
All MAPK12 variants
Conflicting classifications of pathogenicity 1
- p.Pro61Leu Single submitter ⚠
Likely benign 1
- p.Arg202His Single submitter
Uncertain significance 62
- p.Ala146Thr Single submitter ⚠
- p.Ala175Val Single submitter ⚠
- p.Ala296Thr Single submitter ⚠
- p.Arg129Trp Single submitter
- p.Arg189Gln Single submitter ⚠
- p.Arg189Trp Single submitter ⚠
- p.Arg192Gln Single submitter ⚠
- p.Arg192Trp Single submitter ⚠
- p.Arg252Trp Single submitter ⚠
- p.Arg299Gln Single submitter ⚠
- p.Arg60Pro Single submitter ⚠
- p.Arg82Cys Single submitter ⚠
- p.Arg82His Single submitter ⚠
- p.Asp104Glu Single submitter ⚠
- p.Asp171Asn Single submitter ⚠
- p.Asp256Asn Single submitter ⚠
- p.Asp319Tyr Single submitter ⚠
- p.Asp327Ala Single submitter ⚠
- p.Cys214Arg Single submitter ⚠
- p.Gln131His Single submitter ⚠
- p.Glu123Val Single submitter
- p.Glu127Lys Single submitter ⚠
- p.Glu195Lys Single submitter ⚠
- p.Glu312Lys Single submitter ⚠
- p.Glu318Gly Single submitter ⚠
- p.Glu347Gly Single submitter ⚠
- p.Glu65Gln Single submitter ⚠
- p.Glu74Asp Single submitter ⚠
- p.Glu97Asp Single submitter ⚠
- p.Gly140Arg Single submitter ⚠
- p.Gly148Ser Single submitter ⚠
- p.Gly157Ala Single submitter ⚠
- p.Gly157Ser Single submitter ⚠
- p.Gly173Ser Single submitter ⚠
- p.His315Tyr Single submitter ⚠
- p.Ile169Asn Single submitter ⚠
- p.Leu198Phe Single submitter ⚠
- p.Leu314Val Single submitter ⚠
- p.Lys69Met Single submitter ⚠
- p.Met112Val Single submitter
- p.Met291Thr Single submitter ⚠
- p.Phe172Ile Single submitter ⚠
- p.Phe249Leu Single submitter ⚠
- p.Phe249Ser Single submitter ⚠
- p.Phe67Leu Single submitter ⚠
- p.Pro246Leu Single submitter ⚠
- p.Pro309Leu Single submitter ⚠
- p.Pro354Thr Single submitter ⚠
- p.Thr204Met Single submitter
- p.Thr224Met Single submitter ⚠
- p.Thr242Met Single submitter ⚠
- p.Thr278Ile Single submitter ⚠
- p.Thr317Met Single submitter ⚠
- p.Thr344Ser Single submitter ⚠
- p.Thr365Met Single submitter ⚠
- p.Thr98Ala Single submitter ⚠
- p.Trp200Ser Single submitter ⚠
- p.Tyr261Cys Single submitter ⚠
- p.Tyr326Cys Single submitter ⚠
- p.Tyr326Phe Single submitter ⚠
- p.Val241Met Single submitter ⚠
- p.Val333Ile Single submitter ⚠