MAPK4 — 89 ClinVar variants
All ClinVar germline MAPK4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 85 flagged for review →
4 Likely benign · 85 Uncertain significance
Full MAPK4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 85
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 67
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MAPK4 p.Ala2Ser Uncertain significance Single submitter
- MAPK4 p.Ala473Val Uncertain significance Single submitter
- MAPK4 p.Ala481Gly Uncertain significance Single submitter
- MAPK4 p.Ala487Asp Uncertain significance Single submitter
- MAPK4 p.Ala9Ser Uncertain significance Single submitter
- MAPK4 p.Arg272Ser Uncertain significance Single submitter
- MAPK4 p.Arg329Cys Uncertain significance Single submitter
- MAPK4 p.Arg371Gln Uncertain significance Single submitter
- MAPK4 p.Arg380Gly Uncertain significance Single submitter
- MAPK4 p.Arg41Trp Uncertain significance Single submitter
- MAPK4 p.Arg444His Uncertain significance Single submitter
- MAPK4 p.Arg517Leu Uncertain significance Single submitter
- MAPK4 p.Arg517Pro Uncertain significance Single submitter
- MAPK4 p.Arg545His Uncertain significance Single submitter
- MAPK4 p.Arg71His Uncertain significance Single submitter
- MAPK4 p.Asn282Lys Uncertain significance Single submitter
- MAPK4 p.Asn31Asp Uncertain significance Single submitter
- MAPK4 p.Asn349Ser Uncertain significance Single submitter
- MAPK4 p.Asn446Lys Uncertain significance Single submitter
- MAPK4 p.Asp423Asn Uncertain significance Single submitter
- MAPK4 p.Asp478Glu Uncertain significance Single submitter
- MAPK4 p.Asp512Asn Uncertain significance Single submitter
- MAPK4 p.Asp563His Uncertain significance Single submitter
- MAPK4 p.Asp75Glu Uncertain significance Single submitter
- MAPK4 p.Cys43Tyr Uncertain significance Single submitter
- MAPK4 p.Gln379Arg Uncertain significance Single submitter
- MAPK4 p.Glu250Asp Uncertain significance Single submitter
- MAPK4 p.Glu3Lys Uncertain significance Single submitter
- MAPK4 p.Gly17Asp Uncertain significance Single submitter
- MAPK4 p.Gly17Ser Uncertain significance Single submitter
- MAPK4 p.Gly183Val Uncertain significance Single submitter
- MAPK4 p.Gly231Val Uncertain significance Single submitter
- MAPK4 p.Gly524Ser Uncertain significance Single submitter
- MAPK4 p.Ile8Thr Uncertain significance Single submitter
- MAPK4 p.Ile8Val Uncertain significance Single submitter
- MAPK4 p.Leu476Pro Uncertain significance Single submitter
- MAPK4 p.Met130Val Uncertain significance Single submitter
- MAPK4 p.Pro471Ser Uncertain significance Single submitter
- MAPK4 p.Pro486Leu Uncertain significance Single submitter
- MAPK4 p.Pro509Gln Uncertain significance Single submitter
- MAPK4 p.Pro522Ala Uncertain significance Single submitter
- MAPK4 p.Pro522Leu Uncertain significance Single submitter
- MAPK4 p.Pro522Ser Uncertain significance Single submitter
- MAPK4 p.Pro523Leu Uncertain significance Single submitter
- MAPK4 p.Pro528Arg Uncertain significance Single submitter
- MAPK4 p.Pro528Leu Uncertain significance Single submitter
- MAPK4 p.Pro557Leu Uncertain significance Single submitter
- MAPK4 p.Ser262Phe Uncertain significance Single submitter
- MAPK4 p.Ser452Leu Uncertain significance Single submitter
- MAPK4 p.Ser508Thr Uncertain significance Single submitter
- MAPK4 p.Ser521Ala Uncertain significance Single submitter
- MAPK4 p.Ser521Leu Uncertain significance Single submitter
- MAPK4 p.Ser534Arg Uncertain significance Single submitter
- MAPK4 p.Ser99Arg Uncertain significance Single submitter
- MAPK4 p.Ser99Cys Uncertain significance Single submitter
- MAPK4 p.Thr479Arg Uncertain significance Single submitter
- MAPK4 p.Tyr14Cys Uncertain significance Single submitter
- MAPK4 p.Val104Ile Uncertain significance Single submitter
- MAPK4 p.Val145Met Uncertain significance Single submitter
- MAPK4 p.Val163Leu Uncertain significance Single submitter
- MAPK4 p.Val175Ile Uncertain significance Single submitter
- MAPK4 p.Val247Ile Uncertain significance Single submitter
- MAPK4 p.Val338Ala Uncertain significance Single submitter
- MAPK4 p.Val393Met Uncertain significance Single submitter
- MAPK4 p.Val529Ala Uncertain significance Single submitter
- MAPK4 p.Val541Met Uncertain significance Single submitter
- MAPK4 p.Val78Ile Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- MAPK4 p.Arg195Cys Uncertain significance Single submitter
- MAPK4 p.Arg198Leu Uncertain significance Single submitter
- MAPK4 p.Arg19His Uncertain significance Single submitter
- MAPK4 p.Asp111Asn Uncertain significance Single submitter
- MAPK4 p.Cys317Tyr Uncertain significance Single submitter
- MAPK4 p.Glu255Lys Uncertain significance Single submitter
- MAPK4 p.Gly119Asp Uncertain significance Single submitter
- MAPK4 p.His233Gln Uncertain significance Single submitter
- MAPK4 p.Ile493Thr Uncertain significance Single submitter
- MAPK4 p.Leu171Ser Uncertain significance Single submitter
- MAPK4 p.Lys138Gln Uncertain significance Single submitter
- MAPK4 p.Lys60Gln Uncertain significance Single submitter
- MAPK4 p.Met212Ile Uncertain significance Single submitter
- MAPK4 p.Met238Ile Uncertain significance Single submitter
- MAPK4 p.Met312Ile Uncertain significance Single submitter
- MAPK4 p.Met340Ile Uncertain significance Single submitter
- MAPK4 p.Ser360Arg Uncertain significance Single submitter
- MAPK4 p.Ser436Phe Uncertain significance Single submitter
All MAPK4 variants
Likely benign 4
- c.692-4C>T Single submitter
- p.Glu234= Single submitter
- p.His61= Single submitter
- p.Thr479Ala Single submitter
Uncertain significance 85
- p.Ala2Ser Single submitter ⚠
- p.Ala473Val Single submitter ⚠
- p.Ala481Gly Single submitter ⚠
- p.Ala487Asp Single submitter ⚠
- p.Ala9Ser Single submitter ⚠
- p.Arg195Cys Single submitter ⚠
- p.Arg198Leu Single submitter ⚠
- p.Arg19His Single submitter ⚠
- p.Arg272Ser Single submitter ⚠
- p.Arg329Cys Single submitter ⚠
- p.Arg371Gln Single submitter ⚠
- p.Arg380Gly Single submitter ⚠
- p.Arg41Trp Single submitter ⚠
- p.Arg444His Single submitter ⚠
- p.Arg517Leu Single submitter ⚠
- p.Arg517Pro Single submitter ⚠
- p.Arg545His Single submitter ⚠
- p.Arg71His Single submitter ⚠
- p.Asn282Lys Single submitter ⚠
- p.Asn31Asp Single submitter ⚠
- p.Asn349Ser Single submitter ⚠
- p.Asn446Lys Single submitter ⚠
- p.Asp111Asn Single submitter ⚠
- p.Asp423Asn Single submitter ⚠
- p.Asp478Glu Single submitter ⚠
- p.Asp512Asn Single submitter ⚠
- p.Asp563His Single submitter ⚠
- p.Asp75Glu Single submitter ⚠
- p.Cys317Tyr Single submitter ⚠
- p.Cys43Tyr Single submitter ⚠
- p.Gln379Arg Single submitter ⚠
- p.Glu250Asp Single submitter ⚠
- p.Glu255Lys Single submitter ⚠
- p.Glu3Lys Single submitter ⚠
- p.Gly119Asp Single submitter ⚠
- p.Gly17Asp Single submitter ⚠
- p.Gly17Ser Single submitter ⚠
- p.Gly183Val Single submitter ⚠
- p.Gly231Val Single submitter ⚠
- p.Gly524Ser Single submitter ⚠
- p.His233Gln Single submitter ⚠
- p.Ile493Thr Single submitter ⚠
- p.Ile8Thr Single submitter ⚠
- p.Ile8Val Single submitter ⚠
- p.Leu171Ser Single submitter ⚠
- p.Leu476Pro Single submitter ⚠
- p.Lys138Gln Single submitter ⚠
- p.Lys60Gln Single submitter ⚠
- p.Met130Val Single submitter ⚠
- p.Met212Ile Single submitter ⚠
- p.Met238Ile Single submitter ⚠
- p.Met312Ile Single submitter ⚠
- p.Met340Ile Single submitter ⚠
- p.Pro471Ser Single submitter ⚠
- p.Pro486Leu Single submitter ⚠
- p.Pro509Gln Single submitter ⚠
- p.Pro522Ala Single submitter ⚠
- p.Pro522Leu Single submitter ⚠
- p.Pro522Ser Single submitter ⚠
- p.Pro523Leu Single submitter ⚠
- p.Pro528Arg Single submitter ⚠
- p.Pro528Leu Single submitter ⚠
- p.Pro557Leu Single submitter ⚠
- p.Ser262Phe Single submitter ⚠
- p.Ser360Arg Single submitter ⚠
- p.Ser436Phe Single submitter ⚠
- p.Ser452Leu Single submitter ⚠
- p.Ser508Thr Single submitter ⚠
- p.Ser521Ala Single submitter ⚠
- p.Ser521Leu Single submitter ⚠
- p.Ser534Arg Single submitter ⚠
- p.Ser99Arg Single submitter ⚠
- p.Ser99Cys Single submitter ⚠
- p.Thr479Arg Single submitter ⚠
- p.Tyr14Cys Single submitter ⚠
- p.Val104Ile Single submitter ⚠
- p.Val145Met Single submitter ⚠
- p.Val163Leu Single submitter ⚠
- p.Val175Ile Single submitter ⚠
- p.Val247Ile Single submitter ⚠
- p.Val338Ala Single submitter ⚠
- p.Val393Met Single submitter ⚠
- p.Val529Ala Single submitter ⚠
- p.Val541Met Single submitter ⚠
- p.Val78Ile Single submitter ⚠