METTL14 — 28 ClinVar variants
All ClinVar germline METTL14 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 27 flagged for review →
1 Likely benign · 27 Uncertain significance
Full METTL14 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 27
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- METTL14 p.Ala25Val Uncertain significance Single submitter
- METTL14 p.Arg343Cys Uncertain significance Single submitter
- METTL14 p.Arg435Gln Uncertain significance Single submitter
- METTL14 p.Asp56Asn Uncertain significance Single submitter
- METTL14 p.Asp89Gly Uncertain significance Single submitter
- METTL14 p.Cys288Arg Uncertain significance Single submitter
- METTL14 p.Glu181Lys Uncertain significance Single submitter
- METTL14 p.Glu90Gln Uncertain significance Single submitter
- METTL14 p.Gly302Arg Uncertain significance Single submitter
- METTL14 p.Gly356Val Uncertain significance Single submitter
- METTL14 p.His449Arg Uncertain significance Single submitter
- METTL14 p.Ile231Val Uncertain significance Single submitter
- METTL14 p.Lys76Arg Uncertain significance Single submitter
- METTL14 p.Met168Leu Uncertain significance Single submitter
- METTL14 p.Pro194Leu Uncertain significance Single submitter
- METTL14 p.Ser27Asn Uncertain significance Single submitter
- METTL14 p.Ser379Asn Uncertain significance Single submitter
- METTL14 p.Ser432Thr Uncertain significance Single submitter
- METTL14 p.Thr57Asn Uncertain significance Single submitter
- METTL14 p.Tyr95Cys Uncertain significance Single submitter
- METTL14 p.Val188Met Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- METTL14 p.Arg349Gly Uncertain significance Single submitter
- METTL14 p.Gly238Glu Uncertain significance Single submitter
- METTL14 p.Gly417Glu Uncertain significance Single submitter
- METTL14 p.Gly444Val Uncertain significance Single submitter
- METTL14 p.Lys185Glu Uncertain significance Single submitter
- METTL14 p.Pro319Thr Uncertain significance Single submitter
All METTL14 variants
Likely benign 1
- p.Asp301= Single submitter
Uncertain significance 27
- p.Ala25Val Single submitter ⚠
- p.Arg343Cys Single submitter ⚠
- p.Arg349Gly Single submitter ⚠
- p.Arg435Gln Single submitter ⚠
- p.Asp56Asn Single submitter ⚠
- p.Asp89Gly Single submitter ⚠
- p.Cys288Arg Single submitter ⚠
- p.Glu181Lys Single submitter ⚠
- p.Glu90Gln Single submitter ⚠
- p.Gly238Glu Single submitter ⚠
- p.Gly302Arg Single submitter ⚠
- p.Gly356Val Single submitter ⚠
- p.Gly417Glu Single submitter ⚠
- p.Gly444Val Single submitter ⚠
- p.His449Arg Single submitter ⚠
- p.Ile231Val Single submitter ⚠
- p.Lys185Glu Single submitter ⚠
- p.Lys76Arg Single submitter ⚠
- p.Met168Leu Single submitter ⚠
- p.Pro194Leu Single submitter ⚠
- p.Pro319Thr Single submitter ⚠
- p.Ser27Asn Single submitter ⚠
- p.Ser379Asn Single submitter ⚠
- p.Ser432Thr Single submitter ⚠
- p.Thr57Asn Single submitter ⚠
- p.Tyr95Cys Single submitter ⚠
- p.Val188Met Single submitter ⚠