MINK1 — 177 ClinVar variants

All ClinVar germline MINK1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 157 flagged for review →

2 Benign · 1 Benign/Likely benign · 11 Likely benign · 163 Uncertain significance

Full MINK1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 157

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 127

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 30

The independent predictors disagree with each other — read with care.

All MINK1 variants

Benign 2

p.Asp911= Single submitter
p.Leu1177= Single submitter

Benign/Likely benign 1

p.Ile705Leu Multiple submitters

Likely benign 11

p.Ala625Thr Single submitter
p.Asp836Glu Single submitter
p.Glu62= Single submitter
p.Ile675= Single submitter
p.Leu1284= Single submitter
p.Pro559Ala Single submitter
p.Pro650= Single submitter
p.Pro879Thr Single submitter
p.Ser326= Single submitter
p.Tyr1124= Single submitter
p.Leu1023Phe No assertion criteria EBV-positive nodal T- and NK-cell lymphoma

Uncertain significance 163

c.2199-2A>G Single submitter
c.2401-149G>A Single submitter
p.Ala445Val Single submitter ⚠
p.Ala632Thr Single submitter ⚠
p.Ala676Asp Single submitter ⚠
p.Ala676Thr Single submitter ⚠
p.Ala731Ser Single submitter ⚠
p.Ala731Thr Single submitter ⚠
p.Ala787Thr Single submitter ⚠
p.Arg1003Gln Single submitter
p.Arg1003Trp Single submitter ⚠
p.Arg1057Gln Single submitter
p.Arg1057Trp Single submitter ⚠
p.Arg1083Gln Single submitter ⚠
p.Arg1091Leu Single submitter ⚠
p.Arg1120His Single submitter ⚠
p.Arg1126Gln Single submitter ⚠
p.Arg1176Gln Single submitter ⚠
p.Arg1176Trp Single submitter ⚠
p.Arg1242His Single submitter ⚠
p.Arg1312Cys Single submitter ⚠
p.Arg1326Gly Single submitter ⚠
p.Arg1326His Single submitter ⚠
p.Arg290Trp Single submitter ⚠
p.Arg353Gln Single submitter ⚠
p.Arg396Gln Single submitter ⚠
p.Arg396Trp Single submitter ⚠
p.Arg397His Single submitter ⚠
p.Arg406Cys Single submitter ⚠
p.Arg437Trp Single submitter ⚠
p.Arg43Gln Single submitter ⚠
p.Arg442Gln Single submitter ⚠
p.Arg447Cys Single submitter ⚠
p.Arg509Trp Single submitter ⚠
p.Arg586Gln Single submitter ⚠
p.Arg608Gln Single submitter ⚠
p.Arg638His Single submitter ⚠
p.Arg659Cys Single submitter ⚠
p.Arg694Cys Single submitter ⚠
p.Arg694His Single submitter ⚠
p.Arg698His Single submitter ⚠
p.Arg710Gln Single submitter ⚠
p.Arg746His Single submitter ⚠
p.Arg766Gln Single submitter ⚠
p.Arg768Cys Single submitter ⚠
p.Arg768Leu Single submitter ⚠
p.Arg793Cys Single submitter ⚠
p.Arg798Trp Single submitter ⚠
p.Arg808Gln Single submitter ⚠
p.Arg80Cys Single submitter ⚠
p.Arg815Trp Single submitter ⚠
p.Arg981Gln Single submitter ⚠
p.Asn1331Ile Single submitter ⚠
p.Asn530Lys Single submitter ⚠
p.Asp1159Glu Single submitter ⚠
p.Asp1222Asn Single submitter ⚠
p.Asp1222His Single submitter ⚠
p.Asp171Glu Single submitter ⚠
p.Asp207Asn Single submitter ⚠
p.Asp748Gly Single submitter ⚠
p.Asp790Asn Single submitter ⚠
p.Asp791Asn Single submitter ⚠
p.Asp791Glu Single submitter ⚠
p.Asp861Asn Single submitter ⚠
p.Asp983Asn Single submitter ⚠
p.Asp988Asn Single submitter ⚠
p.Cys1262Ser Single submitter ⚠
p.Gln1175Leu Single submitter ⚠
p.Gln1207Arg Single submitter ⚠
p.Gln1250Pro Single submitter ⚠
p.Gln372Arg Single submitter ⚠
p.Gln377Leu Single submitter ⚠
p.Gln427Arg Single submitter ⚠
p.Gln459Arg Single submitter ⚠
p.Gln495Arg Single submitter ⚠
p.Gln878Arg Single submitter ⚠
p.Gln914His Single submitter ⚠
p.Glu1173Ala Single submitter ⚠
p.Glu1233Lys Single submitter ⚠
p.Glu315Gly Single submitter ⚠
p.Glu384Lys Single submitter ⚠
p.Glu403Gln Single submitter ⚠
p.Glu415Lys Single submitter ⚠
p.Glu441Gln Single submitter ⚠
p.Glu448Ala Single submitter ⚠
p.Glu525Asp Single submitter ⚠
p.Glu548Gln Single submitter ⚠
p.Glu576Asp Single submitter ⚠
p.Glu62Lys Single submitter ⚠
p.Glu663Lys Single submitter ⚠
p.Glu894Lys Single submitter ⚠
p.Gly1039Arg Single submitter ⚠
p.Gly1286Arg Single submitter ⚠
p.Gly325Ser Single submitter ⚠
p.Gly499Ala Single submitter ⚠
p.Gly683Glu Single submitter ⚠
p.Gly685Arg Single submitter ⚠
p.Gly843Arg Single submitter ⚠
p.Gly854Asp Single submitter ⚠
p.Gly876Arg Single submitter ⚠
p.Gly884Ser Single submitter ⚠
p.Gly958Arg Single submitter ⚠
p.His145Arg Single submitter ⚠
p.His755Gln Single submitter ⚠
p.His757Tyr Single submitter ⚠
p.Ile1055Thr Single submitter ⚠
p.Ile1075Val Single submitter ⚠
p.Ile1206Leu Single submitter ⚠
p.Ile53Val Single submitter ⚠
p.Ile637Thr Single submitter ⚠
p.Ile969Val Single submitter ⚠
p.Leu1069Arg Single submitter ⚠
p.Leu1166Val Single submitter ⚠
p.Leu233Met Single submitter ⚠
p.Leu496Pro Single submitter ⚠
p.Leu781Pro Single submitter ⚠
p.Leu957Ile Single submitter ⚠
p.Lys667Glu Single submitter ⚠
p.Lys717Arg Single submitter ⚠
p.Lys91Asn Single submitter ⚠
p.Lys944Asn Single submitter ⚠
p.Met1113Ile Single submitter ⚠
p.Met821Thr Single submitter ⚠
p.Pro383Arg Single submitter ⚠
p.Pro383Leu Single submitter ⚠
p.Pro536Ser Single submitter ⚠
p.Pro571Leu Single submitter
p.Pro578Leu Single submitter ⚠
p.Pro597Ser Single submitter ⚠
p.Pro621Arg Single submitter ⚠
p.Pro654Thr Single submitter ⚠
p.Pro655Thr Single submitter ⚠
p.Pro669Arg Single submitter ⚠
p.Pro718Leu Single submitter ⚠
p.Pro719Leu Single submitter ⚠
p.Pro742Arg Single submitter ⚠
p.Ser581Arg Single submitter ⚠
p.Ser651Gly Single submitter ⚠
p.Ser740Asn Single submitter ⚠
p.Ser740Gly Single submitter ⚠
p.Ser747Leu Single submitter ⚠
p.Ser794Leu Single submitter ⚠
p.Ser927Thr Single submitter ⚠
p.Ser930Leu Single submitter ⚠
p.Ser93Thr Single submitter ⚠
p.Thr1036Met Single submitter ⚠
p.Thr1239Ala Single submitter ⚠
p.Thr1281Met Single submitter ⚠
p.Thr294Met Single submitter
p.Thr627Ile Single submitter ⚠
p.Thr681Ile Single submitter ⚠
p.Thr715Ile Single submitter ⚠
p.Tyr960Phe Single submitter ⚠
p.Val1138Met Single submitter ⚠
p.Val28Ala Single submitter ⚠
p.Val408Met Single submitter ⚠
p.Val750Ile Single submitter ⚠
p.Val769Met Single submitter ⚠
p.Val830Leu Single submitter ⚠
p.Val871Ile Single submitter ⚠
p.Val871Leu Single submitter ⚠
p.Val975Met Single submitter ⚠
p.Val989Met Single submitter ⚠