MCM3 — 126 ClinVar variants
All ClinVar germline MCM3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 114 flagged for review →
1 Benign · 2 Likely benign · 123 Uncertain significance
Full MCM3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 114
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 87
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MCM3 p.Ala278Thr Uncertain significance Single submitter
- MCM3 p.Ala300Gly Uncertain significance Single submitter
- MCM3 p.Ala509Val Uncertain significance Single submitter
- MCM3 p.Ala528Gly Uncertain significance Single submitter
- MCM3 p.Ala608Thr Uncertain significance Single submitter
- MCM3 p.Arg114Trp Uncertain significance Single submitter
- MCM3 p.Arg234Gln Uncertain significance Single submitter
- MCM3 p.Arg234Trp Uncertain significance Single submitter
- MCM3 p.Arg356Gln Uncertain significance Single submitter
- MCM3 p.Arg371Gln Uncertain significance Single submitter
- MCM3 p.Arg37Gln Uncertain significance Single submitter
- MCM3 p.Arg419His Uncertain significance Single submitter
- MCM3 p.Arg441Gln Uncertain significance Single submitter
- MCM3 p.Arg445His Uncertain significance Single submitter
- MCM3 p.Arg495Gln Uncertain significance Single submitter
- MCM3 p.Arg55His Uncertain significance Single submitter
- MCM3 p.Arg667Gln Uncertain significance Single submitter
- MCM3 p.Arg689Lys Uncertain significance Single submitter
- MCM3 p.Arg695Cys Uncertain significance Single submitter
- MCM3 p.Arg695His Uncertain significance Single submitter
- MCM3 p.Arg767Cys Uncertain significance Single submitter
- MCM3 p.Arg78Trp Uncertain significance Single submitter
- MCM3 p.Asn50Ser Uncertain significance Single submitter
- MCM3 p.Asn773Ser Uncertain significance Single submitter
- MCM3 p.Asp294Ala Uncertain significance Single submitter
- MCM3 p.Asp338Tyr Uncertain significance Single submitter
- MCM3 p.Asp42Gly Uncertain significance Single submitter
- MCM3 p.Asp541Asn Uncertain significance Single submitter
- MCM3 p.Asp601Gly Uncertain significance Single submitter
- MCM3 p.Asp676Gly Uncertain significance Single submitter
- MCM3 p.Asp684Glu Uncertain significance Single submitter
- MCM3 p.Asp753Gly Uncertain significance Single submitter
- MCM3 p.Asp795Glu Uncertain significance Single submitter
- MCM3 p.Cys119Arg Uncertain significance Single submitter
- MCM3 p.Cys126Phe Uncertain significance Single submitter
- MCM3 p.Gln77Leu Uncertain significance Single submitter
- MCM3 p.Glu180Asp Uncertain significance Single submitter
- MCM3 p.Glu669Lys Uncertain significance Single submitter
- MCM3 p.Glu778Asp Uncertain significance Single submitter
- MCM3 p.Gly211Ser Uncertain significance Single submitter
- MCM3 p.Gly345Val Uncertain significance Single submitter
- MCM3 p.Gly437Ser Uncertain significance Single submitter
- MCM3 p.His196Arg Uncertain significance Single submitter
- MCM3 p.Ile317Val Uncertain significance Single submitter
- MCM3 p.Ile422Thr Uncertain significance Single submitter
- MCM3 p.Ile526Thr Uncertain significance Single submitter
- MCM3 p.Leu102Pro Uncertain significance Single submitter
- MCM3 p.Leu190Phe Uncertain significance Single submitter
- MCM3 p.Leu225Phe Uncertain significance Single submitter
- MCM3 p.Leu299Arg Uncertain significance Single submitter
- MCM3 p.Leu482Val Uncertain significance Single submitter
- MCM3 p.Leu73Val Uncertain significance Single submitter
- MCM3 p.Lys289Glu Uncertain significance Single submitter
- MCM3 p.Lys570Met Uncertain significance Single submitter
- MCM3 p.Lys791Gln Uncertain significance Single submitter
- MCM3 p.Lys81Arg Uncertain significance Single submitter
- MCM3 p.Lys93Arg Uncertain significance Single submitter
- MCM3 p.Met466Val Uncertain significance Single submitter
- MCM3 p.Met518Val Uncertain significance Single submitter
- MCM3 p.Met562Ile Uncertain significance Single submitter
- MCM3 p.Met717Val Uncertain significance Single submitter
- MCM3 p.Met765Leu Uncertain significance Single submitter
- MCM3 p.Met799Ile Uncertain significance Single submitter
- MCM3 p.Phe256Leu Uncertain significance Single submitter
- MCM3 p.Phe76Tyr Uncertain significance Single submitter
- MCM3 p.Phe806Leu Uncertain significance Single submitter
- MCM3 p.Pro205Leu Uncertain significance Single submitter
- MCM3 p.Pro274Leu Uncertain significance Single submitter
- MCM3 p.Pro454Ser Uncertain significance Single submitter
- MCM3 p.Pro718Ser Uncertain significance Single submitter
- MCM3 p.Ser191Phe Uncertain significance Single submitter
- MCM3 p.Ser595Ala Uncertain significance Single submitter
- MCM3 p.Ser681Thr Uncertain significance Single submitter
- MCM3 p.Thr151Asn Uncertain significance Single submitter
- MCM3 p.Thr186Ile Uncertain significance Single submitter
- MCM3 p.Thr200Ser Uncertain significance Single submitter
- MCM3 p.Thr252Ala Uncertain significance Single submitter
- MCM3 p.Thr607Ala Uncertain significance Single submitter
- MCM3 p.Tyr147Asp Uncertain significance Single submitter
- MCM3 p.Tyr99Cys Uncertain significance Single submitter
- MCM3 p.Val100Leu Uncertain significance Single submitter
- MCM3 p.Val111Leu Uncertain significance Single submitter
- MCM3 p.Val219Ile Uncertain significance Single submitter
- MCM3 p.Val238Ala Uncertain significance Single submitter
- MCM3 p.Val448Leu Uncertain significance Single submitter
- MCM3 p.Val574Leu Uncertain significance Single submitter
- MCM3 p.Val74Ile Uncertain significance Single submitter
Predictors split 27
The independent predictors disagree with each other — read with care.
- MCM3 p.Ala262Ser Uncertain significance Single submitter
- MCM3 p.Arg138Cys Uncertain significance Single submitter
- MCM3 p.Arg143Cys Uncertain significance Single submitter
- MCM3 p.Arg158His Uncertain significance Single submitter
- MCM3 p.Arg403Gly Uncertain significance Single submitter
- MCM3 p.Arg596Cys Uncertain significance Single submitter
- MCM3 p.Arg664Ser Uncertain significance Single submitter
- MCM3 p.Asn181Lys Uncertain significance Single submitter
- MCM3 p.Asn58Lys Uncertain significance Single submitter
- MCM3 p.Asp280Glu Uncertain significance Single submitter
- MCM3 p.Asp82His Uncertain significance Single submitter
-
MCM3 p.Gln761Leu
Uncertain significance
Single submitter
Meier-Gorlin syndrome
- MCM3 p.Lys177Thr Uncertain significance Single submitter
- MCM3 p.Lys660Thr Uncertain significance Single submitter
- MCM3 p.Phe120Leu Uncertain significance Single submitter
- MCM3 p.Pro183Ser Uncertain significance Single submitter
- MCM3 p.Pro183Thr Uncertain significance Single submitter
- MCM3 p.Pro707Leu Uncertain significance Single submitter
- MCM3 p.Ser586Leu Uncertain significance Single submitter
- MCM3 p.Ser634Asn Uncertain significance Single submitter
- MCM3 p.Ser86Phe Uncertain significance Single submitter
- MCM3 p.Thr420Ala Uncertain significance Single submitter
- MCM3 p.Thr610Ile Uncertain significance Single submitter
- MCM3 p.Tyr188Cys Uncertain significance Single submitter
- MCM3 p.Tyr651Cys Uncertain significance Single submitter
- MCM3 p.Val217Leu Uncertain significance Single submitter
- MCM3 p.Val563Ala Uncertain significance Single submitter
All MCM3 variants
Benign 1
- c.771-10T>C Single submitter
Likely benign 2
- p.Ile805Val Single submitter
- p.Val783Ala Single submitter
Uncertain significance 123
- p.Ala262Ser Single submitter ⚠
- p.Ala278Thr Single submitter ⚠
- p.Ala300Gly Single submitter ⚠
- p.Ala509Val Single submitter ⚠
- p.Ala528Gly Single submitter ⚠
- p.Ala608Thr Single submitter ⚠
- p.Arg114Trp Single submitter ⚠
- p.Arg138Cys Single submitter ⚠
- p.Arg143Cys Single submitter ⚠
- p.Arg158His Single submitter ⚠
- p.Arg215His Single submitter
- p.Arg234Gln Single submitter ⚠
- p.Arg234Trp Single submitter ⚠
- p.Arg356Gln Single submitter ⚠
- p.Arg371Gln Single submitter ⚠
- p.Arg37Gln Single submitter ⚠
- p.Arg403Gly Single submitter ⚠
- p.Arg419His Single submitter ⚠
- p.Arg441Gln Single submitter ⚠
- p.Arg445His Single submitter ⚠
- p.Arg495Gln Single submitter ⚠
- p.Arg503Gln Single submitter
- p.Arg55His Single submitter ⚠
- p.Arg596Cys Single submitter ⚠
- p.Arg632His Single submitter
- p.Arg664Ser Single submitter ⚠
- p.Arg667Gln Single submitter ⚠
- p.Arg689Lys Single submitter ⚠
- p.Arg695Cys Single submitter ⚠
- p.Arg695His Single submitter ⚠
- p.Arg767Cys Single submitter ⚠
- p.Arg78Trp Single submitter ⚠
- p.Asn181Lys Single submitter ⚠
- p.Asn50Ser Single submitter ⚠
- p.Asn58Lys Single submitter ⚠
- p.Asn773Ser Single submitter ⚠
- p.Asn796Ser Single submitter
- p.Asp280Glu Single submitter ⚠
- p.Asp294Ala Single submitter ⚠
- p.Asp338Tyr Single submitter ⚠
- p.Asp42Gly Single submitter ⚠
- p.Asp541Asn Single submitter ⚠
- p.Asp601Gly Single submitter ⚠
- p.Asp676Gly Single submitter ⚠
- p.Asp684Glu Single submitter ⚠
- p.Asp753Gly Single submitter ⚠
- p.Asp795Glu Single submitter ⚠
- p.Asp82His Single submitter ⚠
- p.Cys119Arg Single submitter ⚠
- p.Cys126Phe Single submitter ⚠
- p.Gln761Leu Single submitter Meier-Gorlin syndrome ⚠
- p.Gln77Arg Single submitter
- p.Gln77Leu Single submitter ⚠
- p.Glu180Asp Single submitter ⚠
- p.Glu669Lys Single submitter ⚠
- p.Glu778Asp Single submitter ⚠
- p.Gly211Ser Single submitter ⚠
- p.Gly345Val Single submitter ⚠
- p.Gly437Ser Single submitter ⚠
- p.His196Arg Single submitter ⚠
- p.Ile317Val Single submitter ⚠
- p.Ile422Thr Single submitter ⚠
- p.Ile526Thr Single submitter ⚠
- p.Leu102Pro Single submitter ⚠
- p.Leu136Pro Single submitter
- p.Leu190Phe Single submitter ⚠
- p.Leu225Phe Single submitter ⚠
- p.Leu299Arg Single submitter ⚠
- p.Leu482Val Single submitter ⚠
- p.Leu73Gln Single submitter
- p.Leu73Val Single submitter ⚠
- p.Lys177Thr Single submitter ⚠
- p.Lys289Glu Single submitter ⚠
- p.Lys570Met Single submitter ⚠
- p.Lys660Thr Single submitter ⚠
- p.Lys791Gln Single submitter ⚠
- p.Lys81Arg Single submitter ⚠
- p.Lys93Arg Single submitter ⚠
- p.Met466Val Single submitter ⚠
- p.Met518Val Single submitter ⚠
- p.Met562Ile Single submitter ⚠
- p.Met717Val Single submitter ⚠
- p.Met765Leu Single submitter ⚠
- p.Met799Ile Single submitter ⚠
- p.Phe120Leu Single submitter ⚠
- p.Phe256Leu Single submitter ⚠
- p.Phe76Tyr Single submitter ⚠
- p.Phe806Leu Single submitter ⚠
- p.Pro169Thr Single submitter
- p.Pro183Ser Single submitter ⚠
- p.Pro183Thr Single submitter ⚠
- p.Pro205Leu Single submitter ⚠
- p.Pro274Leu Single submitter ⚠
- p.Pro454Ser Single submitter ⚠
- p.Pro707Leu Single submitter ⚠
- p.Pro718Ser Single submitter ⚠
- p.Ser191Phe Single submitter ⚠
- p.Ser586Leu Single submitter ⚠
- p.Ser595Ala Single submitter ⚠
- p.Ser634Asn Single submitter ⚠
- p.Ser681Thr Single submitter ⚠
- p.Ser86Phe Single submitter ⚠
- p.Thr151Asn Single submitter ⚠
- p.Thr186Ile Single submitter ⚠
- p.Thr200Ser Single submitter ⚠
- p.Thr252Ala Single submitter ⚠
- p.Thr383Ser Single submitter
- p.Thr420Ala Single submitter ⚠
- p.Thr607Ala Single submitter ⚠
- p.Thr610Ile Single submitter ⚠
- p.Tyr147Asp Single submitter ⚠
- p.Tyr188Cys Single submitter ⚠
- p.Tyr651Cys Single submitter ⚠
- p.Tyr99Cys Single submitter ⚠
- p.Val100Leu Single submitter ⚠
- p.Val111Leu Single submitter ⚠
- p.Val217Leu Single submitter ⚠
- p.Val219Ile Single submitter ⚠
- p.Val238Ala Single submitter ⚠
- p.Val448Leu Single submitter ⚠
- p.Val563Ala Single submitter ⚠
- p.Val574Leu Single submitter ⚠
- p.Val74Ile Single submitter ⚠