MCHR2 — 45 ClinVar variants
All ClinVar germline MCHR2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 37 flagged for review →
2 Benign · 1 Likely benign · 42 Uncertain significance
Full MCHR2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 37
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MCHR2 p.Ala160Val Uncertain significance Single submitter
- MCHR2 p.Ala165Ser Uncertain significance Single submitter
- MCHR2 p.Ala234Asp Uncertain significance Single submitter
- MCHR2 p.Ala283Asp Uncertain significance Single submitter
- MCHR2 p.Arg140Gln Uncertain significance Single submitter
- MCHR2 p.Arg140Leu Uncertain significance Single submitter
- MCHR2 p.Arg143Cys Uncertain significance Single submitter
- MCHR2 p.Arg245Lys Uncertain significance Single submitter
- MCHR2 p.Arg63Gly Uncertain significance Single submitter
- MCHR2 p.Asn154Ser Uncertain significance Single submitter
- MCHR2 p.Asn331Ser Uncertain significance Single submitter
- MCHR2 p.Asp233His Uncertain significance Single submitter
- MCHR2 p.Gln276Glu Uncertain significance Single submitter
- MCHR2 p.Glu98Gln Uncertain significance Single submitter
- MCHR2 p.Gly287Cys Uncertain significance Single submitter
- MCHR2 p.Gly97Glu Uncertain significance Single submitter
- MCHR2 p.Ile109Val Uncertain significance Single submitter
- MCHR2 p.Ile123Val Uncertain significance Single submitter
- MCHR2 p.Ile292Val Uncertain significance Single submitter
- MCHR2 p.Ile320Thr Uncertain significance Single submitter
- MCHR2 p.Ile36Met Uncertain significance Single submitter
- MCHR2 p.Ile53Val Uncertain significance Single submitter
- MCHR2 p.Ile83Leu Uncertain significance Single submitter
- MCHR2 p.Leu272Pro Uncertain significance Single submitter
- MCHR2 p.Leu272Val Uncertain significance Single submitter
- MCHR2 p.Leu80Phe Uncertain significance Single submitter
- MCHR2 p.Phe162Ser Uncertain significance Single submitter
- MCHR2 p.Pro191Ala Uncertain significance Single submitter
- MCHR2 p.Ser183Ile Uncertain significance Single submitter
- MCHR2 p.Ser310Thr Uncertain significance Single submitter
- MCHR2 p.Thr11Ile Uncertain significance Single submitter
- MCHR2 p.Thr224Ile Uncertain significance Single submitter
- MCHR2 p.Trp20Leu Uncertain significance Single submitter
- MCHR2 p.Val50Ala Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All MCHR2 variants
Likely benign 1
- p.Leu135= Single submitter
Uncertain significance 42
- p.Ala160Val Single submitter ⚠
- p.Ala165Ser Single submitter ⚠
- p.Ala234Asp Single submitter ⚠
- p.Ala283Asp Single submitter ⚠
- p.Arg140Gln Single submitter ⚠
- p.Arg140Leu Single submitter ⚠
- p.Arg143Cys Single submitter ⚠
- p.Arg145Lys Single submitter
- p.Arg245Lys Single submitter ⚠
- p.Arg63Gly Single submitter ⚠
- p.Asn154Ser Single submitter ⚠
- p.Asn331Ser Single submitter ⚠
- p.Asp233His Single submitter ⚠
- p.Cys216Phe Single submitter
- p.Gln276Glu Single submitter ⚠
- p.Glu98Gln Single submitter ⚠
- p.Gly287Cys Single submitter ⚠
- p.Gly97Glu Single submitter ⚠
- p.His91Pro Single submitter
- p.Ile109Val Single submitter ⚠
- p.Ile123Val Single submitter ⚠
- p.Ile163Asn Single submitter ⚠
- p.Ile292Val Single submitter ⚠
- p.Ile320Thr Single submitter ⚠
- p.Ile36Met Single submitter ⚠
- p.Ile53Val Single submitter ⚠
- p.Ile83Leu Single submitter ⚠
- p.Leu135Phe Single submitter
- p.Leu272Pro Single submitter ⚠
- p.Leu272Val Single submitter ⚠
- p.Leu80Phe Single submitter ⚠
- p.Phe162Ser Single submitter ⚠
- p.Pro191Ala Single submitter ⚠
- p.Ser111Phe Single submitter ⚠
- p.Ser183Ile Single submitter ⚠
- p.Ser310Thr Single submitter ⚠
- p.Thr11Ile Single submitter ⚠
- p.Thr224Ile Single submitter ⚠
- p.Trp20Leu Single submitter ⚠
- p.Tyr267His Single submitter ⚠
- p.Val257Met Single submitter
- p.Val50Ala Single submitter ⚠