MAT2B — 38 ClinVar variants
All ClinVar germline MAT2B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
1 Benign · 37 Uncertain significance
Full MAT2B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MAT2B p.Ala196Pro Uncertain significance Single submitter
- MAT2B p.Ala55Thr Uncertain significance Single submitter
- MAT2B p.Arg219Lys Uncertain significance Single submitter
- MAT2B p.Arg289His Uncertain significance Single submitter
- MAT2B p.Arg30Gly Uncertain significance Single submitter
- MAT2B p.Arg312Gln Uncertain significance Single submitter
- MAT2B p.Asn253Ser Uncertain significance Single submitter
- MAT2B p.Asn270Ser Uncertain significance Single submitter
- MAT2B p.Asn52Ser Uncertain significance Single submitter
- MAT2B p.Asp151Val Uncertain significance Single submitter
- MAT2B p.Gln294Arg Uncertain significance Single submitter
- MAT2B p.Glu21Lys Uncertain significance Single submitter
- MAT2B p.Glu260Asp Uncertain significance Single submitter
- MAT2B p.His54Leu Uncertain significance Single submitter
- MAT2B p.His83Asn Uncertain significance Single submitter
- MAT2B p.Ile10Met Uncertain significance Single submitter
- MAT2B p.Ile265Met Uncertain significance Single submitter
- MAT2B p.Ile26Leu Uncertain significance Single submitter
- MAT2B p.Ile305Val Uncertain significance Single submitter
- MAT2B p.Ile324Thr Uncertain significance Single submitter
- MAT2B p.Ile90Val Uncertain significance Single submitter
- MAT2B p.Lys161Arg Uncertain significance Single submitter
- MAT2B p.Lys191Thr Uncertain significance Single submitter
- MAT2B p.Met213Val Uncertain significance Single submitter
- MAT2B p.Ser251Ala Uncertain significance Single submitter
- MAT2B p.Ser9Phe Uncertain significance Single submitter
- MAT2B p.Thr229Ala Uncertain significance Single submitter
- MAT2B p.Thr331Met Uncertain significance Single submitter
- MAT2B p.Val56Phe Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- MAT2B p.Cys58Trp Uncertain significance Single submitter
- MAT2B p.Gln330His Uncertain significance Single submitter
- MAT2B p.Ile184Thr Uncertain significance Single submitter
- MAT2B p.Leu276Phe Uncertain significance Single submitter
- MAT2B p.Met200Thr Uncertain significance Single submitter
- MAT2B p.Val227Leu Uncertain significance Single submitter
All MAT2B variants
Benign 1
- p.Thr302Ile Single submitter
Uncertain significance 37
- p.Ala196Pro Single submitter ⚠
- p.Ala55Thr Single submitter ⚠
- p.Arg219Lys Single submitter ⚠
- p.Arg289His Single submitter ⚠
- p.Arg30Gly Single submitter ⚠
- p.Arg312Gln Single submitter ⚠
- p.Asn253Ser Single submitter ⚠
- p.Asn270Ser Single submitter ⚠
- p.Asn52Ser Single submitter ⚠
- p.Asp151Val Single submitter ⚠
- p.Cys58Trp Single submitter ⚠
- p.Gln294Arg Single submitter ⚠
- p.Gln330His Single submitter ⚠
- p.Glu21Lys Single submitter ⚠
- p.Glu260Asp Single submitter ⚠
- p.His54Leu Single submitter ⚠
- p.His83Asn Single submitter ⚠
- p.Ile10Met Single submitter ⚠
- p.Ile184Thr Single submitter ⚠
- p.Ile265Met Single submitter ⚠
- p.Ile26Leu Single submitter ⚠
- p.Ile305Val Single submitter ⚠
- p.Ile324Thr Single submitter ⚠
- p.Ile90Val Single submitter ⚠
- p.Leu276Phe Single submitter ⚠
- p.Lys161Arg Single submitter ⚠
- p.Lys191Thr Single submitter ⚠
- p.Met200Thr Single submitter ⚠
- p.Met213Val Single submitter ⚠
- p.Ser251Ala Single submitter ⚠
- p.Ser9Phe Single submitter ⚠
- p.Thr229Ala Single submitter ⚠
- p.Thr331Met Single submitter ⚠
- p.Tyr133Cys Single submitter
- p.Tyr138Phe Single submitter
- p.Val227Leu Single submitter ⚠
- p.Val56Phe Single submitter ⚠