MAPK9 — 29 ClinVar variants
All ClinVar germline MAPK9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 26 flagged for review →
1 Likely benign · 28 Uncertain significance
Full MAPK9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 26
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MAPK9 p.Ala246Val Uncertain significance Single submitter
- MAPK9 p.Arg174Gly Uncertain significance Single submitter
- MAPK9 p.Arg25Cys Uncertain significance Single submitter
- MAPK9 p.Arg25His Uncertain significance Single submitter
- MAPK9 p.Arg424Pro Uncertain significance Single submitter
- MAPK9 p.Asn394Ser Uncertain significance Single submitter
- MAPK9 p.Asp287Glu Uncertain significance Single submitter
- MAPK9 p.Asp378Gly Uncertain significance Single submitter
- MAPK9 p.Asp414Asn Uncertain significance Single submitter
- MAPK9 p.Asp7Glu Uncertain significance Single submitter
- MAPK9 p.His143Tyr Uncertain significance Single submitter
- MAPK9 p.His318Asn Uncertain significance Single submitter
- MAPK9 p.His66Pro Uncertain significance Single submitter
- MAPK9 p.Ile32Thr Uncertain significance Single submitter
- MAPK9 p.Ile396Val Uncertain significance Single submitter
- MAPK9 p.Leu142Gln Uncertain significance Single submitter
- MAPK9 p.Lys270Arg Uncertain significance Single submitter
- MAPK9 p.Met181Val Uncertain significance Single submitter
- MAPK9 p.Ser18Leu Uncertain significance Single submitter
- MAPK9 p.Ser400Cys Uncertain significance Single submitter
- MAPK9 p.Thr404Met Uncertain significance Single submitter
- MAPK9 p.Thr417Met Uncertain significance Single submitter
- MAPK9 p.Val186Met Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All MAPK9 variants
Likely benign 1
- p.Pro376Thr Single submitter
Uncertain significance 28
- c.617-399G>A Single submitter
- p.Ala246Val Single submitter ⚠
- p.Arg174Gly Single submitter ⚠
- p.Arg25Cys Single submitter ⚠
- p.Arg25His Single submitter ⚠
- p.Arg424Pro Single submitter ⚠
- p.Asn262Lys Single submitter ⚠
- p.Asn394Ser Single submitter ⚠
- p.Asp287Glu Single submitter ⚠
- p.Asp378Gly Single submitter ⚠
- p.Asp414Asn Single submitter ⚠
- p.Asp7Glu Single submitter ⚠
- p.Gly49Arg Single submitter
- p.His143Tyr Single submitter ⚠
- p.His318Asn Single submitter ⚠
- p.His66Pro Single submitter ⚠
- p.Ile32Thr Single submitter ⚠
- p.Ile396Val Single submitter ⚠
- p.Leu142Gln Single submitter ⚠
- p.Lys270Arg Single submitter ⚠
- p.Lys290Arg Single submitter ⚠
- p.Met181Val Single submitter ⚠
- p.Pro327Leu Single submitter ⚠
- p.Ser18Leu Single submitter ⚠
- p.Ser400Cys Single submitter ⚠
- p.Thr404Met Single submitter ⚠
- p.Thr417Met Single submitter ⚠
- p.Val186Met Single submitter ⚠