MIDEAS — 173 ClinVar variants

All ClinVar germline MIDEAS variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 162 flagged for review →

8 Likely benign · 165 Uncertain significance

Full MIDEAS gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 162

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 137

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 25

The independent predictors disagree with each other — read with care.

All MIDEAS variants

Likely benign 8

p.Ala334Val Single submitter
p.Ala541Val Single submitter
p.Gly20Asp Single submitter
p.Ile354Val Single submitter
p.Pro278Gln Single submitter
p.Pro357Ser Single submitter
p.Ser925Gly Single submitter
p.Val153Met Single submitter

Uncertain significance 165

c.2162+1G>A Single submitter
p.Ala1001Val Single submitter ⚠
p.Ala170Val Single submitter ⚠
p.Ala203Thr Single submitter ⚠
p.Ala324Asp Single submitter ⚠
p.Ala55Glu Single submitter ⚠
p.Ala55Thr Single submitter ⚠
p.Ala620Thr Single submitter ⚠
p.Ala836Asp Single submitter ⚠
p.Ala836Thr Single submitter ⚠
p.Ala966Val Single submitter ⚠
p.Ala970Val Single submitter ⚠
p.Arg1013Gly Single submitter ⚠
p.Arg106Gln Single submitter ⚠
p.Arg13Trp Single submitter ⚠
p.Arg15Cys Single submitter ⚠
p.Arg167Trp Single submitter ⚠
p.Arg180Gln Single submitter ⚠
p.Arg227Gln Single submitter ⚠
p.Arg322Cys Single submitter ⚠
p.Arg344Cys Single submitter ⚠
p.Arg345Cys Single submitter ⚠
p.Arg345His Single submitter ⚠
p.Arg405Met Single submitter ⚠
p.Arg421Gln Single submitter ⚠
p.Arg423Gln Single submitter ⚠
p.Arg447Trp Single submitter ⚠
p.Arg456Gln Single submitter ⚠
p.Arg456Trp Single submitter ⚠
p.Arg459Gln Single submitter ⚠
p.Arg459Trp Single submitter ⚠
p.Arg492Gln Single submitter ⚠
p.Arg534Gln Single submitter ⚠
p.Arg569Leu Single submitter ⚠
p.Arg574Ter Single submitter
p.Arg598Gln Single submitter ⚠
p.Arg635His Single submitter ⚠
p.Arg693His Single submitter ⚠
p.Arg739Cys Single submitter ⚠
p.Arg739His Single submitter ⚠
p.Arg816Gln Single submitter ⚠
p.Arg82Gln Single submitter ⚠
p.Arg82Trp Single submitter ⚠
p.Arg959Gln Single submitter ⚠
p.Arg961His Single submitter ⚠
p.Arg961Leu Single submitter ⚠
p.Arg964Gln Single submitter ⚠
p.Asn419Ser Single submitter ⚠
p.Asn672Ser Single submitter ⚠
p.Asn807Ser Single submitter ⚠
p.Asn977Ser Single submitter ⚠
p.Asp287Asn Single submitter ⚠
p.Asp519Glu Single submitter ⚠
p.Asp738Asn Single submitter ⚠
p.Asp745Glu Single submitter ⚠
p.Gln122His Single submitter ⚠
p.Gln174His Single submitter ⚠
p.Gln218Glu Single submitter ⚠
p.Gln255Arg Single submitter ⚠
p.Gln36Lys Single submitter ⚠
p.Gln37Arg Single submitter ⚠
p.Gln462Pro Single submitter ⚠
p.Gln556Glu Single submitter ⚠
p.Gln581Arg Single submitter ⚠
p.Gln766His Single submitter ⚠
p.Gln832Arg Single submitter ⚠
p.Gln955Arg Single submitter ⚠
p.Glu1003Gln Single submitter ⚠
p.Glu1007Lys Single submitter ⚠
p.Glu352Asp Single submitter ⚠
p.Glu540Ala Single submitter ⚠
p.Glu555Lys Single submitter ⚠
p.Glu702Ala Single submitter ⚠
p.Glu720Lys Single submitter ⚠
p.Glu760Lys Single submitter ⚠
p.Glu81Lys Single submitter ⚠
p.Glu896Gly Single submitter ⚠
p.Glu944Val Single submitter ⚠
p.Gly111Val Single submitter ⚠
p.Gly113Ser Single submitter ⚠
p.Gly373Asp Single submitter ⚠
p.Gly433Cys Single submitter ⚠
p.Gly448Asp Single submitter ⚠
p.Gly546Arg Single submitter ⚠
p.Gly551Arg Single submitter ⚠
p.Gly577Arg Single submitter ⚠
p.Gly79Ala Single submitter ⚠
p.Gly958Arg Single submitter ⚠
p.His303Tyr Single submitter ⚠
p.His304Arg Single submitter ⚠
p.His989Gln Single submitter ⚠
p.Ile566Val Single submitter ⚠
p.Leu321Pro Single submitter ⚠
p.Leu349Phe Single submitter ⚠
p.Leu402Val Single submitter ⚠
p.Leu446Pro Single submitter ⚠
p.Leu759Pro Single submitter
p.Lys1022Asn Single submitter ⚠
p.Lys1023Glu Single submitter ⚠
p.Lys12Arg Single submitter ⚠
p.Lys146Glu Single submitter ⚠
p.Lys843Gln Single submitter ⚠
p.Lys952Glu Single submitter ⚠
p.Met182Thr Single submitter ⚠
p.Met183Leu Single submitter ⚠
p.Met306Leu Single submitter ⚠
p.Met317Thr Single submitter ⚠
p.Met317Val Single submitter ⚠
p.Met835Thr Single submitter ⚠
p.Phe1018Ser Single submitter ⚠
p.Phe288Cys Single submitter ⚠
p.Pro1017Arg Single submitter ⚠
p.Pro108Leu Single submitter ⚠
p.Pro149Leu Single submitter ⚠
p.Pro156Leu Single submitter ⚠
p.Pro162Thr Single submitter ⚠
p.Pro234Ala Single submitter ⚠
p.Pro235Leu Single submitter ⚠
p.Pro239Leu Single submitter ⚠
p.Pro245Ser Single submitter ⚠
p.Pro308Thr Single submitter ⚠
p.Pro313Arg Single submitter ⚠
p.Pro313Thr Single submitter ⚠
p.Pro34His Single submitter ⚠
p.Pro401Leu Single submitter ⚠
p.Pro418Leu Single submitter ⚠
p.Pro418Ser Single submitter ⚠
p.Pro426Ser Single submitter ⚠
p.Pro52Ser Single submitter ⚠
p.Pro621Ser Single submitter ⚠
p.Pro622Leu Single submitter ⚠
p.Pro629Ala Single submitter ⚠
p.Pro66Ala Single submitter ⚠
p.Pro716Ala Single submitter ⚠
p.Pro755Ser Single submitter ⚠
p.Pro821Leu Single submitter ⚠
p.Pro994Ser Single submitter ⚠
p.Pro994Thr Single submitter ⚠
p.Ser282Leu Single submitter ⚠
p.Ser299Phe Single submitter ⚠
p.Ser761Gly Single submitter ⚠
p.Ser925Cys Single submitter ⚠
p.Ser979Leu Single submitter ⚠
p.Thr454Met Single submitter ⚠
p.Thr468Asn Single submitter ⚠
p.Thr513Ser Single submitter ⚠
p.Thr539Ile Single submitter ⚠
p.Thr677Asn Single submitter ⚠
p.Thr687Ala Single submitter ⚠
p.Thr694Met Single submitter ⚠
p.Thr774Ile Single submitter ⚠
p.Thr893Met Single submitter ⚠
p.Tyr178Cys Single submitter ⚠
p.Val116Ala Single submitter ⚠
p.Val155Ala Single submitter ⚠
p.Val229Ala Single submitter ⚠
p.Val495Leu Single submitter ⚠
p.Val536Met Single submitter ⚠
p.Val597Met Single submitter ⚠
p.Val638Met Single submitter ⚠
p.Val717Leu Single submitter ⚠
p.Val725Leu Single submitter ⚠
p.Val752Met Single submitter ⚠
p.Val878Met Single submitter ⚠
p.Val95Ile Single submitter ⚠