MIF — 27 ClinVar variants
All ClinVar germline MIF variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 17 flagged for review →
2 Benign · 1 Benign/Likely benign · 4 Likely benign · 20 Uncertain significance
Full MIF gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 17
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MIF p.Ala58Thr Uncertain significance Multiple submitters
- MIF p.Ala71Pro Uncertain significance Single submitter
- MIF p.Arg74Gly Uncertain significance Single submitter
- MIF p.Arg74Leu Uncertain significance Single submitter
- MIF p.Asn111Thr Uncertain significance Single submitter
- MIF p.Gly69Asp Uncertain significance Single submitter
- MIF p.Leu84Arg Uncertain significance Single submitter
- MIF p.Met48Leu Uncertain significance Single submitter
- MIF p.Pro2Arg Uncertain significance Single submitter
- MIF p.Pro35His Uncertain significance Single submitter
- MIF p.Ser64Thr Uncertain significance Single submitter
- MIF p.Ser91Thr Uncertain significance Single submitter
- MIF p.Val107Glu Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All MIF variants
Benign 2
- c.282-9C>T Multiple submitters
- c.282-6C>G No assertion criteria MIF-related disorder
Benign/Likely benign 1
- c.282-7C>A Multiple submitters
Likely benign 4
- c.-24G>A Single submitter
- p.Glu86= Single submitter
- p.Ile68= No assertion criteria MIF-related disorder
- p.Ser75Phe No assertion criteria MIF-related disorder
Uncertain significance 20
- p.Ala58Thr Multiple submitters ⚠
- p.Ala28Thr Single submitter
- p.Ala28Val Single submitter
- p.Ala71Pro Single submitter ⚠
- p.Arg74Gly Single submitter ⚠
- p.Arg74Leu Single submitter ⚠
- p.Asn111Thr Single submitter ⚠
- p.Gly52Cys Single submitter
- p.Gly69Asp Single submitter ⚠
- p.Ile65Met Single submitter ⚠
- p.Leu84Arg Single submitter ⚠
- p.Met48Leu Single submitter ⚠
- p.Met48Val Single submitter ⚠
- p.Pro2Arg Single submitter ⚠
- p.Pro34Thr Single submitter ⚠
- p.Pro35His Single submitter ⚠
- p.Pro92Gln Single submitter ⚠
- p.Ser64Thr Single submitter ⚠
- p.Ser91Thr Single submitter ⚠
- p.Val107Glu Single submitter ⚠