MCM7 — 162 ClinVar variants
All ClinVar germline MCM7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 135 flagged for review →
6 Pathogenic · 1 Conflicting · 5 Benign · 6 Likely benign · 144 Uncertain significance
Full MCM7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 135
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 91
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MCM7 p.Ala41Gly Uncertain significance Single submitter
- MCM7 p.Ala598Thr Uncertain significance Single submitter
- MCM7 p.Ala633Thr Uncertain significance Single submitter
- MCM7 p.Ala7Thr Uncertain significance Single submitter
- MCM7 p.Ala80Thr Uncertain significance Single submitter
- MCM7 p.Arg120Pro Uncertain significance Single submitter
- MCM7 p.Arg150Trp Uncertain significance Single submitter
- MCM7 p.Arg164His Uncertain significance Single submitter
- MCM7 p.Arg169Cys Uncertain significance Single submitter
- MCM7 p.Arg225Trp Uncertain significance Single submitter
- MCM7 p.Arg251His Uncertain significance Single submitter
- MCM7 p.Arg286Gln Uncertain significance Single submitter
- MCM7 p.Arg302Gln Uncertain significance Single submitter
- MCM7 p.Arg325Lys Uncertain significance Single submitter
- MCM7 p.Arg367Gln Uncertain significance Single submitter
- MCM7 p.Arg367Leu Uncertain significance Single submitter
- MCM7 p.Arg407Trp Uncertain significance Single submitter
- MCM7 p.Arg455Cys Uncertain significance Single submitter
- MCM7 p.Arg499His Uncertain significance Single submitter
- MCM7 p.Arg524Leu Uncertain significance Single submitter
- MCM7 p.Arg527Gln Uncertain significance Single submitter
- MCM7 p.Arg561His Uncertain significance Single submitter
- MCM7 p.Asn376Lys Uncertain significance Single submitter
- MCM7 p.Asn529Ser Uncertain significance Single submitter
- MCM7 p.Asn710Ser Uncertain significance Single submitter
- MCM7 p.Asp421Gly Uncertain significance Single submitter
- MCM7 p.Asp526Asn Uncertain significance Single submitter
- MCM7 p.Asp579Asn Uncertain significance Single submitter
- MCM7 p.Gln22His Uncertain significance Single submitter
- MCM7 p.Gln290Glu Uncertain significance Single submitter
- MCM7 p.Gln439His Uncertain significance Single submitter
- MCM7 p.Gln506Glu Uncertain significance Single submitter
- MCM7 p.Gln655Arg Uncertain significance Single submitter
- MCM7 p.Glu129Gln Uncertain significance Single submitter
- MCM7 p.Glu258Gly Uncertain significance Single submitter
- MCM7 p.Glu348Gln Uncertain significance Single submitter
- MCM7 p.Glu57Lys Uncertain significance Single submitter
- MCM7 p.Glu679Asp Uncertain significance Single submitter
- MCM7 p.Glu681Gln Uncertain significance Single submitter
- MCM7 p.Glu702Gln Uncertain significance Single submitter
- MCM7 p.Glu9Asp Uncertain significance Single submitter
- MCM7 p.Gly117Glu Uncertain significance Single submitter
- MCM7 p.Gly27Glu Uncertain significance Single submitter
- MCM7 p.Gly291Val Uncertain significance Single submitter
- MCM7 p.Ile103Met Uncertain significance Single submitter
- MCM7 p.Ile340Val Uncertain significance Single submitter
- MCM7 p.Ile537Val Uncertain significance Single submitter
- MCM7 p.Ile563Val Uncertain significance Single submitter
- MCM7 p.Ile609Val Uncertain significance Single submitter
- MCM7 p.Leu107Val Uncertain significance Single submitter
- MCM7 p.Leu293Arg Uncertain significance Single submitter
- MCM7 p.Leu414Phe Uncertain significance Single submitter
- MCM7 p.Leu520Pro Uncertain significance Single submitter
- MCM7 p.Leu645Pro Uncertain significance Single submitter
- MCM7 p.Leu698Val Uncertain significance Single submitter
- MCM7 p.Lys159Asn Uncertain significance Single submitter
- MCM7 p.Lys174Arg Uncertain significance Single submitter
- MCM7 p.Met108Val Uncertain significance Single submitter
- MCM7 p.Met109Val Uncertain significance Single submitter
- MCM7 p.Met205Val Uncertain significance Single submitter
- MCM7 p.Met559Arg Uncertain significance Single submitter
- MCM7 p.Met559Leu Uncertain significance Single submitter
- MCM7 p.Met639Val Uncertain significance Single submitter
- MCM7 p.Phe229Leu Uncertain significance Single submitter
- MCM7 p.Pro141Leu Uncertain significance Single submitter
- MCM7 p.Pro146Ser Uncertain significance Single submitter
- MCM7 p.Pro383Ala Uncertain significance Single submitter
- MCM7 p.Pro490Leu Uncertain significance Single submitter
- MCM7 p.Pro508Ser Uncertain significance Single submitter
- MCM7 p.Pro548Ala Uncertain significance Single submitter
- MCM7 p.Pro548Arg Uncertain significance Single submitter
- MCM7 p.Pro657Leu Uncertain significance Single submitter
- MCM7 p.Pro691Ser Uncertain significance Single submitter
- MCM7 p.Ser252Asn Uncertain significance Single submitter
- MCM7 p.Ser272Gly Uncertain significance Single submitter
- MCM7 p.Thr191Ile Uncertain significance Single submitter
- MCM7 p.Thr405Ala Uncertain significance Single submitter
- MCM7 p.Thr415Met Uncertain significance Single submitter
- MCM7 p.Thr428Ile Uncertain significance Single submitter
- MCM7 p.Thr599Ala Uncertain significance Single submitter
- MCM7 p.Thr651Ile Uncertain significance Single submitter
- MCM7 p.Tyr345His Uncertain significance Single submitter
- MCM7 p.Val101Ile Uncertain significance Single submitter
- MCM7 p.Val119Asp Uncertain significance Single submitter
- MCM7 p.Val423Leu Uncertain significance Single submitter
- MCM7 p.Val423Met Uncertain significance Single submitter
- MCM7 p.Val46Ala Uncertain significance Single submitter
- MCM7 p.Val586Met Uncertain significance Single submitter
- MCM7 p.Val624Ala Uncertain significance Single submitter
- MCM7 p.Val624Met Uncertain significance Single submitter
- MCM7 p.Val625Met Uncertain significance Single submitter
Predictors split 43
The independent predictors disagree with each other — read with care.
-
MCM7 p.Gly259Ala
Pathogenic
Multiple submitters
astigmatism
- MCM7 p.Ala300Val Uncertain significance Single submitter
- MCM7 p.Arg114Trp Uncertain significance Single submitter
- MCM7 p.Arg132Cys Uncertain significance Single submitter
- MCM7 p.Arg147Pro Uncertain significance Single submitter
- MCM7 p.Arg153Trp Uncertain significance Single submitter
- MCM7 p.Arg164Pro Uncertain significance Single submitter
- MCM7 p.Arg282Cys Uncertain significance Single submitter
- MCM7 p.Arg302Trp Uncertain significance Single submitter
- MCM7 p.Arg420Thr Uncertain significance Single submitter
- MCM7 p.Arg499Cys Uncertain significance Single submitter
- MCM7 p.Arg545Trp Uncertain significance Single submitter
- MCM7 p.Arg567Cys Uncertain significance Single submitter
- MCM7 p.Arg567Gly Uncertain significance Single submitter
- MCM7 p.Arg666Cys Uncertain significance Single submitter
- MCM7 p.Arg72Cys Uncertain significance Single submitter
- MCM7 p.Asn631Ile Uncertain significance Single submitter
- MCM7 p.Asp155Tyr Uncertain significance Single submitter
- MCM7 p.Asp269Asn Uncertain significance Single submitter
- MCM7 p.Asp349Asn Uncertain significance Single submitter
- MCM7 p.Asp51Gly Uncertain significance Single submitter
- MCM7 p.Gln36His Uncertain significance Single submitter
- MCM7 p.Gln522Glu Uncertain significance Single submitter
- MCM7 p.Glu19Lys Uncertain significance Single submitter
- MCM7 p.Gly117Trp Uncertain significance Single submitter
- MCM7 p.Gly27Arg Uncertain significance Single submitter
- MCM7 p.Gly346Glu Uncertain significance Single submitter
- MCM7 p.His347Gln Uncertain significance Single submitter
- MCM7 p.Ile634Thr Uncertain significance Single submitter
- MCM7 p.Leu390Phe Uncertain significance Single submitter
- MCM7 p.Lys370Asn Uncertain significance Single submitter
- MCM7 p.Met109Thr Uncertain significance Single submitter
- MCM7 p.Met131Ile Uncertain significance Single submitter
- MCM7 p.Met201Ile Uncertain significance Single submitter
- MCM7 p.Met369Ile Uncertain significance Single submitter
- MCM7 p.Met556Thr Uncertain significance Single submitter
- MCM7 p.Phe694Leu Uncertain significance Single submitter
- MCM7 p.Pro86Leu Uncertain significance Single submitter
- MCM7 p.Ser241Gly Uncertain significance Single submitter
- MCM7 p.Thr404Ala Uncertain significance Single submitter
- MCM7 p.Tyr333Phe Uncertain significance Single submitter
-
MCM7 p.Tyr539Cys
Pathogenic
Single submitter
Meier-Gorlin syndrome
- MCM7 p.Val63Gly Uncertain significance Single submitter
All MCM7 variants
Pathogenic 6
- p.Gly259Ala Multiple submitters astigmatism ⚠
- c.401+2dup Single submitter Multi-system disorder with neonatal progeroid appearance, lipodystrophy and adrenal insufficiency
- p.Arg527Ter Single submitter Meier-Gorlin syndrome
- p.Gln139Ter Single submitter Meier-Gorlin syndrome
- p.Gln45Ter Single submitter Trichiasis
- p.Tyr539Cys Single submitter Meier-Gorlin syndrome ⚠
Conflicting classifications of pathogenicity 1
- p.Gly473Ser Single submitter ⚠
Benign 5
- p.His459= Multiple submitters
- p.Thr415= Multiple submitters
- p.Val622= Multiple submitters
- p.Arg114Gln Single submitter
- p.Arg527= Single submitter
Likely benign 6
- p.Leu281= Multiple submitters
- p.Arg653= Single submitter
- p.Glu591Asp Single submitter
- p.Glu90Lys Single submitter
- p.Ile280Val Single submitter
- p.Val665Ile Single submitter
Uncertain significance 144
- p.Ala300Val Single submitter ⚠
- p.Ala398Val Single submitter
- p.Ala41Gly Single submitter ⚠
- p.Ala472Gly Single submitter
- p.Ala598Thr Single submitter ⚠
- p.Ala633Thr Single submitter ⚠
- p.Ala7Thr Single submitter ⚠
- p.Ala80Thr Single submitter ⚠
- p.Arg114Trp Single submitter ⚠
- p.Arg120Pro Single submitter ⚠
- p.Arg132Cys Single submitter ⚠
- p.Arg147Pro Single submitter ⚠
- p.Arg150Trp Single submitter ⚠
- p.Arg153Trp Single submitter ⚠
- p.Arg164Cys Single submitter
- p.Arg164His Single submitter ⚠
- p.Arg164Pro Single submitter ⚠
- p.Arg169Cys Single submitter ⚠
- p.Arg225Trp Single submitter ⚠
- p.Arg251His Single submitter ⚠
- p.Arg282Cys Single submitter ⚠
- p.Arg286Gln Single submitter ⚠
- p.Arg302Gln Single submitter ⚠
- p.Arg302Trp Single submitter ⚠
- p.Arg325Lys Single submitter ⚠
- p.Arg367Gln Single submitter ⚠
- p.Arg367Leu Single submitter ⚠
- p.Arg407Trp Single submitter ⚠
- p.Arg420Thr Single submitter ⚠
- p.Arg455Cys Single submitter ⚠
- p.Arg499Cys Single submitter ⚠
- p.Arg499His Single submitter ⚠
- p.Arg524Leu Single submitter ⚠
- p.Arg527Gln Single submitter ⚠
- p.Arg545Trp Single submitter ⚠
- p.Arg561Cys Single submitter
- p.Arg561His Single submitter ⚠
- p.Arg567Cys Single submitter ⚠
- p.Arg567Gly Single submitter ⚠
- p.Arg618Cys Single submitter
- p.Arg666Cys Single submitter ⚠
- p.Arg687Cys Single submitter
- p.Arg72Cys Single submitter ⚠
- p.Arg72His Single submitter
- p.Asn376Lys Single submitter ⚠
- p.Asn529Ser Single submitter ⚠
- p.Asn631Ile Single submitter ⚠
- p.Asn710Ser Single submitter ⚠
- p.Asp155Tyr Single submitter ⚠
- p.Asp269Asn Single submitter ⚠
- p.Asp349Asn Single submitter ⚠
- p.Asp421Gly Single submitter ⚠
- p.Asp51Gly Single submitter ⚠
- p.Asp526Asn Single submitter ⚠
- p.Asp579Asn Single submitter ⚠
- p.Gln22His Single submitter ⚠
- p.Gln290Glu Single submitter ⚠
- p.Gln36His Single submitter ⚠
- p.Gln439His Single submitter ⚠
- p.Gln506Glu Single submitter ⚠
- p.Gln522Glu Single submitter ⚠
- p.Gln655Arg Single submitter ⚠
- p.Glu129Gln Single submitter ⚠
- p.Glu19Lys Single submitter ⚠
- p.Glu258Gly Single submitter ⚠
- p.Glu348Gln Single submitter ⚠
- p.Glu44Lys Single submitter
- p.Glu57Lys Single submitter ⚠
- p.Glu679Asp Single submitter ⚠
- p.Glu681Gln Single submitter ⚠
- p.Glu702Gln Single submitter ⚠
- p.Glu9Asp Single submitter ⚠
- p.Gly117Glu Single submitter ⚠
- p.Gly117Trp Single submitter ⚠
- p.Gly27Arg Single submitter ⚠
- p.Gly27Glu Single submitter ⚠
- p.Gly291Val Single submitter ⚠
- p.Gly346Glu Single submitter ⚠
- p.His347Gln Single submitter ⚠
- p.Ile103Met Single submitter ⚠
- p.Ile340Val Single submitter ⚠
- p.Ile537Val Single submitter ⚠
- p.Ile563Val Single submitter ⚠
- p.Ile609Val Single submitter ⚠
- p.Ile634Thr Single submitter ⚠
- p.Leu107Val Single submitter ⚠
- p.Leu293Arg Single submitter ⚠
- p.Leu390Phe Single submitter ⚠
- p.Leu414Phe Single submitter ⚠
- p.Leu520Pro Single submitter ⚠
- p.Leu645Pro Single submitter ⚠
- p.Leu698Val Single submitter ⚠
- p.Lys159Asn Single submitter ⚠
- p.Lys159fs Single submitter MCM7-related disorder
- p.Lys174Arg Single submitter ⚠
- p.Lys370Asn Single submitter ⚠
- p.Met108Val Single submitter ⚠
- p.Met109Thr Single submitter ⚠
- p.Met109Val Single submitter ⚠
- p.Met131Ile Single submitter ⚠
- p.Met131Thr Single submitter
- p.Met201Ile Single submitter ⚠
- p.Met205Val Single submitter ⚠
- p.Met369Ile Single submitter ⚠
- p.Met556Thr Single submitter ⚠
- p.Met559Arg Single submitter ⚠
- p.Met559Leu Single submitter ⚠
- p.Met639Val Single submitter ⚠
- p.Phe229Leu Single submitter ⚠
- p.Phe694Leu Single submitter ⚠
- p.Pro141Leu Single submitter ⚠
- p.Pro146Ser Single submitter ⚠
- p.Pro383Ala Single submitter ⚠
- p.Pro490Leu Single submitter ⚠
- p.Pro508Ser Single submitter ⚠
- p.Pro548Ala Single submitter ⚠
- p.Pro548Arg Single submitter ⚠
- p.Pro657Leu Single submitter ⚠
- p.Pro691Ser Single submitter ⚠
- p.Pro86Leu Single submitter ⚠
- p.Pro86Ser Single submitter
- p.Ser241Gly Single submitter ⚠
- p.Ser252Asn Single submitter ⚠
- p.Ser272Gly Single submitter ⚠
- p.Thr191Ile Single submitter ⚠
- p.Thr224Pro Single submitter
- p.Thr404Ala Single submitter ⚠
- p.Thr405Ala Single submitter ⚠
- p.Thr415Met Single submitter ⚠
- p.Thr428Ile Single submitter ⚠
- p.Thr599Ala Single submitter ⚠
- p.Thr651Ile Single submitter ⚠
- p.Tyr333Phe Single submitter ⚠
- p.Tyr345His Single submitter ⚠
- p.Val101Ile Single submitter ⚠
- p.Val119Asp Single submitter ⚠
- p.Val423Leu Single submitter ⚠
- p.Val423Met Single submitter ⚠
- p.Val46Ala Single submitter ⚠
- p.Val586Met Single submitter ⚠
- p.Val624Ala Single submitter ⚠
- p.Val624Met Single submitter ⚠
- p.Val625Met Single submitter ⚠
- p.Val63Gly Single submitter ⚠