ME3 — 71 ClinVar variants
All ClinVar germline ME3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 68 flagged for review →
1 Benign · 2 Likely benign · 68 Uncertain significance
Full ME3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 68
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ME3 p.Ala21Thr Uncertain significance Single submitter
- ME3 p.Arg190Cys Uncertain significance Single submitter
- ME3 p.Arg24Pro Uncertain significance Single submitter
- ME3 p.Arg42Ser Uncertain significance Single submitter
- ME3 p.Asn117Lys Uncertain significance Single submitter
- ME3 p.Asn173Ser Uncertain significance Single submitter
- ME3 p.Asn488Thr Uncertain significance Single submitter
- ME3 p.Asn60His Uncertain significance Single submitter
- ME3 p.Cys34Arg Uncertain significance Single submitter
- ME3 p.Cys450Arg Uncertain significance Single submitter
- ME3 p.Gln249Pro Uncertain significance Single submitter
- ME3 p.Glu339Lys Uncertain significance Single submitter
- ME3 p.Glu449Lys Uncertain significance Single submitter
- ME3 p.Glu460Lys Uncertain significance Single submitter
- ME3 p.His252Gln Uncertain significance Single submitter
- ME3 p.Ile108Val Uncertain significance Single submitter
- ME3 p.Ile412Thr Uncertain significance Single submitter
- ME3 p.Leu120Pro Uncertain significance Single submitter
- ME3 p.Leu172Arg Uncertain significance Single submitter
- ME3 p.Met171Ile Uncertain significance Single submitter
- ME3 p.Met94Ile Uncertain significance Single submitter
- ME3 p.Pro220Leu Uncertain significance Single submitter
- ME3 p.Pro38Ser Uncertain significance Single submitter
- ME3 p.Pro40Arg Uncertain significance Single submitter
- ME3 p.Thr213Met Uncertain significance Single submitter
- ME3 p.Thr581Ile Uncertain significance Single submitter
- ME3 p.Thr588Ile Uncertain significance Single submitter
- ME3 p.Trp25Arg Uncertain significance Single submitter
- ME3 p.Val124Leu Uncertain significance Single submitter
- ME3 p.Val218Met Uncertain significance Single submitter
Predictors split 38
The independent predictors disagree with each other — read with care.
- ME3 p.Ala29Glu Uncertain significance Single submitter
- ME3 p.Arg10Trp Uncertain significance Single submitter
- ME3 p.Arg289His Uncertain significance Single submitter
- ME3 p.Arg321Gln Uncertain significance Single submitter
- ME3 p.Arg404Met Uncertain significance Single submitter
- ME3 p.Arg462Gln Uncertain significance Single submitter
- ME3 p.Asn284Lys Uncertain significance Single submitter
- ME3 p.Asn284Ser Uncertain significance Single submitter
- ME3 p.Asn56Ile Uncertain significance Single submitter
- ME3 p.Asn600Tyr Uncertain significance Single submitter
- ME3 p.Asp178Gly Uncertain significance Single submitter
- ME3 p.Asp428Asn Uncertain significance Single submitter
- ME3 p.Asp554Asn Uncertain significance Single submitter
- ME3 p.Glu353Gln Uncertain significance Single submitter
- ME3 p.Glu353Lys Uncertain significance Single submitter
- ME3 p.Glu387Lys Uncertain significance Single submitter
- ME3 p.Glu434Lys Uncertain significance Single submitter
- ME3 p.Glu98Lys Uncertain significance Single submitter
- ME3 p.Gly166Asp Uncertain significance Single submitter
- ME3 p.Gly356Ser Uncertain significance Single submitter
- ME3 p.His346Tyr Uncertain significance Single submitter
- ME3 p.Leu125Val Uncertain significance Single submitter
- ME3 p.Leu242Val Uncertain significance Single submitter
- ME3 p.Leu348Phe Uncertain significance Single submitter
- ME3 p.Pro358Leu Uncertain significance Single submitter
- ME3 p.Pro38Leu Uncertain significance Single submitter
- ME3 p.Ser473Arg Uncertain significance Single submitter
- ME3 p.Ser85Asn Uncertain significance Single submitter
- ME3 p.Thr151Ser Uncertain significance Single submitter
- ME3 p.Thr170Arg Uncertain significance Single submitter
- ME3 p.Thr422Met Uncertain significance Single submitter
- ME3 p.Thr451Met Uncertain significance Single submitter
- ME3 p.Tyr565His Uncertain significance Single submitter
- ME3 p.Val183Met Uncertain significance Single submitter
- ME3 p.Val251Met Uncertain significance Single submitter
- ME3 p.Val331Ala Uncertain significance Single submitter
- ME3 p.Val331Gly Uncertain significance Single submitter
- ME3 p.Val406Leu Uncertain significance Single submitter
All ME3 variants
Benign 1
- p.Leu228= Single submitter
Uncertain significance 68
- p.Ala21Thr Single submitter ⚠
- p.Ala29Glu Single submitter ⚠
- p.Arg10Trp Single submitter ⚠
- p.Arg190Cys Single submitter ⚠
- p.Arg24Pro Single submitter ⚠
- p.Arg289His Single submitter ⚠
- p.Arg321Gln Single submitter ⚠
- p.Arg404Met Single submitter ⚠
- p.Arg42Ser Single submitter ⚠
- p.Arg462Gln Single submitter ⚠
- p.Asn117Lys Single submitter ⚠
- p.Asn173Ser Single submitter ⚠
- p.Asn284Lys Single submitter ⚠
- p.Asn284Ser Single submitter ⚠
- p.Asn488Thr Single submitter ⚠
- p.Asn56Ile Single submitter ⚠
- p.Asn600Tyr Single submitter ⚠
- p.Asn60His Single submitter ⚠
- p.Asp178Gly Single submitter ⚠
- p.Asp428Asn Single submitter ⚠
- p.Asp554Asn Single submitter ⚠
- p.Cys34Arg Single submitter ⚠
- p.Cys450Arg Single submitter ⚠
- p.Gln249Pro Single submitter ⚠
- p.Glu339Lys Single submitter ⚠
- p.Glu353Gln Single submitter ⚠
- p.Glu353Lys Single submitter ⚠
- p.Glu387Lys Single submitter ⚠
- p.Glu434Lys Single submitter ⚠
- p.Glu449Lys Single submitter ⚠
- p.Glu460Lys Single submitter ⚠
- p.Glu98Lys Single submitter ⚠
- p.Gly166Asp Single submitter ⚠
- p.Gly356Ser Single submitter ⚠
- p.His252Gln Single submitter ⚠
- p.His346Tyr Single submitter ⚠
- p.Ile108Val Single submitter ⚠
- p.Ile412Thr Single submitter ⚠
- p.Leu120Pro Single submitter ⚠
- p.Leu125Val Single submitter ⚠
- p.Leu172Arg Single submitter ⚠
- p.Leu242Val Single submitter ⚠
- p.Leu348Phe Single submitter ⚠
- p.Met171Ile Single submitter ⚠
- p.Met94Ile Single submitter ⚠
- p.Pro220Leu Single submitter ⚠
- p.Pro358Leu Single submitter ⚠
- p.Pro38Leu Single submitter ⚠
- p.Pro38Ser Single submitter ⚠
- p.Pro40Arg Single submitter ⚠
- p.Ser473Arg Single submitter ⚠
- p.Ser85Asn Single submitter ⚠
- p.Thr151Ser Single submitter ⚠
- p.Thr170Arg Single submitter ⚠
- p.Thr213Met Single submitter ⚠
- p.Thr422Met Single submitter ⚠
- p.Thr451Met Single submitter ⚠
- p.Thr581Ile Single submitter ⚠
- p.Thr588Ile Single submitter ⚠
- p.Trp25Arg Single submitter ⚠
- p.Tyr565His Single submitter ⚠
- p.Val124Leu Single submitter ⚠
- p.Val183Met Single submitter ⚠
- p.Val218Met Single submitter ⚠
- p.Val251Met Single submitter ⚠
- p.Val331Ala Single submitter ⚠
- p.Val331Gly Single submitter ⚠
- p.Val406Leu Single submitter ⚠