MAPK14 — 31 ClinVar variants
All ClinVar germline MAPK14 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 17 flagged for review →
1 Benign · 6 Likely benign · 24 Uncertain significance
Full MAPK14 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 17
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MAPK14 p.Ala304Val Uncertain significance Single submitter
- MAPK14 p.Ala41Thr Uncertain significance Single submitter
- MAPK14 p.Arg73Trp Uncertain significance Single submitter
- MAPK14 p.Asn100Ser Uncertain significance Single submitter
- MAPK14 p.Asp145Gly Uncertain significance Single submitter
- MAPK14 p.Asp343Asn Uncertain significance Single submitter
- MAPK14 p.Gln3Arg Uncertain significance Single submitter
- MAPK14 p.Glu215Lys Uncertain significance Single submitter
- MAPK14 p.Glu97Lys Uncertain significance Single submitter
- MAPK14 p.Gly47Arg Uncertain significance Single submitter
- MAPK14 p.Ile346Ser Uncertain significance Single submitter
- MAPK14 p.Met194Ile Uncertain significance Single submitter
- MAPK14 p.Pro322Ala Uncertain significance Single submitter
- MAPK14 p.Pro322Thr Uncertain significance Single submitter
- MAPK14 p.Pro352Thr Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All MAPK14 variants
Benign 1
- p.His312= Single submitter
Likely benign 6
Uncertain significance 24
- c.763-2308A>G Single submitter
- c.763-2312A>G Single submitter
- c.763-2316G>A Single submitter
- c.763-2341C>G Single submitter
- c.763-2356G>A Single submitter
- p.Ala304Val Single submitter ⚠
- p.Ala41Thr Single submitter ⚠
- p.Arg10Pro Single submitter ⚠
- p.Arg10Trp Single submitter ⚠
- p.Arg73Trp Single submitter ⚠
- p.Asn100Ser Single submitter ⚠
- p.Asp145Gly Single submitter ⚠
- p.Asp343Asn Single submitter ⚠
- p.Gln3Arg Single submitter ⚠
- p.Glu215Lys Single submitter ⚠
- p.Glu97Lys Single submitter ⚠
- p.Gly47Arg Single submitter ⚠
- p.His199Arg Single submitter
- p.Ile346Ser Single submitter ⚠
- p.Met194Ile Single submitter ⚠
- p.Met194Val Single submitter
- p.Pro322Ala Single submitter ⚠
- p.Pro322Thr Single submitter ⚠
- p.Pro352Thr Single submitter ⚠