Sugi Variant

Sugi Variant/MDFIC

MDFIC — 61 ClinVar variants

All ClinVar germline MDFIC variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 38 flagged for review →

3 Pathogenic · 2 Likely pathogenic · 8 Likely benign · 48 Uncertain significance

Full MDFIC gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 38

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 38

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

All MDFIC variants

Pathogenic 3

Likely pathogenic 2

Likely benign 8

Uncertain significance 48