MAPK7 — 119 ClinVar variants
All ClinVar germline MAPK7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 110 flagged for review →
3 Pathogenic · 1 Benign/Likely benign · 4 Likely benign · 111 Uncertain significance
Full MAPK7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 110
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors vs ClinVar 3
ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.
-
MAPK7 p.Ala296Thr
Pathogenic
No assertion criteria
scoliosis, isolated, susceptibility to, 1
-
MAPK7 p.Pro587Leu
Pathogenic
No assertion criteria
scoliosis, isolated, susceptibility to, 1
-
MAPK7 p.Pro648Leu
Pathogenic
No assertion criteria
scoliosis, isolated, susceptibility to, 1
Predictors lean, ClinVar uncertain 83
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MAPK7 p.Ala288Ser Uncertain significance Single submitter
- MAPK7 p.Ala29Gly Uncertain significance Single submitter
- MAPK7 p.Ala334Thr Uncertain significance Single submitter
- MAPK7 p.Ala348Ser Uncertain significance Single submitter
- MAPK7 p.Ala360Val Uncertain significance Single submitter
- MAPK7 p.Ala481Ser Uncertain significance Single submitter
- MAPK7 p.Ala497Val Uncertain significance Single submitter
- MAPK7 p.Ala501Val Uncertain significance Single submitter
- MAPK7 p.Ala579Thr Uncertain significance Single submitter
- MAPK7 p.Ala579Val Uncertain significance Single submitter
- MAPK7 p.Ala582Gly Uncertain significance Single submitter
- MAPK7 p.Ala621Val Uncertain significance Single submitter
- MAPK7 p.Ala639Pro Uncertain significance Single submitter
- MAPK7 p.Ala653Thr Uncertain significance Single submitter
- MAPK7 p.Ala658Gly Uncertain significance Single submitter
- MAPK7 p.Ala696Thr Uncertain significance Single submitter
- MAPK7 p.Arg122Met Uncertain significance Single submitter
- MAPK7 p.Arg295Gln Uncertain significance Single submitter
- MAPK7 p.Arg304Cys Uncertain significance Single submitter
- MAPK7 p.Arg326His Uncertain significance Single submitter
- MAPK7 p.Arg329His Uncertain significance Single submitter
- MAPK7 p.Arg369His Uncertain significance Single submitter
- MAPK7 p.Arg396His Uncertain significance Single submitter
- MAPK7 p.Arg505Gln Uncertain significance Single submitter
- MAPK7 p.Arg535Gln Uncertain significance Single submitter
- MAPK7 p.Arg538Gln Uncertain significance Single submitter
- MAPK7 p.Arg797His Uncertain significance Single submitter
- MAPK7 p.Arg797Ser Uncertain significance Single submitter
- MAPK7 p.Asp12Asn Uncertain significance Single submitter
- MAPK7 p.Asp358Asn Uncertain significance Single submitter
- MAPK7 p.Asp358His Uncertain significance Single submitter
- MAPK7 p.Asp364Glu Uncertain significance Single submitter
- MAPK7 p.Asp428Asn Uncertain significance Single submitter
- MAPK7 p.Asp761Asn Uncertain significance Single submitter
- MAPK7 p.Gln402Arg Uncertain significance Single submitter
- MAPK7 p.Gln511Arg Uncertain significance Single submitter
- MAPK7 p.Gln619Lys Uncertain significance Single submitter
- MAPK7 p.Gln656Glu Uncertain significance Single submitter
- MAPK7 p.Glu783Gln Uncertain significance Single submitter
- MAPK7 p.Glu7Lys Uncertain significance Single submitter
- MAPK7 p.His180Pro Uncertain significance Single submitter
- MAPK7 p.His27Tyr Uncertain significance Single submitter
- MAPK7 p.Ile399Met Uncertain significance Single submitter
- MAPK7 p.Leu156Met Uncertain significance Single submitter
- MAPK7 p.Leu451Val Uncertain significance Single submitter
- MAPK7 p.Leu663Val Uncertain significance Single submitter
- MAPK7 p.Leu669Phe Uncertain significance Single submitter
- MAPK7 p.Lys265Arg Uncertain significance Single submitter
- MAPK7 p.Lys466Glu Uncertain significance Single submitter
- MAPK7 p.Met787Val Uncertain significance Single submitter
- MAPK7 p.Pro25Ser Uncertain significance Single submitter
- MAPK7 p.Pro303Thr Uncertain significance Single submitter
- MAPK7 p.Pro361Ser Uncertain significance Single submitter
- MAPK7 p.Pro407Ser Uncertain significance Single submitter
- MAPK7 p.Pro434Leu Uncertain significance Single submitter
- MAPK7 p.Pro438Leu Uncertain significance Single submitter
- MAPK7 p.Pro458Leu Uncertain significance Single submitter
- MAPK7 p.Pro602Ser Uncertain significance Single submitter
- MAPK7 p.Pro616Leu Uncertain significance Single submitter
- MAPK7 p.Pro631Leu Uncertain significance Single submitter
- MAPK7 p.Pro650Ser Uncertain significance Single submitter
- MAPK7 p.Pro692Leu Uncertain significance Single submitter
- MAPK7 p.Pro700Leu Uncertain significance Single submitter
- MAPK7 p.Pro725Ser Uncertain significance Single submitter
- MAPK7 p.Ser247Cys Uncertain significance Single submitter
- MAPK7 p.Ser31Phe Uncertain significance Single submitter
- MAPK7 p.Ser410Arg Uncertain significance Single submitter
- MAPK7 p.Ser410Asn Uncertain significance Single submitter
- MAPK7 p.Ser410Ile Uncertain significance Single submitter
- MAPK7 p.Ser421Gly Uncertain significance Single submitter
- MAPK7 p.Ser678Phe Uncertain significance Single submitter
- MAPK7 p.Ser703Ala Uncertain significance Single submitter
- MAPK7 p.Ser71Phe Uncertain significance Single submitter
- MAPK7 p.Ser754Cys Uncertain significance Single submitter
- MAPK7 p.Thr240Ile Uncertain significance Single submitter
- MAPK7 p.Thr452Ser Uncertain significance Single submitter
- MAPK7 p.Thr596Ile Uncertain significance Single submitter
- MAPK7 p.Thr659Ile Uncertain significance Single submitter
- MAPK7 p.Thr661Ile Uncertain significance Single submitter
- MAPK7 p.Tyr66Cys Uncertain significance Single submitter
- MAPK7 p.Val125Met Uncertain significance Single submitter
- MAPK7 p.Val285Met Uncertain significance Single submitter
- MAPK7 p.Val759Met Uncertain significance Single submitter
Predictors split 24
The independent predictors disagree with each other — read with care.
- MAPK7 p.Ala510Thr Uncertain significance Single submitter
- MAPK7 p.Ala592Glu Uncertain significance Single submitter
- MAPK7 p.Arg259Gly Uncertain significance Single submitter
- MAPK7 p.Arg369Cys Uncertain significance Single submitter
- MAPK7 p.Arg513His Uncertain significance Single submitter
- MAPK7 p.Arg517Trp Uncertain significance Single submitter
- MAPK7 p.Arg543Trp Uncertain significance Single submitter
- MAPK7 p.Arg74Cys Uncertain significance Single submitter
- MAPK7 p.Arg797Cys Uncertain significance Single submitter
- MAPK7 p.Glu518Asp Uncertain significance Single submitter
- MAPK7 p.Gly169Ala Uncertain significance Single submitter
- MAPK7 p.Ile117Met Uncertain significance Single submitter
- MAPK7 p.Ile57Thr Uncertain significance Single submitter
- MAPK7 p.Ile61Leu Uncertain significance Single submitter
- MAPK7 p.Leu121Pro Uncertain significance Single submitter
- MAPK7 p.Lys131Asn Uncertain significance Single submitter
- MAPK7 p.Met787Thr Uncertain significance Single submitter
- MAPK7 p.Phe217Ser Uncertain significance Single submitter
- MAPK7 p.Pro283Leu Uncertain significance Single submitter
- MAPK7 p.Pro602Arg Uncertain significance Single submitter
- MAPK7 p.Pro618Arg Uncertain significance Single submitter
- MAPK7 p.Pro636Arg Uncertain significance Single submitter
- MAPK7 p.Pro727Arg Uncertain significance Single submitter
- MAPK7 p.Tyr267Cys Uncertain significance Single submitter
All MAPK7 variants
Pathogenic 3
- p.Ala296Thr No assertion criteria scoliosis, isolated, susceptibility to, 1 ⚠
- p.Pro587Leu No assertion criteria scoliosis, isolated, susceptibility to, 1 ⚠
- p.Pro648Leu No assertion criteria scoliosis, isolated, susceptibility to, 1 ⚠
Benign/Likely benign 1
- p.Pro551Ser Multiple submitters
Likely benign 4
- p.Ala592Val Single submitter
- p.Arg577Gln Single submitter
- p.Pro211= Single submitter
- p.Val459= Single submitter
Uncertain significance 111
- p.Ala288Ser Single submitter ⚠
- p.Ala29Gly Single submitter ⚠
- p.Ala334Thr Single submitter ⚠
- p.Ala348Ser Single submitter ⚠
- p.Ala360Val Single submitter ⚠
- p.Ala481Ser Single submitter ⚠
- p.Ala497Val Single submitter ⚠
- p.Ala501Val Single submitter ⚠
- p.Ala510Thr Single submitter ⚠
- p.Ala579Thr Single submitter ⚠
- p.Ala579Val Single submitter ⚠
- p.Ala582Gly Single submitter ⚠
- p.Ala592Glu Single submitter ⚠
- p.Ala621Val Single submitter ⚠
- p.Ala639Pro Single submitter ⚠
- p.Ala653Thr Single submitter ⚠
- p.Ala658Gly Single submitter ⚠
- p.Ala696Thr Single submitter ⚠
- p.Arg122Met Single submitter ⚠
- p.Arg160Cys Single submitter
- p.Arg259Gly Single submitter ⚠
- p.Arg295Gln Single submitter ⚠
- p.Arg304Cys Single submitter ⚠
- p.Arg326His Single submitter ⚠
- p.Arg329His Single submitter ⚠
- p.Arg369Cys Single submitter ⚠
- p.Arg369His Single submitter ⚠
- p.Arg396His Single submitter ⚠
- p.Arg43Cys Single submitter
- p.Arg505Gln Single submitter ⚠
- p.Arg513His Single submitter ⚠
- p.Arg517Trp Single submitter ⚠
- p.Arg535Gln Single submitter ⚠
- p.Arg538Gln Single submitter ⚠
- p.Arg543Trp Single submitter ⚠
- p.Arg74Cys Single submitter ⚠
- p.Arg797Cys Single submitter ⚠
- p.Arg797His Single submitter ⚠
- p.Arg797Ser Single submitter ⚠
- p.Asp12Asn Single submitter ⚠
- p.Asp358Asn Single submitter ⚠
- p.Asp358His Single submitter ⚠
- p.Asp364Glu Single submitter ⚠
- p.Asp428Asn Single submitter ⚠
- p.Asp761Asn Single submitter ⚠
- p.Gln402Arg Single submitter ⚠
- p.Gln511Arg Single submitter ⚠
- p.Gln619Lys Single submitter ⚠
- p.Gln656Glu Single submitter ⚠
- p.Glu518Asp Single submitter ⚠
- p.Glu783Gln Single submitter ⚠
- p.Glu7Lys Single submitter ⚠
- p.Gly169Ala Single submitter ⚠
- p.His180Pro Single submitter ⚠
- p.His27Tyr Single submitter ⚠
- p.Ile117Met Single submitter ⚠
- p.Ile399Met Single submitter ⚠
- p.Ile57Thr Single submitter ⚠
- p.Ile61Leu Single submitter ⚠
- p.Leu121Pro Single submitter ⚠
- p.Leu156Met Single submitter ⚠
- p.Leu451Val Single submitter ⚠
- p.Leu663Val Single submitter ⚠
- p.Leu669Phe Single submitter ⚠
- p.Lys131Asn Single submitter ⚠
- p.Lys265Arg Single submitter ⚠
- p.Lys466Glu Single submitter ⚠
- p.Lys97Arg Single submitter
- p.Met787Thr Single submitter ⚠
- p.Met787Val Single submitter ⚠
- p.Phe217Ser Single submitter ⚠
- p.Phe730Tyr Single submitter
- p.Pro25Ser Single submitter ⚠
- p.Pro283Leu Single submitter ⚠
- p.Pro303Thr Single submitter ⚠
- p.Pro361Ser Single submitter ⚠
- p.Pro407Ser Single submitter ⚠
- p.Pro434Leu Single submitter ⚠
- p.Pro438Leu Single submitter ⚠
- p.Pro458Leu Single submitter ⚠
- p.Pro602Arg Single submitter ⚠
- p.Pro602Ser Single submitter ⚠
- p.Pro616Leu Single submitter ⚠
- p.Pro618Arg Single submitter ⚠
- p.Pro631Leu Single submitter ⚠
- p.Pro636Arg Single submitter ⚠
- p.Pro650Ser Single submitter ⚠
- p.Pro692Leu Single submitter ⚠
- p.Pro700Leu Single submitter ⚠
- p.Pro725Ser Single submitter ⚠
- p.Pro727Arg Single submitter ⚠
- p.Ser247Cys Single submitter ⚠
- p.Ser31Phe Single submitter ⚠
- p.Ser410Arg Single submitter ⚠
- p.Ser410Asn Single submitter ⚠
- p.Ser410Ile Single submitter ⚠
- p.Ser421Gly Single submitter ⚠
- p.Ser678Phe Single submitter ⚠
- p.Ser703Ala Single submitter ⚠
- p.Ser71Phe Single submitter ⚠
- p.Ser754Cys Single submitter ⚠
- p.Thr240Ile Single submitter ⚠
- p.Thr452Ser Single submitter ⚠
- p.Thr596Ile Single submitter ⚠
- p.Thr659Ile Single submitter ⚠
- p.Thr661Ile Single submitter ⚠
- p.Tyr267Cys Single submitter ⚠
- p.Tyr66Cys Single submitter ⚠
- p.Val125Met Single submitter ⚠
- p.Val285Met Single submitter ⚠
- p.Val759Met Single submitter ⚠