MAPK6 — 71 ClinVar variants
All ClinVar germline MAPK6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 69 flagged for review →
1 Likely benign · 70 Uncertain significance
Full MAPK6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 69
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 59
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MAPK6 p.Ala218Gly Uncertain significance Single submitter
- MAPK6 p.Ala515Gly Uncertain significance Single submitter
- MAPK6 p.Ala515Ser Uncertain significance Single submitter
- MAPK6 p.Ala695Thr Uncertain significance Single submitter
- MAPK6 p.Arg256His Uncertain significance Single submitter
- MAPK6 p.Arg406Gln Uncertain significance Single submitter
- MAPK6 p.Arg406Trp Uncertain significance Single submitter
- MAPK6 p.Arg449Lys Uncertain significance Single submitter
- MAPK6 p.Arg635Lys Uncertain significance Single submitter
- MAPK6 p.Arg655Lys Uncertain significance Single submitter
- MAPK6 p.Asn31Ser Uncertain significance Single submitter
- MAPK6 p.Asp405Gly Uncertain significance Single submitter
- MAPK6 p.Asp416Ala Uncertain significance Single submitter
- MAPK6 p.Asp545Asn Uncertain significance Single submitter
- MAPK6 p.Cys360Ser Uncertain significance Single submitter
- MAPK6 p.Gln504His Uncertain significance Single submitter
- MAPK6 p.Gln572Lys Uncertain significance Single submitter
- MAPK6 p.Gln681His Uncertain significance Single submitter
- MAPK6 p.Glu246Gln Uncertain significance Single submitter
- MAPK6 p.Glu309Ala Uncertain significance Single submitter
- MAPK6 p.Glu377Lys Uncertain significance Single submitter
- MAPK6 p.Glu439Asp Uncertain significance Single submitter
- MAPK6 p.Glu643Gly Uncertain significance Single submitter
- MAPK6 p.Glu654Gly Uncertain significance Single submitter
- MAPK6 p.Gly228Ala Uncertain significance Single submitter
- MAPK6 p.Gly29Arg Uncertain significance Single submitter
- MAPK6 p.Gly516Arg Uncertain significance Single submitter
- MAPK6 p.Gly600Asp Uncertain significance Single submitter
- MAPK6 p.Gly653Arg Uncertain significance Single submitter
- MAPK6 p.His541Asp Uncertain significance Single submitter
- MAPK6 p.His657Arg Uncertain significance Single submitter
- MAPK6 p.His683Asn Uncertain significance Single submitter
- MAPK6 p.Ile160Val Uncertain significance Single submitter
- MAPK6 p.Ile169Thr Uncertain significance Single submitter
- MAPK6 p.Ile351Val Uncertain significance Single submitter
- MAPK6 p.Ile77Val Uncertain significance Single submitter
- MAPK6 p.Leu260Val Uncertain significance Single submitter
- MAPK6 p.Leu537Val Uncertain significance Single submitter
- MAPK6 p.Leu652Pro Uncertain significance Single submitter
- MAPK6 p.Leu662Val Uncertain significance Single submitter
- MAPK6 p.Leu72Val Uncertain significance Single submitter
- MAPK6 p.Phe610Ser Uncertain significance Single submitter
- MAPK6 p.Pro413His Uncertain significance Single submitter
- MAPK6 p.Pro423Ala Uncertain significance Single submitter
- MAPK6 p.Pro706Leu Uncertain significance Single submitter
- MAPK6 p.Ser261Arg Uncertain significance Single submitter
- MAPK6 p.Ser441Gly Uncertain significance Single submitter
- MAPK6 p.Ser450Ala Uncertain significance Single submitter
- MAPK6 p.Ser571Arg Uncertain significance Single submitter
- MAPK6 p.Ser704Tyr Uncertain significance Single submitter
- MAPK6 p.Ser714Asn Uncertain significance Single submitter
- MAPK6 p.Thr227Ile Uncertain significance Single submitter
- MAPK6 p.Thr389Ile Uncertain significance Single submitter
- MAPK6 p.Thr448Lys Uncertain significance Single submitter
- MAPK6 p.Thr624Ser Uncertain significance Single submitter
- MAPK6 p.Thr92Ala Uncertain significance Single submitter
- MAPK6 p.Tyr589His Uncertain significance Single submitter
- MAPK6 p.Val251Ile Uncertain significance Single submitter
- MAPK6 p.Val647Gly Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- MAPK6 p.Asp345Gly Uncertain significance Single submitter
- MAPK6 p.Ile716Ser Uncertain significance Single submitter
- MAPK6 p.Met225Leu Uncertain significance Single submitter
- MAPK6 p.Met271Ile Uncertain significance Single submitter
- MAPK6 p.Met344Thr Uncertain significance Single submitter
- MAPK6 p.Phe159Leu Uncertain significance Single submitter
- MAPK6 p.Pro398Ala Uncertain significance Single submitter
- MAPK6 p.Ser538Arg Uncertain significance Single submitter
- MAPK6 p.Ser715Arg Uncertain significance Single submitter
- MAPK6 p.Thr230Ile Uncertain significance Single submitter
All MAPK6 variants
Likely benign 1
- p.Asn418Ser Single submitter
Uncertain significance 70
- p.Ala218Gly Single submitter ⚠
- p.Ala515Gly Single submitter ⚠
- p.Ala515Ser Single submitter ⚠
- p.Ala695Thr Single submitter ⚠
- p.Arg256His Single submitter ⚠
- p.Arg406Gln Single submitter ⚠
- p.Arg406Trp Single submitter ⚠
- p.Arg449Lys Single submitter ⚠
- p.Arg635Lys Single submitter ⚠
- p.Arg655Lys Single submitter ⚠
- p.Asn31Ser Single submitter ⚠
- p.Asp345Gly Single submitter ⚠
- p.Asp405Gly Single submitter ⚠
- p.Asp416Ala Single submitter ⚠
- p.Asp545Asn Single submitter ⚠
- p.Cys360Ser Single submitter ⚠
- p.Gln504His Single submitter ⚠
- p.Gln572Lys Single submitter ⚠
- p.Gln681His Single submitter ⚠
- p.Glu246Gln Single submitter ⚠
- p.Glu309Ala Single submitter ⚠
- p.Glu377Lys Single submitter ⚠
- p.Glu439Asp Single submitter ⚠
- p.Glu643Gly Single submitter ⚠
- p.Glu654Gly Single submitter ⚠
- p.Gly228Ala Single submitter ⚠
- p.Gly29Arg Single submitter ⚠
- p.Gly516Arg Single submitter ⚠
- p.Gly600Asp Single submitter ⚠
- p.Gly653Arg Single submitter ⚠
- p.His541Asp Single submitter ⚠
- p.His657Arg Single submitter ⚠
- p.His683Asn Single submitter ⚠
- p.Ile160Val Single submitter ⚠
- p.Ile169Thr Single submitter ⚠
- p.Ile351Val Single submitter ⚠
- p.Ile716Ser Single submitter ⚠
- p.Ile77Val Single submitter ⚠
- p.Leu260Val Single submitter ⚠
- p.Leu537Val Single submitter ⚠
- p.Leu652Pro Single submitter ⚠
- p.Leu662Val Single submitter ⚠
- p.Leu72Val Single submitter ⚠
- p.Met225Leu Single submitter ⚠
- p.Met271Ile Single submitter ⚠
- p.Met344Thr Single submitter ⚠
- p.Phe159Leu Single submitter ⚠
- p.Phe610Ser Single submitter ⚠
- p.Pro398Ala Single submitter ⚠
- p.Pro413His Single submitter ⚠
- p.Pro423Ala Single submitter ⚠
- p.Pro706Leu Single submitter ⚠
- p.Ser261Arg Single submitter ⚠
- p.Ser441Gly Single submitter ⚠
- p.Ser450Ala Single submitter ⚠
- p.Ser538Arg Single submitter ⚠
- p.Ser538Asn Single submitter
- p.Ser571Arg Single submitter ⚠
- p.Ser704Tyr Single submitter ⚠
- p.Ser714Asn Single submitter ⚠
- p.Ser715Arg Single submitter ⚠
- p.Thr227Ile Single submitter ⚠
- p.Thr230Ile Single submitter ⚠
- p.Thr389Ile Single submitter ⚠
- p.Thr448Lys Single submitter ⚠
- p.Thr624Ser Single submitter ⚠
- p.Thr92Ala Single submitter ⚠
- p.Tyr589His Single submitter ⚠
- p.Val251Ile Single submitter ⚠
- p.Val647Gly Single submitter ⚠