MARK4 — 98 ClinVar variants
All ClinVar germline MARK4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 81 flagged for review →
3 Benign · 4 Likely benign · 91 Uncertain significance
Full MARK4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 81
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 69
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MARK4 p.Ala168Ser Uncertain significance Single submitter
- MARK4 p.Ala389Val Uncertain significance Single submitter
- MARK4 p.Ala457Val Uncertain significance Single submitter
- MARK4 p.Ala462Val Uncertain significance Single submitter
- MARK4 p.Ala479Thr Uncertain significance Single submitter
- MARK4 p.Ala47Thr Uncertain significance Single submitter
- MARK4 p.Ala485Ser Uncertain significance Single submitter
- MARK4 p.Ala520Pro Uncertain significance Single submitter
- MARK4 p.Ala628Gly Uncertain significance Single submitter
- MARK4 p.Ala684Thr Uncertain significance Single submitter
- MARK4 p.Arg377Trp Uncertain significance Single submitter
- MARK4 p.Arg410Gln Uncertain significance Single submitter
- MARK4 p.Arg421Gly Uncertain significance Single submitter
- MARK4 p.Arg43Gln Uncertain significance Single submitter
- MARK4 p.Arg451Gln Uncertain significance Single submitter
- MARK4 p.Arg517His Uncertain significance Single submitter
- MARK4 p.Arg522Cys Uncertain significance Single submitter
- MARK4 p.Arg538Trp Uncertain significance Single submitter
- MARK4 p.Arg556Gln Uncertain significance Single submitter
- MARK4 p.Arg577Trp Uncertain significance Single submitter
- MARK4 p.Arg578Trp Uncertain significance Single submitter
- MARK4 p.Arg608Gln Uncertain significance Single submitter
- MARK4 p.Arg610His Uncertain significance Single submitter
- MARK4 p.Arg678His Uncertain significance Single submitter
- MARK4 p.Arg678Leu Uncertain significance Single submitter
- MARK4 p.Arg725Gln Uncertain significance Single submitter
- MARK4 p.Arg740His Uncertain significance Single submitter
- MARK4 p.Arg745His Uncertain significance Single submitter
- MARK4 p.Asn614His Uncertain significance Single submitter
- MARK4 p.Asn69Thr Uncertain significance Single submitter
- MARK4 p.Asn748His Uncertain significance Single submitter
- MARK4 p.Asn748Ser Uncertain significance Single submitter
- MARK4 p.Asp749Asn Uncertain significance Single submitter
- MARK4 p.Glu347Asp Uncertain significance Single submitter
- MARK4 p.Glu715Ala Uncertain significance Single submitter
- MARK4 p.Gly378Ser Uncertain significance Single submitter
- MARK4 p.Gly39Ser Uncertain significance Single submitter
- MARK4 p.Gly562Ser Uncertain significance Single submitter
- MARK4 p.Gly572Ser Uncertain significance Single submitter
- MARK4 p.Gly607Arg Uncertain significance Single submitter
- MARK4 p.His434Tyr Uncertain significance Single submitter
- MARK4 p.His599Tyr Uncertain significance Single submitter
- MARK4 p.Ile177Thr Uncertain significance Single submitter
- MARK4 p.Ile286Val Uncertain significance Single submitter
- MARK4 p.Ile87Met Uncertain significance Single submitter
- MARK4 p.Leu95Gln Uncertain significance Single submitter
- MARK4 p.Lys492Arg Uncertain significance Single submitter
- MARK4 p.Phe122Ser Uncertain significance Single submitter
- MARK4 p.Pro235Leu Uncertain significance Single submitter
- MARK4 p.Pro432Leu Uncertain significance Single submitter
- MARK4 p.Pro488Ala Uncertain significance Single submitter
- MARK4 p.Pro523Leu Uncertain significance Single submitter
- MARK4 p.Pro527Ser Uncertain significance Single submitter
- MARK4 p.Pro537Ala Uncertain significance Single submitter
- MARK4 p.Pro551Ser Uncertain significance Single submitter
- MARK4 p.Pro552Gln Uncertain significance Single submitter
- MARK4 p.Pro609Ser Uncertain significance Single submitter
- MARK4 p.Ser149Leu Uncertain significance Single submitter
- MARK4 p.Ser26Phe Uncertain significance Single submitter
- MARK4 p.Ser26Thr Uncertain significance Single submitter
- MARK4 p.Ser429Phe Uncertain significance Single submitter
- MARK4 p.Ser438Thr Uncertain significance Single submitter
- MARK4 p.Ser99Gly Uncertain significance Single submitter
- MARK4 p.Thr207Ala Uncertain significance Single submitter
- MARK4 p.Thr440Met Uncertain significance Single submitter
- MARK4 p.Tyr137Asp Uncertain significance Single submitter
- MARK4 p.Val339Met Uncertain significance Single submitter
- MARK4 p.Val587Met Uncertain significance Single submitter
- MARK4 p.Val743Ile Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- MARK4 p.Arg386Trp Uncertain significance Single submitter
- MARK4 p.Arg517Cys Uncertain significance Single submitter
- MARK4 p.Arg561His Uncertain significance Single submitter
- MARK4 p.Arg566Cys Uncertain significance Single submitter
- MARK4 p.Arg575Trp Uncertain significance Single submitter
- MARK4 p.Arg740Cys Uncertain significance Single submitter
- MARK4 p.Asp233Asn Uncertain significance Single submitter
- MARK4 p.Glu327Lys Uncertain significance Single submitter
- MARK4 p.Phe104Leu Uncertain significance Single submitter
- MARK4 p.Pro482Leu Uncertain significance Single submitter
- MARK4 p.Thr207Met Uncertain significance Single submitter
- MARK4 p.Thr344Lys Uncertain significance Single submitter
All MARK4 variants
Benign 3
- p.Leu226= Multiple submitters
- p.Thr461= Multiple submitters
- c.787-5T>C Single submitter
Likely benign 4
- p.Ala445Thr Single submitter
- p.Glu638= Single submitter
- p.Ile634= Single submitter
- p.Ile90= Single submitter
Uncertain significance 91
- c.1877+253dup Single submitter
- p.Ala168Ser Single submitter ⚠
- p.Ala389Val Single submitter ⚠
- p.Ala457Val Single submitter ⚠
- p.Ala462Val Single submitter ⚠
- p.Ala479Thr Single submitter ⚠
- p.Ala47Thr Single submitter ⚠
- p.Ala485Ser Single submitter ⚠
- p.Ala520Pro Single submitter ⚠
- p.Ala628Gly Single submitter ⚠
- p.Ala684Thr Single submitter ⚠
- p.Arg377Trp Single submitter ⚠
- p.Arg386Trp Single submitter ⚠
- p.Arg410Gln Single submitter ⚠
- p.Arg418His Single submitter
- p.Arg421Gly Single submitter ⚠
- p.Arg437Cys Single submitter
- p.Arg43Gln Single submitter ⚠
- p.Arg451Gln Single submitter ⚠
- p.Arg517Cys Single submitter ⚠
- p.Arg517His Single submitter ⚠
- p.Arg522Cys Single submitter ⚠
- p.Arg538Trp Single submitter ⚠
- p.Arg556Gln Single submitter ⚠
- p.Arg561His Single submitter ⚠
- p.Arg566Cys Single submitter ⚠
- p.Arg575Trp Single submitter ⚠
- p.Arg577Trp Single submitter ⚠
- p.Arg578Trp Single submitter ⚠
- p.Arg608Gln Single submitter ⚠
- p.Arg608Trp Single submitter
- p.Arg610His Single submitter ⚠
- p.Arg625Gln Single submitter
- p.Arg678His Single submitter ⚠
- p.Arg678Leu Single submitter ⚠
- p.Arg725Gln Single submitter ⚠
- p.Arg740Cys Single submitter ⚠
- p.Arg740His Single submitter ⚠
- p.Arg745His Single submitter ⚠
- p.Asn614His Single submitter ⚠
- p.Asn69Thr Single submitter ⚠
- p.Asn748His Single submitter ⚠
- p.Asn748Ser Single submitter ⚠
- p.Asp233Asn Single submitter ⚠
- p.Asp749Asn Single submitter ⚠
- p.Glu327Lys Single submitter ⚠
- p.Glu347Asp Single submitter ⚠
- p.Glu715Ala Single submitter ⚠
- p.Gly378Ser Single submitter ⚠
- p.Gly39Ser Single submitter ⚠
- p.Gly562Ser Single submitter ⚠
- p.Gly572Ser Single submitter ⚠
- p.Gly585= Single submitter
- p.Gly607Arg Single submitter ⚠
- p.His434Tyr Single submitter ⚠
- p.His599Tyr Single submitter ⚠
- p.Ile177Thr Single submitter ⚠
- p.Ile286Val Single submitter ⚠
- p.Ile87Met Single submitter ⚠
- p.Leu95Gln Single submitter ⚠
- p.Lys129fs Single submitter
- p.Lys175Gln Single submitter
- p.Lys492Arg Single submitter ⚠
- p.Phe104Leu Single submitter ⚠
- p.Phe122Ser Single submitter ⚠
- p.Pro235Leu Single submitter ⚠
- p.Pro432Leu Single submitter ⚠
- p.Pro471Arg Single submitter
- p.Pro482Leu Single submitter ⚠
- p.Pro488Ala Single submitter ⚠
- p.Pro523Leu Single submitter ⚠
- p.Pro527Ser Single submitter ⚠
- p.Pro537Ala Single submitter ⚠
- p.Pro551Ser Single submitter ⚠
- p.Pro552Gln Single submitter ⚠
- p.Pro609Ser Single submitter ⚠
- p.Ser149Leu Single submitter ⚠
- p.Ser167= Single submitter
- p.Ser26Phe Single submitter ⚠
- p.Ser26Thr Single submitter ⚠
- p.Ser429Phe Single submitter ⚠
- p.Ser438Thr Single submitter ⚠
- p.Ser99Gly Single submitter ⚠
- p.Thr207Ala Single submitter ⚠
- p.Thr207Met Single submitter ⚠
- p.Thr344Lys Single submitter ⚠
- p.Thr440Met Single submitter ⚠
- p.Tyr137Asp Single submitter ⚠
- p.Val339Met Single submitter ⚠
- p.Val587Met Single submitter ⚠
- p.Val743Ile Single submitter ⚠