MGAT3 — 64 ClinVar variants
All ClinVar germline MGAT3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 55 flagged for review →
2 Benign · 5 Likely benign · 57 Uncertain significance
Full MGAT3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 55
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MGAT3 p.Ala164Ser Uncertain significance Single submitter
- MGAT3 p.Ala89Ser Uncertain significance Single submitter
- MGAT3 p.Arg147Trp Uncertain significance Single submitter
- MGAT3 p.Arg150Gly Uncertain significance Single submitter
- MGAT3 p.Arg514Cys Uncertain significance Single submitter
- MGAT3 p.Arg516Met Uncertain significance Single submitter
- MGAT3 p.Arg525Trp Uncertain significance Single submitter
- MGAT3 p.Arg5Gly Uncertain significance Single submitter
- MGAT3 p.Arg71Cys Uncertain significance Single submitter
- MGAT3 p.Arg71His Uncertain significance Single submitter
- MGAT3 p.Asn192Thr Uncertain significance Single submitter
- MGAT3 p.Asn44His Uncertain significance Single submitter
- MGAT3 p.Asp222Asn Uncertain significance Single submitter
- MGAT3 p.Asp492His Uncertain significance Single submitter
- MGAT3 p.Asp97His Uncertain significance Single submitter
- MGAT3 p.Gln385Arg Uncertain significance Single submitter
- MGAT3 p.Gln503Glu Uncertain significance Single submitter
- MGAT3 p.Glu157Asp Uncertain significance Single submitter
- MGAT3 p.Glu255Asp Uncertain significance Single submitter
- MGAT3 p.Glu471Asp Uncertain significance Single submitter
- MGAT3 p.Glu471Gln Uncertain significance Single submitter
- MGAT3 p.Glu530Asp Uncertain significance Single submitter
- MGAT3 p.Glu530Lys Uncertain significance Single submitter
- MGAT3 p.Gly517Cys Uncertain significance Single submitter
- MGAT3 p.Gly526Asp Uncertain significance Single submitter
- MGAT3 p.Gly66Val Uncertain significance Single submitter
- MGAT3 p.Met11Val Uncertain significance Single submitter
- MGAT3 p.Phe351Leu Uncertain significance Single submitter
- MGAT3 p.Pro130Arg Uncertain significance Single submitter
- MGAT3 p.Pro130Thr Uncertain significance Single submitter
- MGAT3 p.Pro137His Uncertain significance Single submitter
- MGAT3 p.Pro137Leu Uncertain significance Single submitter
- MGAT3 p.Pro149Thr Uncertain significance Single submitter
- MGAT3 p.Pro523Ser Uncertain significance Single submitter
- MGAT3 p.Pro73Ala Uncertain significance Single submitter
- MGAT3 p.Ser78Leu Uncertain significance Single submitter
- MGAT3 p.Ser87Thr Uncertain significance Single submitter
- MGAT3 p.Thr159Arg Uncertain significance Single submitter
- MGAT3 p.Tyr75Cys Uncertain significance Single submitter
- MGAT3 p.Val109Leu Uncertain significance Single submitter
- MGAT3 p.Val208Ile Uncertain significance Single submitter
- MGAT3 p.Val362Met Uncertain significance Single submitter
- MGAT3 p.Val96Leu Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- MGAT3 p.Arg324Ser Uncertain significance Single submitter
- MGAT3 p.Arg384Cys Uncertain significance Single submitter
- MGAT3 p.Arg393Ser Uncertain significance Single submitter
- MGAT3 p.Arg460Cys Uncertain significance Single submitter
- MGAT3 p.Asn192Lys Uncertain significance Single submitter
- MGAT3 p.Asp290Glu Uncertain significance Single submitter
- MGAT3 p.Gly285Ser Uncertain significance Single submitter
- MGAT3 p.Leu193Met Uncertain significance Single submitter
- MGAT3 p.Phe262Leu Uncertain significance Single submitter
- MGAT3 p.Ser347Leu Uncertain significance Single submitter
- MGAT3 p.Val187Glu Uncertain significance Single submitter
-
MGAT3 p.Asp439Asn
Likely benign
No assertion criteria
EBV-positive nodal T- and NK-cell lymphoma
All MGAT3 variants
Likely benign 5
- p.Ala155Thr Single submitter
- p.Ala372Thr Single submitter
- p.Leu98Phe Single submitter
- p.Pro522Leu Single submitter
- p.Asp439Asn No assertion criteria EBV-positive nodal T- and NK-cell lymphoma ⚠
Uncertain significance 57
- p.Ala164Ser Single submitter ⚠
- p.Ala89Ser Single submitter ⚠
- p.Arg147Trp Single submitter ⚠
- p.Arg150Gly Single submitter ⚠
- p.Arg308Gly Single submitter
- p.Arg324Ser Single submitter ⚠
- p.Arg384Cys Single submitter ⚠
- p.Arg393Ser Single submitter ⚠
- p.Arg460Cys Single submitter ⚠
- p.Arg514Cys Single submitter ⚠
- p.Arg516Met Single submitter ⚠
- p.Arg525Trp Single submitter ⚠
- p.Arg5Gly Single submitter ⚠
- p.Arg71Cys Single submitter ⚠
- p.Arg71His Single submitter ⚠
- p.Asn192Lys Single submitter ⚠
- p.Asn192Thr Single submitter ⚠
- p.Asn44His Single submitter ⚠
- p.Asp222Asn Single submitter ⚠
- p.Asp290Glu Single submitter ⚠
- p.Asp492His Single submitter ⚠
- p.Asp97His Single submitter ⚠
- p.Gln385Arg Single submitter ⚠
- p.Gln503Glu Single submitter ⚠
- p.Glu157Asp Single submitter ⚠
- p.Glu255Asp Single submitter ⚠
- p.Glu471Asp Single submitter ⚠
- p.Glu471Gln Single submitter ⚠
- p.Glu530Asp Single submitter ⚠
- p.Glu530Lys Single submitter ⚠
- p.Gly176Ser Single submitter
- p.Gly280Ser Single submitter
- p.Gly285Ser Single submitter ⚠
- p.Gly517Cys Single submitter ⚠
- p.Gly526Asp Single submitter ⚠
- p.Gly66Val Single submitter ⚠
- p.Leu193Met Single submitter ⚠
- p.Met11Val Single submitter ⚠
- p.Phe262Leu Single submitter ⚠
- p.Phe351Leu Single submitter ⚠
- p.Pro130Arg Single submitter ⚠
- p.Pro130Thr Single submitter ⚠
- p.Pro137His Single submitter ⚠
- p.Pro137Leu Single submitter ⚠
- p.Pro149Thr Single submitter ⚠
- p.Pro523Ser Single submitter ⚠
- p.Pro73Ala Single submitter ⚠
- p.Ser347Leu Single submitter ⚠
- p.Ser78Leu Single submitter ⚠
- p.Ser87Thr Single submitter ⚠
- p.Thr159Arg Single submitter ⚠
- p.Tyr75Cys Single submitter ⚠
- p.Val109Leu Single submitter ⚠
- p.Val187Glu Single submitter ⚠
- p.Val208Ile Single submitter ⚠
- p.Val362Met Single submitter ⚠
- p.Val96Leu Single submitter ⚠