Sugi Variant

Sugi Variant/MAST4

MAST4 — 371 ClinVar variants

All ClinVar germline MAST4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 304 flagged for review →

3 Likely pathogenic · 1 Conflicting · 6 Benign · 40 Likely benign · 321 Uncertain significance

Full MAST4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 304

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 256

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 256

Predictors split 46

The independent predictors disagree with each other — read with care.

All MAST4 variants

Likely pathogenic 3

Conflicting classifications of pathogenicity 1

Benign 6

Likely benign 40

Uncertain significance 321

Showing the top 300 by review status; the full set is in the sitemap.