ME1 — 54 ClinVar variants
All ClinVar germline ME1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 49 flagged for review →
1 Benign · 1 Likely benign · 52 Uncertain significance
Full ME1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 49
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 37
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ME1 p.Ala302Thr Uncertain significance Single submitter
- ME1 p.Ala310Val Uncertain significance Single submitter
- ME1 p.Ala467Ser Uncertain significance Single submitter
- ME1 p.Arg118Gln Uncertain significance Single submitter
- ME1 p.Arg155Leu Uncertain significance Single submitter
- ME1 p.Arg212Gln Uncertain significance Single submitter
- ME1 p.Arg344Cys Uncertain significance Single submitter
- ME1 p.Asn398Ser Uncertain significance Single submitter
- ME1 p.Asn453Ser Uncertain significance Single submitter
- ME1 p.Asp550Val Uncertain significance Single submitter
- ME1 p.Asp571Glu Uncertain significance Single submitter
- ME1 p.Asp93Asn Uncertain significance Single submitter
- ME1 p.Gln295His Uncertain significance Single submitter
- ME1 p.Gln451Pro Uncertain significance Single submitter
- ME1 p.Glu4Gln Uncertain significance Single submitter
- ME1 p.Glu562Lys Uncertain significance Single submitter
- ME1 p.Glu95Asp Uncertain significance Single submitter
- ME1 p.His356Arg Uncertain significance Single submitter
- ME1 p.Ile242Asn Uncertain significance Single submitter
- ME1 p.Ile429Val Uncertain significance Single submitter
- ME1 p.Lys492Glu Uncertain significance Single submitter
- ME1 p.Met238Ile Uncertain significance Single submitter
- ME1 p.Met238Thr Uncertain significance Single submitter
- ME1 p.Phe539Ile Uncertain significance Single submitter
- ME1 p.Pro323Ser Uncertain significance Single submitter
- ME1 p.Pro459Arg Uncertain significance Single submitter
- ME1 p.Pro554Ser Uncertain significance Single submitter
- ME1 p.Ser114Arg Uncertain significance Single submitter
- ME1 p.Thr296Ile Uncertain significance Single submitter
- ME1 p.Thr424Ile Uncertain significance Single submitter
- ME1 p.Thr440Ile Uncertain significance Single submitter
- ME1 p.Thr568Asn Uncertain significance Single submitter
- ME1 p.Trp332Cys Uncertain significance Single submitter
- ME1 p.Trp559Arg Uncertain significance Single submitter
- ME1 p.Val171Met Uncertain significance Single submitter
- ME1 p.Val276Ile Uncertain significance Single submitter
- ME1 p.Val489Met Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- ME1 p.Arg254Cys Uncertain significance Single submitter
- ME1 p.Arg400Trp Uncertain significance Single submitter
- ME1 p.Asn443Lys Uncertain significance Single submitter
- ME1 p.Asp77Tyr Uncertain significance Single submitter
- ME1 p.Leu376Val Uncertain significance Single submitter
- ME1 p.Met98Ile Uncertain significance Single submitter
- ME1 p.Ser411Gly Uncertain significance Single submitter
- ME1 p.Ser542Pro Uncertain significance Single submitter
- ME1 p.Thr31Ala Uncertain significance Single submitter
- ME1 p.Thr348Ile Uncertain significance Single submitter
- ME1 p.Val489Leu Uncertain significance Single submitter
-
ME1 p.Asn249Ser
Likely benign
No assertion criteria
EBV-positive nodal T- and NK-cell lymphoma
All ME1 variants
Benign 1
- p.Leu479= Single submitter
Likely benign 1
- p.Asn249Ser No assertion criteria EBV-positive nodal T- and NK-cell lymphoma ⚠
Uncertain significance 52
- p.Ala302Thr Single submitter ⚠
- p.Ala310Val Single submitter ⚠
- p.Ala467Ser Single submitter ⚠
- p.Arg118Gln Single submitter ⚠
- p.Arg155Leu Single submitter ⚠
- p.Arg212Gln Single submitter ⚠
- p.Arg254Cys Single submitter ⚠
- p.Arg344Cys Single submitter ⚠
- p.Arg400Trp Single submitter ⚠
- p.Asn398Ser Single submitter ⚠
- p.Asn443Lys Single submitter ⚠
- p.Asn453Ser Single submitter ⚠
- p.Asp550Val Single submitter ⚠
- p.Asp571Glu Single submitter ⚠
- p.Asp77Tyr Single submitter ⚠
- p.Asp93Asn Single submitter ⚠
- p.Gln295His Single submitter ⚠
- p.Gln451Pro Single submitter ⚠
- p.Gln79Arg Single submitter
- p.Glu4Gln Single submitter ⚠
- p.Glu562Lys Single submitter ⚠
- p.Glu95Asp Single submitter ⚠
- p.Gly131Arg Single submitter
- p.His356Arg Single submitter ⚠
- p.Ile242Asn Single submitter ⚠
- p.Ile429Val Single submitter ⚠
- p.Leu376Val Single submitter ⚠
- p.Lys492Glu Single submitter ⚠
- p.Met238Ile Single submitter ⚠
- p.Met238Thr Single submitter ⚠
- p.Met98Ile Single submitter ⚠
- p.Phe539Ile Single submitter ⚠
- p.Pro323Ser Single submitter ⚠
- p.Pro459Arg Single submitter ⚠
- p.Pro502His Single submitter
- p.Pro554Ser Single submitter ⚠
- p.Ser114Arg Single submitter ⚠
- p.Ser411Gly Single submitter ⚠
- p.Ser542Pro Single submitter ⚠
- p.Thr296Ile Single submitter ⚠
- p.Thr31Ala Single submitter ⚠
- p.Thr348Ile Single submitter ⚠
- p.Thr424Ile Single submitter ⚠
- p.Thr440Ile Single submitter ⚠
- p.Thr481Ile Single submitter
- p.Thr568Asn Single submitter ⚠
- p.Trp332Cys Single submitter ⚠
- p.Trp559Arg Single submitter ⚠
- p.Val171Met Single submitter ⚠
- p.Val276Ile Single submitter ⚠
- p.Val489Leu Single submitter ⚠
- p.Val489Met Single submitter ⚠