Sugi Variant

Sugi Variant/MGP

MGP — 118 ClinVar variants

All ClinVar germline MGP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 33 flagged for review →

3 Pathogenic · 1 Pathogenic/Likely pathogenic · 1 Likely pathogenic · 5 Conflicting · 11 Benign · 5 Benign/Likely benign · 49 Likely benign · 43 Uncertain significance

Full MGP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 33

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 22

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 10

The independent predictors disagree with each other — read with care.

All MGP variants

Pathogenic 3

Pathogenic/Likely pathogenic 1

  • c.94+1G>A Multiple submitters Keutel syndrome

Likely pathogenic 1

Conflicting classifications of pathogenicity 5

Benign 11

Benign/Likely benign 5

Likely benign 49

Uncertain significance 43