MAPK13 — 54 ClinVar variants
All ClinVar germline MAPK13 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 49 flagged for review →
3 Benign · 2 Likely benign · 49 Uncertain significance
Full MAPK13 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 49
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 38
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MAPK13 p.Ala281Gly Uncertain significance Single submitter
- MAPK13 p.Ala302Thr Uncertain significance Single submitter
- MAPK13 p.Ala320Ser Uncertain significance Single submitter
- MAPK13 p.Arg276Trp Uncertain significance Single submitter
- MAPK13 p.Arg296His Uncertain significance Single submitter
- MAPK13 p.Arg354Gln Uncertain significance Single submitter
- MAPK13 p.Arg358Trp Uncertain significance Single submitter
- MAPK13 p.Asn155Ser Uncertain significance Single submitter
- MAPK13 p.Asp252Asn Uncertain significance Single submitter
- MAPK13 p.Cys211Tyr Uncertain significance Single submitter
- MAPK13 p.Gln111His Uncertain significance Single submitter
- MAPK13 p.Gln231His Uncertain significance Single submitter
- MAPK13 p.Glu192Lys Uncertain significance Single submitter
- MAPK13 p.Gly154Ser Uncertain significance Single submitter
- MAPK13 p.Gly170Arg Uncertain significance Single submitter
- MAPK13 p.Gly210Ser Uncertain significance Single submitter
- MAPK13 p.Gly34Trp Uncertain significance Single submitter
- MAPK13 p.Gly362Asp Uncertain significance Single submitter
- MAPK13 p.Gly362Ser Uncertain significance Single submitter
- MAPK13 p.His330Gln Uncertain significance Single submitter
- MAPK13 p.Ile346Met Uncertain significance Single submitter
- MAPK13 p.Ile352Thr Uncertain significance Single submitter
- MAPK13 p.Leu105Pro Uncertain significance Single submitter
- MAPK13 p.Leu291Arg Uncertain significance Single submitter
- MAPK13 p.Leu87Phe Uncertain significance Single submitter
- MAPK13 p.Lys116Arg Uncertain significance Single submitter
- MAPK13 p.Met134Thr Uncertain significance Single submitter
- MAPK13 p.Met288Leu Uncertain significance Single submitter
- MAPK13 p.Met79Thr Uncertain significance Single submitter
- MAPK13 p.Pro310Arg Uncertain significance Single submitter
- MAPK13 p.Pro310His Uncertain significance Single submitter
- MAPK13 p.Pro310Leu Uncertain significance Single submitter
- MAPK13 p.Pro314Ala Uncertain significance Single submitter
- MAPK13 p.Ser95Ala Uncertain significance Single submitter
- MAPK13 p.Val147Met Uncertain significance Single submitter
- MAPK13 p.Val26Ala Uncertain significance Single submitter
- MAPK13 p.Val293Met Uncertain significance Single submitter
- MAPK13 p.Val39Met Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- MAPK13 p.Arg354Trp Uncertain significance Single submitter
- MAPK13 p.Glu125Lys Uncertain significance Single submitter
- MAPK13 p.Glu63Gly Uncertain significance Single submitter
- MAPK13 p.Leu135Phe Uncertain significance Single submitter
- MAPK13 p.Pro93Ser Uncertain significance Single submitter
- MAPK13 p.Ser327Tyr Uncertain significance Single submitter
- MAPK13 p.Ser41Leu Benign Single submitter
- MAPK13 p.Thr112Met Uncertain significance Single submitter
- MAPK13 p.Tyr343His Uncertain significance Single submitter
- MAPK13 p.Val158Met Uncertain significance Single submitter
- MAPK13 p.Val238Met Uncertain significance Single submitter
All MAPK13 variants
Benign 3
- c.496-3T>C Single submitter
- p.Ser41Leu Single submitter ⚠
- p.Thr112= Single submitter
Likely benign 2
- p.Ala281= Single submitter
- p.Asn251Lys Single submitter
Uncertain significance 49
- p.Ala281Gly Single submitter ⚠
- p.Ala302Thr Single submitter ⚠
- p.Ala320Ser Single submitter ⚠
- p.Arg276Trp Single submitter ⚠
- p.Arg296His Single submitter ⚠
- p.Arg354Gln Single submitter ⚠
- p.Arg354Trp Single submitter ⚠
- p.Arg358Trp Single submitter ⚠
- p.Asn155Ser Single submitter ⚠
- p.Asp252Asn Single submitter ⚠
- p.Cys211Tyr Single submitter ⚠
- p.Gln111His Single submitter ⚠
- p.Gln231His Single submitter ⚠
- p.Glu125Lys Single submitter ⚠
- p.Glu192Lys Single submitter ⚠
- p.Glu63Gly Single submitter ⚠
- p.Gly154Ser Single submitter ⚠
- p.Gly170Arg Single submitter ⚠
- p.Gly210Ser Single submitter ⚠
- p.Gly34Trp Single submitter ⚠
- p.Gly362Asp Single submitter ⚠
- p.Gly362Ser Single submitter ⚠
- p.His330Gln Single submitter ⚠
- p.Ile346Met Single submitter ⚠
- p.Ile352Thr Single submitter ⚠
- p.Leu105Pro Single submitter ⚠
- p.Leu135Phe Single submitter ⚠
- p.Leu291Arg Single submitter ⚠
- p.Leu73Val Single submitter
- p.Leu87Phe Single submitter ⚠
- p.Lys116Arg Single submitter ⚠
- p.Met134Thr Single submitter ⚠
- p.Met288Leu Single submitter ⚠
- p.Met79Thr Single submitter ⚠
- p.Pro310Arg Single submitter ⚠
- p.Pro310His Single submitter ⚠
- p.Pro310Leu Single submitter ⚠
- p.Pro314Ala Single submitter ⚠
- p.Pro93Ser Single submitter ⚠
- p.Ser327Tyr Single submitter ⚠
- p.Ser95Ala Single submitter ⚠
- p.Thr112Met Single submitter ⚠
- p.Tyr343His Single submitter ⚠
- p.Val147Met Single submitter ⚠
- p.Val158Met Single submitter ⚠
- p.Val238Met Single submitter ⚠
- p.Val26Ala Single submitter ⚠
- p.Val293Met Single submitter ⚠
- p.Val39Met Single submitter ⚠