MEP1B — 87 ClinVar variants
All ClinVar germline MEP1B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 81 flagged for review →
1 Likely benign · 86 Uncertain significance
Full MEP1B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 81
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 66
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MEP1B p.Ala142Val Uncertain significance Single submitter
- MEP1B p.Ala323Asp Uncertain significance Single submitter
- MEP1B p.Ala497Thr Uncertain significance Single submitter
- MEP1B p.Ala700Val Uncertain significance Single submitter
- MEP1B p.Arg131Lys Uncertain significance Single submitter
- MEP1B p.Arg169Gly Uncertain significance Single submitter
- MEP1B p.Arg516Trp Uncertain significance Single submitter
- MEP1B p.Arg650Gln Uncertain significance Single submitter
- MEP1B p.Asn301Ser Uncertain significance Single submitter
- MEP1B p.Asn366Ser Uncertain significance Single submitter
- MEP1B p.Asn697Ser Uncertain significance Single submitter
- MEP1B p.Asn93Ser Uncertain significance Single submitter
- MEP1B p.Asp170Tyr Uncertain significance Single submitter
- MEP1B p.Asp245His Uncertain significance Single submitter
- MEP1B p.Asp36Tyr Uncertain significance Single submitter
- MEP1B p.Asp418Gly Uncertain significance Single submitter
- MEP1B p.Asp527Gly Uncertain significance Single submitter
- MEP1B p.Asp651Glu Uncertain significance Single submitter
- MEP1B p.Cys427Phe Uncertain significance Single submitter
- MEP1B p.Cys677Ser Uncertain significance Single submitter
- MEP1B p.Gln439Glu Uncertain significance Single submitter
- MEP1B p.Gln631His Uncertain significance Single submitter
- MEP1B p.Glu296Gly Uncertain significance Single submitter
- MEP1B p.Glu634Lys Uncertain significance Single submitter
- MEP1B p.Gly141Arg Uncertain significance Single submitter
- MEP1B p.Gly141Trp Uncertain significance Single submitter
- MEP1B p.Gly307Val Uncertain significance Single submitter
- MEP1B p.Gly32Arg Uncertain significance Single submitter
- MEP1B p.Gly458Ser Uncertain significance Single submitter
- MEP1B p.His313Pro Uncertain significance Single submitter
- MEP1B p.His430Leu Uncertain significance Single submitter
- MEP1B p.Ile104Thr Uncertain significance Single submitter
- MEP1B p.Ile140Phe Uncertain significance Single submitter
- MEP1B p.Ile147Thr Uncertain significance Single submitter
- MEP1B p.Ile18Thr Uncertain significance Single submitter
- MEP1B p.Ile417Val Uncertain significance Single submitter
- MEP1B p.Ile508Val Uncertain significance Single submitter
- MEP1B p.Ile588Val Uncertain significance Single submitter
- MEP1B p.Leu158Pro Uncertain significance Single submitter
- MEP1B p.Leu345Phe Uncertain significance Single submitter
- MEP1B p.Leu79Arg Uncertain significance Single submitter
- MEP1B p.Leu79Pro Uncertain significance Single submitter
- MEP1B p.Lys107Asn Uncertain significance Single submitter
- MEP1B p.Lys120Met Uncertain significance Single submitter
- MEP1B p.Lys645Arg Uncertain significance Single submitter
- MEP1B p.Phe343Ser Uncertain significance Single submitter
- MEP1B p.Phe523Leu Uncertain significance Single submitter
- MEP1B p.Phe95Leu Uncertain significance Single submitter
- MEP1B p.Pro202Ala Uncertain significance Single submitter
- MEP1B p.Pro381Ser Uncertain significance Single submitter
- MEP1B p.Pro691Ser Uncertain significance Single submitter
- MEP1B p.Ser165Leu Uncertain significance Single submitter
- MEP1B p.Ser308Phe Uncertain significance Single submitter
- MEP1B p.Ser560Thr Uncertain significance Single submitter
- MEP1B p.Ser82Thr Uncertain significance Single submitter
- MEP1B p.Thr372Asn Uncertain significance Single submitter
- MEP1B p.Thr594Ala Uncertain significance Single submitter
- MEP1B p.Thr660Ala Uncertain significance Single submitter
- MEP1B p.Trp637Arg Uncertain significance Single submitter
- MEP1B p.Trp8Leu Uncertain significance Single submitter
- MEP1B p.Tyr346His Uncertain significance Single submitter
- MEP1B p.Tyr358Ser Uncertain significance Single submitter
- MEP1B p.Val173Ile Uncertain significance Single submitter
- MEP1B p.Val367Ala Uncertain significance Single submitter
- MEP1B p.Val539Met Uncertain significance Single submitter
- MEP1B p.Val673Ile Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- MEP1B p.Arg287Trp Uncertain significance Single submitter
- MEP1B p.Arg405Cys Uncertain significance Single submitter
- MEP1B p.Arg511Cys Uncertain significance Single submitter
- MEP1B p.Arg629Ser Uncertain significance Single submitter
- MEP1B p.Asp284Tyr Uncertain significance Single submitter
- MEP1B p.Asp284Val Uncertain significance Single submitter
- MEP1B p.Gly322Arg Uncertain significance Single submitter
- MEP1B p.Leu92Phe Uncertain significance Single submitter
- MEP1B p.Met667Ile Uncertain significance Single submitter
- MEP1B p.Phe154Leu Uncertain significance Single submitter
- MEP1B p.Ser264Leu Uncertain significance Single submitter
- MEP1B p.Ser329Ile Uncertain significance Single submitter
- MEP1B p.Ser609Pro Uncertain significance Single submitter
- MEP1B p.Thr149Ala Uncertain significance Single submitter
- MEP1B p.Thr564Ile Uncertain significance Single submitter
All MEP1B variants
Likely benign 1
- p.Arg622Gln Single submitter
Uncertain significance 86
- p.Ala142Val Single submitter ⚠
- p.Ala323Asp Single submitter ⚠
- p.Ala497Thr Single submitter ⚠
- p.Ala700Val Single submitter ⚠
- p.Arg131Lys Single submitter ⚠
- p.Arg169Gly Single submitter ⚠
- p.Arg287Trp Single submitter ⚠
- p.Arg405Cys Single submitter ⚠
- p.Arg511Cys Single submitter ⚠
- p.Arg516Trp Single submitter ⚠
- p.Arg629Ser Single submitter ⚠
- p.Arg650Gln Single submitter ⚠
- p.Asn301Ser Single submitter ⚠
- p.Asn366Ser Single submitter ⚠
- p.Asn41Ser Single submitter
- p.Asn697Ser Single submitter ⚠
- p.Asn93Ser Single submitter ⚠
- p.Asp170Tyr Single submitter ⚠
- p.Asp245His Single submitter ⚠
- p.Asp284Tyr Single submitter ⚠
- p.Asp284Val Single submitter ⚠
- p.Asp36Tyr Single submitter ⚠
- p.Asp418Gly Single submitter ⚠
- p.Asp527Gly Single submitter ⚠
- p.Asp651Glu Single submitter ⚠
- p.Cys427Phe Single submitter ⚠
- p.Cys677Ser Single submitter ⚠
- p.Gln439Glu Single submitter ⚠
- p.Gln631His Single submitter ⚠
- p.Glu296Gly Single submitter ⚠
- p.Glu634Lys Single submitter ⚠
- p.Gly141Arg Single submitter ⚠
- p.Gly141Trp Single submitter ⚠
- p.Gly307Val Single submitter ⚠
- p.Gly322Arg Single submitter ⚠
- p.Gly32Arg Single submitter ⚠
- p.Gly458Ser Single submitter ⚠
- p.His313Pro Single submitter ⚠
- p.His430Leu Single submitter ⚠
- p.Ile104Thr Single submitter ⚠
- p.Ile140Phe Single submitter ⚠
- p.Ile147Thr Single submitter ⚠
- p.Ile18Thr Single submitter ⚠
- p.Ile417Val Single submitter ⚠
- p.Ile508Val Single submitter ⚠
- p.Ile588Val Single submitter ⚠
- p.Leu158Pro Single submitter ⚠
- p.Leu345Phe Single submitter ⚠
- p.Leu79Arg Single submitter ⚠
- p.Leu79Pro Single submitter ⚠
- p.Leu92Phe Single submitter ⚠
- p.Lys107Asn Single submitter ⚠
- p.Lys120Met Single submitter ⚠
- p.Lys645Arg Single submitter ⚠
- p.Met667Ile Single submitter ⚠
- p.Phe154Leu Single submitter ⚠
- p.Phe343Ser Single submitter ⚠
- p.Phe523Leu Single submitter ⚠
- p.Phe95Leu Single submitter ⚠
- p.Pro202Ala Single submitter ⚠
- p.Pro381Ser Single submitter ⚠
- p.Pro691Ser Single submitter ⚠
- p.Ser165Leu Single submitter ⚠
- p.Ser165Thr Single submitter
- p.Ser264Leu Single submitter ⚠
- p.Ser308Phe Single submitter ⚠
- p.Ser329Ile Single submitter ⚠
- p.Ser560Thr Single submitter ⚠
- p.Ser609Pro Single submitter ⚠
- p.Ser82Thr Single submitter ⚠
- p.Thr149Ala Single submitter ⚠
- p.Thr149Ser Single submitter
- p.Thr372Asn Single submitter ⚠
- p.Thr564Ile Single submitter ⚠
- p.Thr594Ala Single submitter ⚠
- p.Thr660Ala Single submitter ⚠
- p.Trp432Ter Single submitter
- p.Trp637Arg Single submitter ⚠
- p.Trp637Leu Single submitter
- p.Trp8Leu Single submitter ⚠
- p.Tyr346His Single submitter ⚠
- p.Tyr358Ser Single submitter ⚠
- p.Val173Ile Single submitter ⚠
- p.Val367Ala Single submitter ⚠
- p.Val539Met Single submitter ⚠
- p.Val673Ile Single submitter ⚠