MGMT — 43 ClinVar variants
All ClinVar germline MGMT variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
1 Benign · 6 Likely benign · 36 Uncertain significance
Full MGMT gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MGMT p.Ala126Gly Uncertain significance Single submitter
- MGMT p.Ala197Thr Uncertain significance Single submitter
- MGMT p.Ala68Thr Uncertain significance Single submitter
- MGMT p.Ala75Thr Uncertain significance Single submitter
- MGMT p.Arg206Gln Uncertain significance Single submitter
- MGMT p.Arg96Lys Uncertain significance Single submitter
- MGMT p.Arg9Leu Uncertain significance Single submitter
- MGMT p.Glu25Gly Uncertain significance Single submitter
- MGMT p.Gly109Arg Uncertain significance Single submitter
- MGMT p.Gly205Asp Uncertain significance Single submitter
- MGMT p.Gly54Arg Uncertain significance Single submitter
- MGMT p.His86Arg Uncertain significance Single submitter
- MGMT p.Ile141Val Uncertain significance Single submitter
- MGMT p.Leu181Phe Uncertain significance Single submitter
- MGMT p.Leu181Ser Uncertain significance Single submitter
- MGMT p.Leu33Phe Uncertain significance Single submitter
- MGMT p.Pro144Leu Uncertain significance Single submitter
- MGMT p.Pro47Ser Uncertain significance Single submitter
- MGMT p.Pro80Ala Uncertain significance Single submitter
- MGMT p.Ser152Asn Uncertain significance Single submitter
- MGMT p.Ser159Tyr Uncertain significance Single submitter
- MGMT p.Ser199Pro Uncertain significance Single submitter
- MGMT p.Thr38Met Uncertain significance Single submitter
- MGMT p.Thr95Ser Uncertain significance Single submitter
- MGMT p.Trp167Ser Uncertain significance Single submitter
- MGMT p.Val81Met Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All MGMT variants
Benign 1
- p.Lys178Arg Multiple submitters
Likely benign 6
- p.Glu30Lys Multiple submitters
- c.-64C>T Single submitter
- p.Ala190Thr Single submitter
- p.Ala41Thr Single submitter
- p.Ala51= Single submitter
- p.Pro87= Single submitter
Uncertain significance 36
- c.-54C>G Single submitter
- c.-60G>T Single submitter
- p.Ala126Gly Single submitter ⚠
- p.Ala197Thr Single submitter ⚠
- p.Ala68Thr Single submitter ⚠
- p.Ala75Thr Single submitter ⚠
- p.Arg206Gln Single submitter ⚠
- p.Arg9= Single submitter
- p.Arg96Lys Single submitter ⚠
- p.Arg9Leu Single submitter ⚠
- p.Glu25Gly Single submitter ⚠
- p.Gly109Arg Single submitter ⚠
- p.Gly153Arg Single submitter
- p.Gly205Asp Single submitter ⚠
- p.Gly54Arg Single submitter ⚠
- p.His174Tyr Single submitter ⚠
- p.His86Arg Single submitter ⚠
- p.Ile141Val Single submitter ⚠
- p.Leu181Phe Single submitter ⚠
- p.Leu181Ser Single submitter ⚠
- p.Leu33Phe Single submitter ⚠
- p.Phe94Tyr Single submitter ⚠
- p.Pro144Leu Single submitter ⚠
- p.Pro47Ser Single submitter ⚠
- p.Pro56Leu Single submitter ⚠
- p.Pro80Ala Single submitter ⚠
- p.Pro82Leu Single submitter ⚠
- p.Ser152Asn Single submitter ⚠
- p.Ser159Tyr Single submitter ⚠
- p.Ser199Pro Single submitter ⚠
- p.Thr38Met Single submitter ⚠
- p.Thr95Ser Single submitter ⚠
- p.Trp100Arg Single submitter ⚠
- p.Trp167Ser Single submitter ⚠
- p.Val149Phe Single submitter
- p.Val81Met Single submitter ⚠