METTL16 — 51 ClinVar variants
All ClinVar germline METTL16 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 47 flagged for review →
4 Likely benign · 47 Uncertain significance
Full METTL16 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 47
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 45
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- METTL16 p.Ala405Ser Uncertain significance Single submitter
- METTL16 p.Ala492Asp Uncertain significance Single submitter
- METTL16 p.Arg104Gln Uncertain significance Single submitter
- METTL16 p.Arg263His Uncertain significance Single submitter
- METTL16 p.Arg302Gln Uncertain significance Single submitter
- METTL16 p.Arg332Cys Uncertain significance Single submitter
- METTL16 p.Arg437Gly Uncertain significance Single submitter
- METTL16 p.Arg437Trp Uncertain significance Single submitter
- METTL16 p.Arg503Ser Uncertain significance Single submitter
- METTL16 p.Asn376Tyr Uncertain significance Single submitter
- METTL16 p.Asn485His Uncertain significance Single submitter
- METTL16 p.Cys362Arg Uncertain significance Single submitter
- METTL16 p.Gln451Arg Uncertain significance Single submitter
- METTL16 p.Glu438Gln Uncertain significance Single submitter
- METTL16 p.Glu464Val Uncertain significance Single submitter
- METTL16 p.Glu50Lys Uncertain significance Single submitter
- METTL16 p.Gly223Ser Uncertain significance Single submitter
- METTL16 p.Gly425Asp Uncertain significance Single submitter
- METTL16 p.Gly482Ser Uncertain significance Single submitter
- METTL16 p.Gly512Ala Uncertain significance Single submitter
- METTL16 p.Gly512Arg Uncertain significance Single submitter
- METTL16 p.Gly94Arg Uncertain significance Single submitter
- METTL16 p.Gly94Ser Uncertain significance Single submitter
- METTL16 p.Leu165His Uncertain significance Single submitter
- METTL16 p.Leu305Ser Uncertain significance Single submitter
- METTL16 p.Leu436Pro Uncertain significance Single submitter
- METTL16 p.Lys159Glu Uncertain significance Single submitter
- METTL16 p.Lys240Arg Uncertain significance Single submitter
- METTL16 p.Lys269Arg Uncertain significance Single submitter
- METTL16 p.Lys364Arg Uncertain significance Single submitter
- METTL16 p.Lys505Arg Uncertain significance Single submitter
- METTL16 p.Met137Ile Uncertain significance Single submitter
- METTL16 p.Pro431Ala Uncertain significance Single submitter
- METTL16 p.Pro447Leu Uncertain significance Single submitter
- METTL16 p.Pro499Leu Uncertain significance Single submitter
- METTL16 p.Ser450Arg Uncertain significance Single submitter
- METTL16 p.Ser468Arg Uncertain significance Single submitter
- METTL16 p.Thr335Met Uncertain significance Single submitter
- METTL16 p.Thr463Ala Uncertain significance Single submitter
- METTL16 p.Thr463Lys Uncertain significance Single submitter
- METTL16 p.Val320Met Uncertain significance Single submitter
- METTL16 p.Val510Leu Uncertain significance Single submitter
- METTL16 p.Val522Ile Uncertain significance Single submitter
- METTL16 p.Val559Phe Uncertain significance Single submitter
- METTL16 p.Val561Ile Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All METTL16 variants
Likely benign 4
- p.Ala442= Single submitter
- p.Arg437Gln Single submitter
- p.Arg506His Single submitter
- p.Gly497Ser Single submitter
Uncertain significance 47
- p.Ala405Ser Single submitter ⚠
- p.Ala492Asp Single submitter ⚠
- p.Arg104Gln Single submitter ⚠
- p.Arg263His Single submitter ⚠
- p.Arg302Gln Single submitter ⚠
- p.Arg332Cys Single submitter ⚠
- p.Arg437Gly Single submitter ⚠
- p.Arg437Trp Single submitter ⚠
- p.Arg503Ser Single submitter ⚠
- p.Asn376Tyr Single submitter ⚠
- p.Asn485His Single submitter ⚠
- p.Cys362Arg Single submitter ⚠
- p.Gln451Arg Single submitter ⚠
- p.Glu261Lys Single submitter ⚠
- p.Glu438Gln Single submitter ⚠
- p.Glu464Val Single submitter ⚠
- p.Glu50Lys Single submitter ⚠
- p.Gly223Ser Single submitter ⚠
- p.Gly425Asp Single submitter ⚠
- p.Gly482Ser Single submitter ⚠
- p.Gly512Ala Single submitter ⚠
- p.Gly512Arg Single submitter ⚠
- p.Gly94Arg Single submitter ⚠
- p.Gly94Ser Single submitter ⚠
- p.Leu165His Single submitter ⚠
- p.Leu305Ser Single submitter ⚠
- p.Leu436Pro Single submitter ⚠
- p.Lys159Glu Single submitter ⚠
- p.Lys240Arg Single submitter ⚠
- p.Lys269Arg Single submitter ⚠
- p.Lys364Arg Single submitter ⚠
- p.Lys505Arg Single submitter ⚠
- p.Met137Ile Single submitter ⚠
- p.Pro431Ala Single submitter ⚠
- p.Pro447Leu Single submitter ⚠
- p.Pro499Leu Single submitter ⚠
- p.Ser450Arg Single submitter ⚠
- p.Ser468Arg Single submitter ⚠
- p.Thr164Ile Single submitter ⚠
- p.Thr335Met Single submitter ⚠
- p.Thr463Ala Single submitter ⚠
- p.Thr463Lys Single submitter ⚠
- p.Val320Met Single submitter ⚠
- p.Val510Leu Single submitter ⚠
- p.Val522Ile Single submitter ⚠
- p.Val559Phe Single submitter ⚠
- p.Val561Ile Single submitter ⚠